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A systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update

Published online by Cambridge University Press:  18 July 2016

J. N. Cullen ,
C. Yuan ,
S. Totton ,
R. Dzikamunhenga ,
J. F. Coetzee ,
N. da Silva ,
C. Wang  and
A. M. O'Connor
J. N. Cullen
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 500010, USA
C. Yuan
Affiliation:
Department of Statistics, College of Agriculture and Life Sciences, Iowa State University, Ames, Iowa, USA
R. Dzikamunhenga
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 500010, USA
J. F. Coetzee
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 500010, USA
N. da Silva
Affiliation:
Department of Statistics, College of Agriculture and Life Sciences, Iowa State University, Ames, Iowa, USA
C. Wang
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 500010, USA Department of Statistics, College of Agriculture and Life Sciences, Iowa State University, Ames, Iowa, USA
A. M. O'Connor*
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 500010, USA
*
*Corresponding author. E-mail: [email protected]
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Abstract

Infectious bovine keratoconjunctivitis (IBK) is a common and important disease of calves. Without effective vaccines, antibiotic therapy is often implemented to minimize the impact of IBK. This review updates a previously published systematic review regarding comparative efficacy for antibiotic treatments of IBK. Available years of Centre for Biosciences and Agriculture International and MEDLINE databases were searched, including non-English results. Also searched were the American Association of Bovine Practitioners and World Buiatrics Congress conference proceedings from 1996 to 2016, reviews since 2013, reference lists from relevant trials, and U.S. Food and Drug Administration New Animal Drug Application summaries. Eligible studies assessed antibiotic treatment of naturally-occurring IBK in calves randomly allocated to group at the individual level. Outcomes of interest were clinical score, healing time, unhealed ulcer risk, and ulcer surface area. A mixed-effects model comparing active drug with placebo was employed for all outcomes. Heterogeneity was assessed visually and using Cochran's Q-test. Thirteen trials assessing nine treatments were included. Compared with placebo, most antibiotic treatments were effective. There was evidence that the treatment effect differed by day of outcome measurement. Visually, the largest differences were observed 7–14 days post-treatment. These results indicate improved IBK healing with many antibiotics and suggest the need for randomized trials comparing different antibiotic treatments.

Keywords

antibioticsinfectious bovine keratoconjunctivitismeta-analysispinkeyesystematic review
Type
Review Article
Information
Animal Health Research Reviews , Volume 17 , Special Issue 1: Systematic Reviews , June 2016 , pp. 60 - 75
Copyright
Copyright © Cambridge University Press 2016 

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