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Vaccination of calves against common respiratory viruses in the face of maternally derived antibodies(IFOMA)

Published online by Cambridge University Press:  04 April 2016

Manuel F. Chamorro ,
Amelia Woolums  and
Paul H. Walz
Manuel F. Chamorro*
Affiliation:
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan KS 66506, USA
Amelia Woolums
Affiliation:
Deparments of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Starkville, MS 39759, USA
Paul H. Walz
Affiliation:
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn AL 36849, USA
*
*Corresponding author. E-mail: [email protected]
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Abstract

Vaccination of calves in the face of maternal antibodies (IFOMA) often does not result in seroconversion as maternally derived immunity interferes with the activation of adequate antibody responses to vaccination; however, it can prime T and B cell memory responses that protect calves against clinical disease when maternal immunity has decayed. The activation of B and T cell memory responses in calves vaccinated IFOMA varies and is affected by several factors, including age, level of maternal immunity, type of vaccine, and route of administration. These factors influence the adequate priming of humoral and cell mediated immune responses and the outcome of vaccination. The failure to adequately prime immune memory after vaccination IFOMA could result in lack of clinical protection and increased risk of viremia and/or virus shedding.

Keywords

colostrummaternalantibodyvaccinationBVDVBRSV
Type
Review Article
Information
Animal Health Research Reviews , Volume 17 , Issue 2 , December 2016 , pp. 79 - 84
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Copyright
Copyright © Cambridge University Press 2016 

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