Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-28T04:36:31.106Z Has data issue: false hasContentIssue false
  • English
  • Français

Changes in the composition of plasma very low density lipoprotein during pregnancy and lactation in genetic lines of pigs

Published online by Cambridge University Press:  02 September 2010

M. M. Wright ,
I. J. Lean ,
E. Herrera  and
P. F. Dodds
M. M. Wright
Affiliation:
Department of Biological Sciences
I. J. Lean
Affiliation:
Department of Agriculture, Wye College, University of London, Wye, Ashford, Kent TN25 5AH
E. Herrera
Affiliation:
Departamento de Investigacíon, Centro Ramón y Cajal, 28034-Madrid, Spain
P. F. Dodds
Affiliation:
Department of Biological Sciences
Get access

Abstract

Plasma very low density lipoproteins (VLDL) of gilts were separated into two sub fractions according to their affinity for heparin. The proportion of VLDL present as subfraction 2 (higher affinity for heparin) varied, according to the genetic line of the pigs, between 0·21 and 0·78 in virgin gilts. The proportions were related to the variation in piglet survival in the same nine genetic lines by a quadratic equation, which predicted that greater than 90% survival to weaning was to be found in piglets born to gilts having between about 0·3 and 0·7 of their VLDL as subfraction 2. This observation suggests a simple measurement that could be used in the selection of sows for a breeding programme. The proportion of subfraction 2 fell throughout pregnancy in each of three genetic lines measured and only returned to pre-pregnant values after weaning: these changes did not correlate with the changes in the lipid composition of plasma VLDL measured during pregnancy and lactation. The findings suggest a role for the VLDL subfractions in controlling the nutrition of the neonatal pig.

Keywords

lactationlipoproteinsplasma lipidspregnancysows
Type
Research Article
Information
Animal Science , Volume 61 , Issue 2 , October 1995 , pp. 361 - 368
Copyright
Copyright © British Society of Animal Science 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boyd, R. D., Moser, B. D., Peo, E. R. and Cunningham, P. J. 1978. Effect of energy source prior to parturition and during lactation on tissue lipid, liver glycogen and plasma levels of some metabolites in the newborn pig. Journal of Animal Science 47: 874–882.CrossRefGoogle ScholarPubMed
Coleman, R. A. 1989. The role of the placenta in lipid-metabolism and transport. Seminars in Perinatology 13: 180–191.Google ScholarPubMed
Davis, R. A. 1991. Lipoprotein structure and function. In Biochemistry of lipids, lipoproteins and membranes (ed. Vance, D. E. and Vance, J.), pp. 403–426. Elsevier, Amsterdam.Google Scholar
English, P. R. and Morrison, V. 1984. Causes and prevention of piglet mortality. Pig News and Information 5: 369–376.Google Scholar
English, P. R. and Wilkinson, V. 1982. Management of the sow and litter in late pregnancy and lactation in relation to piglet survival and growth. In Control of pig reproduction (ed. Cole, D. J. A. and Foxcroft, G. R.), pp. 479–506. Butterworth Scientific, London.CrossRefGoogle Scholar
Evans, A. J., Huff, M. W. and Wolfe, B. M. 1989. Accumulation of an apoE-poor subfraction of very low density lipoprotein in hypertriglyceridemic men. journal of lipid Research 30: 1691–1701.CrossRefGoogle ScholarPubMed
Fielding, P. E. and Fielding, C. J. 1991. Dynamics of lipoprotein transport in the circulatory system. In Biochemistry of lipids, lipoproteins and membranes (ed. Vance, D. E. and Vance, J.), pp. 427–459. Elsevier Science, Amsterdam.Google Scholar
Fielding, P. E., Ishikawa, Y. and Fielding, C. J. 1989. Apolipoprotein E mediates binding of normal very low density lipoprotein to heparin but is not required for high affinity receptor binding. Journal of Biological Chemistry 264: 12462–12466.CrossRefGoogle Scholar
Gòmez-Coronado, D., Sàez, G. T., Lasuncion, M. A. and Herrera, E. 1993. Different hydrolytic efficiencies of adipose tissuelipoprotein lipase on very-low-density-lipoprotein subfractions separated heparin-Sepharosechromatography. Biochimica et Biophyska Ada 1167: 70–78.CrossRefGoogle Scholar
Gurr, M. I. 1988. Comparative aspects of nutrient metabolism: lipid metabolism. In Comparative nutrition (ed. Blaxter, K. and MacDonald, I.), pp. 73–90. John Libby, London.Google Scholar
Herrera, E., Gomez-Coronado, D. and Lasuncion, M. A. 1987. Lipid metabolism in pregnancy. Biology of the Neonate 51: 70–77.CrossRefGoogle ScholarPubMed
Herrera, E., Lasuncion, M. A., Martin, A. and Zorzano, A. 1992. Carbohydrate-lipid interactions in pregnancy. In Perinatal biochemistry (ed. Herrera, E. and Knopp, R. H.), pp. 1–18. CRC Press, Boca Raton.Google Scholar
Huff, M. W. and Telford, D. E. 1984. Characterization and metabolic fate of two very-low-density-lipoprotein subfractions separated by heparin-Sepharose chromatography. Biochimica et Biophyska Ada 796: 251–261.CrossRefGoogle ScholarPubMed
Knopp, R. H., Warth, M. R., Charles, D., Childs, M., Li, J. R., Mabuchi, H. and Van Allen, M. I. 1986. Lipoprotein metabolism in pregnancy, fat transport to the fetus, and the effects of diabetes. Biology of the Neonate 50: 297–317.CrossRefGoogle Scholar
Montelongo, A., Lasuncion, M. A., Pallardo, L. F. and Herrera, E. 1992. Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes 41: 1651–1659.CrossRefGoogle ScholarPubMed
Moser, B. D. 1983. The use of fat in sow diets. In Recent advances in animal nutrition – 1983 (ed. Haresign, W.), pp. 71–80. Butterworths, London.Google Scholar
Muirhead, M. R. 1981. Blood sampling in pigs. In Practice 3: (5), 16–20.CrossRefGoogle ScholarPubMed
Pettigrew, J. E. 1981. Supplemental dietary fat for peripartal sows: a review. Journal of Animal Science 93: 107–117.CrossRefGoogle Scholar
Ramirez, I., Llobera, M. and Herrera, E. 1983. Circulating triacylglycerols, lipoproteins, and tissue lipoprotein lipase activities in rat mothers and offspring during the perinatal period: effect of postmaturity. Metabolism 32: 333–341.CrossRefGoogle ScholarPubMed
Reese, D. E., Peo, E. R., Lewis, A. J. and Hogg, A. 1984. Serum chemical values of gestating and lactating swine: reference values. American Journal of Veterinary Research 45: 978–980.Google ScholarPubMed
Ribadeau-Dumas, B. 1983. Le lait maternal. La Recherche 14: 8–18.Google Scholar
Shelburne, F. A. and Quarfordt, S. H. 1977. The interaction of heparin with an apoprotein of human very low density lipoprotein. Journal of Clinical Investigation 60: 944–950.CrossRefGoogle ScholarPubMed
Trezzi, E., Calvi, C., Roma, P. and Catapano, A. L. 1983. Subfractionation of human very low density lipoproteins by heparin-Sepharose affinity chromatography. journal of Lipid Research 24: 790–795.CrossRefGoogle ScholarPubMed
Webb, A. J. and Curran, M. K. 1986. Selection regime by production system interaction in pig improvement: a review of possible causes and solutions. Livestock Production Science 14: 41–54.CrossRefGoogle Scholar