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The molecular biology of bovine immunodeficiency virus: a comparison with other lentiviruses

Published online by Cambridge University Press:  28 February 2007

Marie-Claude St-Louis ,
Mihaela Cojocariu  and
Denis Archambault
Marie-Claude St-Louis
Affiliation:
University of Québec at Montréal, Department of Biological Sciences, Montréal, Québec, Canada
Mihaela Cojocariu
Affiliation:
University of Québec at Montréal, Department of Biological Sciences, Montréal, Québec, Canada
Denis Archambault*
Affiliation:
University of Québec at Montréal, Department of Biological Sciences, Montréal, Québec, Canada
*
*University of Québec at Montréal, Department of Biological Sciences, P.O. Box 8888, Succursale Centre-Ville, Montréal, Québec, CanadaH3C 3P8 E-mail: [email protected]
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Abstract

Bovine immunodeficiency virus (BIV) was first isolated in 1969 from a cow, R-29, with a wasting syndrome. The virus isolated induced the formation of syncytia in cell cultures and was structurally similar to maedi-visna virus. Twenty years later, it was demonstrated that the bovine R-29 isolate was indeed a lentivirus with striking similarity to the human immunodeficiency virus. Like other lentiviruses, BIV has a complex genomic structure characterized by the presence of several regulatory/accessory genes that encode proteins, some of which are involved in the regulation of virus gene expression. This manuscript aims to review biological and, more particularly, molecular aspects of BIV, with emphasis on regulatory/accessory viral genes/proteins, in comparison with those of other lentiviruses.

Keywords

molecular biologybovine immunodeficiency viruslentiviruses
Type
Research Article
Information
Animal Health Research Reviews , Volume 5 , Issue 2 , December 2004 , pp. 125 - 143
Copyright
Copyright © CAB International 2004

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