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Lamb serum vitamin E and immunoglobulin G concentrations in response to various maternal mineral and iodine supplementation regimens

Published online by Cambridge University Press:  09 March 2007

T.M. Boland ,
J.J. Callan ,
P.O. Brophy ,
P.J. Quinn  and
T.F. Crosby
T.M. Boland
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
J.J. Callan
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
P.O. Brophy
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
P.J. Quinn
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
T.F. Crosby*
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
*
†Corresponding author. E-mail: [email protected]
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Abstract

The objective of the first of three studies (experiment 1) was to evaluate the effects of supplementing the pregnant ewe diet with high levels of minerals for the final 4 weeks of gestation on lamb serum vitamin E and immunoglobulin G (IgG) concentration at 24 h post partum. Sixty ewes were allocated to one of two treatments (no. =30) and offered a basal diet fortified with 52 g of supplementary minerals/vitamins containing Ca, Mg, Na, P, Co, I, Mn, Se, Zn and vitamin E (M1) for the final 4 weeks of pregnancy or no mineral/vitamin supplement was added (C1). Immediately after birth, lambs were allocated to one of four treatments in a 2×2 factorial design with the factors being ewe treatment (± minerals) and colostrum origin (± minerals). Irrespective of the colostrum origin, the progeny of the mineral supplemented ewes had lower serum vitamin E and IgG concentrations and IgG absorption efficiency at 24 h post partum ( P <0·001). In a second study (experiment 2), 44 ewes were allocated to one of four treatments (no. =11) in week 13 of pregnancy and offered a basal diet in addition to one of the following mineral/vitamin fortifications: 0 g (C2), 52 g of a mineral supplement as in experiment 1 (M2), a supplement as in M1 but with iodine excluded (-I), iodine only offered at a rate (40 mg per ewe per day) equivalent to 52 g of minerals (IO). When iodine was offered either M2 ( P <0·01) or (IO) ( P <0·001) it resulted in the progeny having a reduced serum vitamin E concentration at 24 h post partum. The -I progeny had higher serum vitamin E concentrations at 24 h post partum than the progeny of treatments C2, M2 ( P <0·01) and IO ( P <0·001). In a third study (experiment 3) the effect of incremental levels of iodine supplementation on lamb serum vitamin E concentration was studied. Forty-eight ewes were allocated to one of four treatments (no. =12) and offered the following levels of supplementary dietary iodine: 0 mg (C3), 8·9 mg (LI), 17·7 mg (MI) or 26·6 mg (HI) for the final 6 weeks of pregnancy. There was a linear ( P <0·001) reduction in lamb serum vitamin E concentration as maternal iodine supplementation increased. We conclude that when ewes are offered high levels of iodine during the final 6 weeks of gestation their progeny are pre-programmed in utero to have a reduced ability to absorb colostral vitamin E. These findings support our earlier studies and provide further evidence of the need to reduce the current toxicity values for iodine. for the ewe in late pregnancy.

Keywords

IgGiodinelambsmineral nutritionvitamin E
Type
Research Article
Information
Animal Science , Volume 82 , Issue 3 , June 2006 , pp. 319 - 325
Copyright
Copyright © British Society of Animal Science 2006

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References

Bieri, J. G., Tolliver, T. J. and Catignani, G. L. 1979. Simultaneous determination of α-tocopherol and retinal in plasma or red blood cells by high-pressure liquid chromatography. American Journal of Clinical Nutrition 32: 2143–2149.Google Scholar
Boland, T. M., Brophy, P. O., Callan, J. J., Quinn, P. J., Nowakowski, P. and Crosby, T. F. 2004a. The effects of mineral supplementation to ewes in late pregnancy on colostrum yield and immunoglobulin G absorption in their lambs. Proceedings of the British Society of Animal Science, 2004, p. 92 (abstr.).Google Scholar
Boland, T. M., Brophy, P. O., Callan, J. J., Quinn, P. J., Nowakowski, P. and Crosby, T. F. 2004b. The effects of mineral-block components when offered to ewes in late pregnancy on colostrum yield and immunoglobulin G absorption in their lambs. Animal Science 79: 293–302.CrossRefGoogle Scholar
Boland, T. M., Guinan, M., Brophy, P. O., Callan, J. J., Quinn, P. J., Nowakowski, P. and Crosby, T. F. 2005a. The effect of varying levels of mineral and iodine supplementation to ewes during late pregnancy on serum IgG concentrations in their progeny. Animal Science 80: 209–218.CrossRefGoogle Scholar
Boland, T. M., Keane, N., Nowakowski, P., Brophy, P. O. and Crosby, T. F. 2005b. High mineral and vitamin E intake by pregnant ewes lowers colostral immunoglobulin absorption by the lamb. Journal of Animal Science 83: 871–878.CrossRefGoogle ScholarPubMed
Brambell, F. W. R. 1970. The transmission of passive immunity from mother to young. In Frontiers of biology, vol. 18, pp. 166–200. North Holland Publishing Co., Amsterdam.Google Scholar
Coehlo, M. B. 1991. Functions of vitamin E. In Vitamin E in animal nutrition and management (ed. Coehlo, M. B.), pp. 11–17. BASF Corporation, New Jersey.Google Scholar
Crosby, T. F., Boland, T. M., Brophy, P. O., Quinn, P. J., Callan, J. J. and Joyce, D. 2004. The effects of offering mineral blocks to ewes pre-mating and in late pregnancy on block intake, pregnant ewe performance and immunoglobulin status of the progeny. Animal Science 79: 493–504.Google Scholar
Daniels, J. T., Hatfield, P. G., Burgess, D. E., Kott, R. W. and Bowman, J. G. P. 2000. Evaluation of ewe and lamb immune response when ewes were supplemented with vitamin E. Journal of Animal Science 78: 2731–2736.Google Scholar
Doney, J. M., Peart, J. N. and Smith, W. F. 1979. A consideration of the techniques for estimation of milk yield by suckled sheep and a comparison of estimates obtained by two methods in relation to the effect of breed, level of production and stage of lactation. Journal of Agricultural Science, Cambridge 92: 123–132.Google Scholar
Goodman, T., Bradley, L., Stockwell, C., Nickson, A. and Leach, R. A. 2004. A comparison of the effectiveness of three substitute colostrums fed to lambs. Proceedings of the British Society of Animal Science, p. 152 (abstr.).Google Scholar
Hatfield, P. G., Daniels, J. T., Kott, R. W., Burgess, B. E. and Evans, T. J. 1999. Role of supplemental vitamin E in lamb survival and production: a review. Proceedings of the American Society of Animal Science E25: 1–9.Google Scholar
Hidiroglou, M., Jenkins, K. J. and Lessard, J. R. 1970. Metabolism of vitamin E in sheep. British Journal of Nutrition 24: 917–928.Google Scholar
Jeffries, B. C. 1961. Body condition scoring and its use in management. Tasmanian Journal of Agriculture 32: 19–21.Google Scholar
Keane, N. Some factors influencing early lamb performance and IgG absorption in March born lambs. M.Agr.Sc, thesis, National University of Ireland.Google Scholar
Klobosa, F. and Werhahn, E. 1989. Variations in the concentrations of the immunoglobulins IgG1, IgG2 and IgA in sheep. 2. Changes in the blood of lambs of different breeds and crossbreeds during the course of the rearing period. Berliner und Münchener Tierärztliche Wochenschrift 102: 331–337 (abstr.).Google Scholar
Kott, R. W., Thomas, V. M., Hatfield, P. G., Evans, T. and Davis, K. C. 1998. The influence of vitamin E supplementation during late pregnancy on lamb mortality and ewe productivity. Journal of the American Veterinary Medical Association 212: 997–1000.CrossRefGoogle Scholar
Maher, P., 1995 The effect of forage type on ewe and lamb performance. M.Agr.Sc. thesis, National University of Ireland.Google Scholar
Mason, K. E. and Bryan, W. L. 1940. Placental and mammary transfer of vitamin E in the rat. Journal of Nutrition 20: 501.Google Scholar
National Research Council. 1985. Nutrient requirements of sheep, sixth edition. National Academy of Sciences, Washington, DC.Google Scholar
Njeru, C. A., McDowell, L. R., Wilkinson, N. S., Linda, S. B. and Williams, S. N. 1994. Pre and postpartum supplemental DL-α-tocopherol acetate effects on placental and mammary vitamin E transfer in sheep. Journal of Animal Science 72: 1636–1640.CrossRefGoogle ScholarPubMed
O'Doherty, J. V. and Crosby, T. F. 1997. The effect of diet in late pregnancy on colostrum production and immunoglobulin absorption in sheep. Animal Science 64: 87–96.Google Scholar
Ostrea, E. M., Balun, J. E., Winkler, R. and Porter, T. 1986. Influence of breast-feeding on the restoration of the low serum concentration of vitamin E and β-carotene in the newborn infant. American Journal of Obstetrics and Gynaecology 154: 1014–1017.CrossRefGoogle ScholarPubMed
Pehrson, B., Hakkarainen, J. and Blomgren, L. 1990. Vitamin E status in newborn lambs with special reference to the effect of DL-α-tocopherol acetate supplementation in late gestation. Acta Veterinaria Scandinavica 31: 359–367.CrossRefGoogle Scholar
Puls, R. 1994. Levels in animal health: diagnostic data and bibliographies, first edition. Sherpa International, Clearbrook, BC, Canada.Google Scholar
Statistical Analysis Systems Institute. 1985. Statistical analysis systems, version 6.12. SAS Institute Inc., Cary, NC.Google Scholar
Thomas, V. M., Roeder, B., Bohn, G., Kott, R. W. and Evans, T. 1995. Influence of late pregnancy feeding of vitamin E on lamb mortality and ewe productivity. Proceedings of the Western Section of the American Society of Animal Science 46: 91–94.Google Scholar