Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-08T09:26:06.523Z Has data issue: false hasContentIssue false
  • English
  • Français

A literature review of antimicrobial resistance in Pathogens associated with bovine respiratory disease

Published online by Cambridge University Press:  16 September 2015

K.D. DeDonder  and
M.D. Apley
K.D. DeDonder*
Affiliation:
Diagnostic Medicine/Pathobiology, Kansas State University College of Veterinary Medicine, KS 66506, USA
M.D. Apley
Affiliation:
Clinical Sciences, Kansas State University College of Veterinary Medicine, KS 66506, USA
*
* Corresponding Author. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The objective of this paper was to perform a critical review of the literature as it pertains to the current status of antimicrobial resistance in pathogens associated with bovine respiratory disease (BRD) in beef cattle and to provide a concise yet informative narrative on the most relevant publications available. As such, the scientific literature contained in PubMed, AGRICOLA, and CAB were searched in February of 2014 for articles related to susceptibility testing of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni from cases of BRD. Titles and abstracts were read and 105 articles that were relevant to the subject of BRD antibiotic resistance were attained for further review. After the application of exclusion criterion (publications must have originated from North America, be in English, adhere to standards set forth by the Clinical and Laboratory Standards Institute, and be concerning antimicrobial resistance in BRD in beef cattle), 16 articles remained and are the focus of this publication. Due to the disparate data from the few studies that investigate susceptibility testing of BRD pathogens, a quantitative assessment or meta-analysis was not performed on the studies presented in this review. However, considering diagnostic lab data, there appears to be a clear trend of a decrease in susceptibility of the three major BRD pathogens to the antimicrobials used commonly for treatment and control of BRD. Studies performing sensitivity testing on healthy cattle report much lower resistance, but it remains unclear if this is because of a true lack of resistance mechanisms, or if the isolates do contain quiescent genes for resistance that are only phenotypically expressed following the administration of an antimicrobial for either treatment or control of BRD. Future research to address this question of genotype and phenotypic expression before and after antimicrobial administration will further advance our knowledge in this area.

Keywords

Bovine respiratory diseaseantimicrobial resistanceantibiotic resistancesusceptibility testingMannheimia haemolyticaPasteurella multocidaHistophilus somni
Type
Review Article
Information
Animal Health Research Reviews , Volume 16 , Issue 2 , December 2015 , pp. 125 - 134
Check for updates
Copyright
Copyright © Cambridge University Press 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alexander, TW, Cook, S, Klima, CL, Topp, E and Mcallister, TA (2013a). Susceptibility to tulathromycin in Mannheimia haemolytica isolated from feedlot cattle over a 3-year period. Frontiers in Microbiology 4: 297.CrossRefGoogle ScholarPubMed
Alexander, TW, Jin, X, Li, Q, Cook, S and Mcallister, TA (2013b). Characterization of tetracycline resistance genes in Escherichia coli isolated from feedlot cattle administered therapeutic or subtherapeutic levels of tetracycline. Canadian Journal of Microbiology 59: 287–290.CrossRefGoogle ScholarPubMed
Apley, MD (2003). Susceptibility testing for bovine respiratory and enteric disease. Veterinary Clinics of the North America: Food Animal Practice 19: 625–46.Google ScholarPubMed
Chang, WH and Carter, GR (1976). Multiple drug resistance in Pasteurella multocida and Pasteurella haemolytica from cattle and swine. Journal of the American Veterinary Medical Association 169: 710–712.Google ScholarPubMed
Clinical and Laboratory Standards Institute and VET02-A3 (February 2008). Development of In Vitro Susceptibility testing Criteria and Quality Control Parameters for Veterinary Antimicrobial Agents; Approved Guideline – Third Edition (Formerly M37-A3).Google Scholar
Clinical and Laboratory Standards Institute VET01-A4 (July 2013). Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria isolated from Animals; Approved Standard - Fourth Edition (Formerly M31-A4).Google Scholar
Clinical and Laboratory Standards Institute VET01-S2 (July 2013). Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria isolated from Animals; Second Informational Supplement.Google Scholar
D'Amours, GH, Ward, TI, Mulvey, MR, Read, RR and Morck, DW (2011). Genetic diversity and tetracycline resistance genes of Histophilus somni . Veterinary Microbiology 150: 362–372.CrossRefGoogle ScholarPubMed
Desmolaize, B, Rose, S, Warrass, R and Douthwaite, S (2011a). A novel Erm monomethyltransferase in antibiotic-resistant isolates of Mannheimia haemolytica and Pasteurella multocida . Molecular Microbiology 80: 184–194.CrossRefGoogle ScholarPubMed
Desmolaize, B, Rose, S, Wilhelm, C, Warrass, R and Douthwaite, S (2011b). Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida . Antimicrobial Agents and Chemotherapy 55: 4128–4133.CrossRefGoogle ScholarPubMed
Glisan, GL, Steele, JH, Whitford, H, Christensen, BL and Kapadia, A (1982). Antimicrobic resistance and susceptibility in five bacterial pathogens: a comparison of susceptibility tests in 1974 and 1978. Journal of the American Veterinary Medical Association 180: 665–668.Google ScholarPubMed
Kadlec, K, Brenner Michael, G, Sweeney, MT, Brzuszkiewicz, E, Liesegang, H, Daniel, R, Watts, JL and Schwarz, S (2011). Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease. Antimicrobial Agents and Chemotherapy 55: 2475–2477.CrossRefGoogle ScholarPubMed
Kaspar, H (2006). Results of the antimicrobial agent susceptibility study raised in a representative, cross-sectional monitoring study on a national basis. International Journal of Medical Microbiology, 296 (suppl. 41): 69–79.CrossRefGoogle Scholar
Katsuda, K, Kohmoto, M, Mikami, O, Tamamura, Y and Uchida, I (2012). Plasmid-mediated florfenicol resistance in Mannheimia haemolytica isolated from cattle. Veterinary Microbiology 155: 444–447.CrossRefGoogle ScholarPubMed
Katsuda, K, Kohmoto, M and Mikami, O (2013). Relationship between serotype and the antimicrobial susceptibility of Mannheimia haemolytica isolates collected between 1991 and 2010. Research in Veterinary Science 94: 205–208.CrossRefGoogle ScholarPubMed
Kehrenberg, C, Catry, B, Haesebrouck, F, De Kruif, A and Schwarz, S (2005). tet(L)-mediated tetracycline resistance in bovine Mannheimia and Pasteurella isolates. Journal of Antimicrobial Chemotherapy 56: 403–406.CrossRefGoogle ScholarPubMed
Kehrenberg, C, Wallmann, J and Schwarz, S (2008). Molecular analysis of florfenicol-resistant Pasteurella multocida isolates in Germany. Journal of Antimicrobial Chemotherapy 62: 951–955.CrossRefGoogle ScholarPubMed
Klima, CL, Alexander, TW, Read, RR, Gow, SP, Booker, CW, Hannon, S, Sheedy, C, Mcallister, TA and Selinger, LB (2011). Genetic characterization and antimicrobial susceptibility of Mannheimia haemolytica isolated from the nasopharynx of feedlot cattle. Veterinary Microbiology 149: 390–398.CrossRefGoogle ScholarPubMed
Klima, CL, Alexander, TW, Hendrick, S and Mcallister, TA (2014a). Characterization of Mannheimia haemolytica isolated from feedlot cattle that were healthy or treated for bovine respiratory disease. Canadian Journal of Veterinary Research 78: 38–45.Google ScholarPubMed
Klima, CL, Zaheer, R, Cook, SR, Booker, CW, Hendrick, S, Alexander, TW and Mcallister, TA (2014b). Pathogens of bovine respiratory disease in North American feedlots conferring multidrug resistance via integrative conjugative elements. Journal of Clinical Microbiology 52: 438–448.CrossRefGoogle ScholarPubMed
Lamm, CG, Love, BC, Krehbiel, CR, Johnson, NJ and Step, DL (2012). Comparison of antemortem antimicrobial treatment regimens to antimicrobial susceptibility patterns of postmortem lung isolates from feedlot cattle with bronchopneumonia. Journal of Veterinary Diagnostic Investigation 24: 277–282.CrossRefGoogle ScholarPubMed
Lubbers, BV & Hanzlicek, GA (2013). Antimicrobial multidrug resistance and coresistance patterns of Mannheimia haemolytica isolated from bovine respiratory disease cases–a three-year (2009–2011) retrospective analysis. Journal of Veterinary Diagnostic Investigation 25: 413–417.CrossRefGoogle ScholarPubMed
Mcclary, DG, Loneragan, GH, Shryock, TR, Carter, BL, Guthrie, CA, Corbin, MJ and Mechor, GD (2011). Relationship of in vitro minimum inhibitory concentrations of tilmicosin against Mannheimia haemolytica and Pasteurella multocida and in vivo tilmicosin treatment outcome among calves with signs of bovine respiratory disease. Journal of the American Veterinary Medical Association 239: 129–135.CrossRefGoogle ScholarPubMed
Michael, GB, Eidam, C, Kadlec, K, Meyer, K, Sweeney, MT, Murray, RW, Watts, JL and Schwarz, S (2012a). Increased MICs of gamithromycin and tildipirosin in the presence of the genes erm(42) and msr(E)-mph(E) for bovine Pasteurella multocida and Mannheimia haemolytica . Journal of Antimicrobial Chemotherapy 67: 1555–1557.CrossRefGoogle Scholar
Michael, GB, Kadlec, K, Sweeney, MT, Brzuszkiewicz, E, Liesegang, H, Daniel, R, Murray, RW, Watts, JL and Schwarz, S (2012b). ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: analysis of the regions that comprise 12 antimicrobial resistance genes. Journal of Antimicrobial Chemotherapy 67: 84–90.CrossRefGoogle ScholarPubMed
Michael, GB, Kadlec, K, Sweeney, MT, Brzuszkiewicz, E, Liesegang, H, Daniel, R, Murray, RW, Watts, JL and Schwarz, S (2012c). ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: analysis of the regions that comprise 12 antimicrobial resistance genes. Journal of Antimicrobial Chemotherapy 67: 84–90.CrossRefGoogle ScholarPubMed
O'Connor, AM, Wellman, NG, Rice, M and Funk, L (2010). Characteristics of clinical trials assessing antimicrobial treatment of bovine respiratory disease, 1970–2005. Journal of the American Veterinary Medical Association 237: 701–705.CrossRefGoogle ScholarPubMed
Pardon, B, Hostens, M, Duchateau, L, Dewulf, J, De Bleecker, K and Deprez, P (2013). Impact of respiratory disease, diarrhea, otitis and arthritis on mortality and carcass traits in white veal calves. BMC Veterinary Research 9: 79.CrossRefGoogle ScholarPubMed
Portis, E, Lindeman, C, Johansen, L and Stoltman, G (2012). A ten-year (2000–2009) study of antimicrobial susceptibility of bacteria that cause bovine respiratory disease complex–Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni–in the United States and Canada. Journal of Veterinary Diagnostic Investigation 24: 932–944.CrossRefGoogle Scholar
Post, KW, Cole, NA and Raleigh, RH (1991). In vitro antimicrobial susceptibility of Pasteurella haemolytica and Pasteurella multocida recovered from cattle with bovine respiratory disease complex. Journal of Veterinary Diagnostic Investigation 3: 124–126.CrossRefGoogle ScholarPubMed
Shin, SJ, Kang, SG, Nabin, R, Kang, ML and Yoo, HS (2005). Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease. Veterinary Microbiology 106: 73–77.CrossRefGoogle ScholarPubMed
Singer, RS, Case, JT, Carpenter, TE, Walker, RL and Hirsh, DC (1998). Assessment of spatial and temporal clustering of ampicillin- and tetracycline-resistant strains of Pasteurella multocida and P. haemolytica isolated from cattle in California. Journal of the American Veterinary Medical Association 212: 1001–1005.CrossRefGoogle ScholarPubMed
Van Donkersgoed, J, Merrill, J and Hendrick, S (2008). Comparative efficacy of tilmicosin versus tulathromycin as a metaphylactic antimicrobial in feedlot calves at moderate risk for respiratory disease. Veterinary Therapeutics 9: 291–297.Google ScholarPubMed
Watanabe, T (1967). Infectious drug resistance. Scientific American 217: 19–28.CrossRefGoogle ScholarPubMed
Watts, JL and Sweeney, MT (2010). Antimicrobial resistance in bovine respiratory disease pathogens: measures, trends, and impact on efficacy. Veterinary Clinics of the North America: Food Animal Practice 26: 79–88, table of contents.Google ScholarPubMed
Watts, JL, Yancey, RJ Jr, Salmon, SA and Case, CA (1994). A 4-year survey of antimicrobial susceptibility trends for isolates from cattle with bovine respiratory disease in North America. Journal of Clinical Microbiology 32: 725–731.CrossRefGoogle ScholarPubMed
Welsh, RD, Dye, LB, Payton, ME and Confer, AW (2004). Isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994–2002. Journal of Veterinary Diagnostic Investigation 16: 426–431.CrossRefGoogle ScholarPubMed
Zaheer, R, Cook, SR, Klima, CL, Stanford, K, Alexander, T, Topp, E, Read, RR and Mcallister, TA (2013). Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle. Frontiers in Microbiology 4: 133.CrossRefGoogle ScholarPubMed