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Immune responses against Marek's disease virus

Published online by Cambridge University Press:  19 May 2010

Payvand Parvizi
Affiliation:
Department of Pathobiology, University of Guelph, Guelph N1G 2W1, Canada
Mohamed Faizal Abdul-Careem
Affiliation:
Department of Pathobiology, University of Guelph, Guelph N1G 2W1, Canada
Kamran Haq
Affiliation:
Department of Pathobiology, University of Guelph, Guelph N1G 2W1, Canada
Niroshan Thanthrige-Don
Affiliation:
Department of Pathobiology, University of Guelph, Guelph N1G 2W1, Canada
Karel A. Schat
Affiliation:
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY14853, USA
Shayan Sharif*
Affiliation:
Department of Pathobiology, University of Guelph, Guelph N1G 2W1, Canada
*
*Corresponding author. E-mail: [email protected]

Abstract

It is more than a century since Marek's disease (MD) was first reported in chickens and since then there have been concerted efforts to better understand this disease, its causative agent and various approaches for control of this disease. Recently, there have been several outbreaks of the disease in various regions, due to the evolving nature of MD virus (MDV), which necessitates the implementation of improved prophylactic approaches. It is therefore essential to better understand the interactions between chickens and the virus. The chicken immune system is directly involved in controlling the entry and the spread of the virus. It employs two distinct but interrelated mechanisms to tackle viral invasion. Innate defense mechanisms comprise secretion of soluble factors as well as cells such as macrophages and natural killer cells as the first line of defense. These innate responses provide the adaptive arm of the immune system including antibody- and cell-mediated immune responses to be tailored more specifically against MDV. In addition to the immune system, genetic and epigenetic mechanisms contribute to the outcome of MDV infection in chickens. This review discusses our current understanding of immune responses elicited against MDV and genetic factors that contribute to the nature of the response.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2010

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References

Abdul-Careem, MF, Hunter, BD, Sarson, AJ, Mayameei, A, Zhou, H and Sharif, S (2006). Marek's disease virus-induced transient paralysis is associated with cytokine gene expression in the nervous system. Viral Immunology 19: 167176.CrossRefGoogle ScholarPubMed
Abdul-Careem, MF, Haq, K, Shanmuganathan, S, Read, LR, Schat, KA, Heidari, M and Sharif, S (2009). Induction of innate host responses in the lungs of chickens following infection with a very virulent strain of Marek's disease virus. Virology 2: 250–7. Epub 2009 Sep 4.CrossRefGoogle Scholar
Abdul-Careem, MF, Hunter, BD, Parvizi, P, Haghighi, HR, Thanthrige-Don, N and Sharif, S (2007). Cytokine gene expression patterns associated with immunization against Marek's disease in chickens. Vaccine 25: 424432.Google Scholar
Abdul-Careem, MF, Hunter, BD, Lee, LF, Fairbrother, JH, Haghighi, HR, Read, L, Parvizi, P, Heidari, M and Sharif, S (2008a). Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus. Virology 379: 256265.CrossRefGoogle ScholarPubMed
Abdul-Careem, MF, Hunter, BD, Sarson, AJ, Parvizi, P, Haghighi, HR, Read, L, Heidari, M and Sharif, S (2008b). Host responses are induced in feathers of chickens infected with Marek's disease virus. Virology 370: 256265.Google Scholar
Abdul-Careem, MF, Read, LR, Parvizi, P, Thanthrige-Don, N and Sharif, S (2009). Marek's disease virus-induced expression of cytokine genes in feathers of genetically defined chickens. Developmental and Comparative Immunology 33: 618623.CrossRefGoogle ScholarPubMed
Abplanalp, H, Schat, KA and Calnek, BW (1984). Genetic resistance to Marek's disease in congenic strains of chickens. In: Calnek, BW and Spencer, JL (eds) Proceedings of International Symposium on Marek's Disease. KennethSquare, PA: American Association of Avian Pathologists, pp. 347358.Google Scholar
Akbari, MR, Haghighi, HR, Chambers, JR, Brisbin, J, Read, LR and Sharif, S (2008). Expression of antimicrobial peptides in cecal tonsils of chickens treated with probiotics and infected with Salmonella. Clinical and Vaccine Immunology 15: 16891693.CrossRefGoogle ScholarPubMed
Bacon, LD and Witter, RL (1993). Influence of B haplotype on the relative efficacy of Marek's disease vaccines of different serotypes. Avian Diseases 37: 5359.CrossRefGoogle ScholarPubMed
Bacon, LD and Witter, RL (1994a). Serotype specificity of B-haplotype influence on the relative efficacy of Marek's disease vaccines. Avian Diseases 38: 6571.Google Scholar
Bacon, LD and Witter, RL (1994b). B haplotype influence on the relative efficacy of Marek's disease vaccines in commercial chickens. Poultry Science 73: 481487.Google Scholar
Bacon, LD and Witter, RL (1995). Efficacy of Marek's disease vaccines in Mhc heterozygous chickens: MHC congenic×inbred line F1 matings. Journal of Heredity 86: 269273.Google Scholar
Bacon, LD, Hunt, HD and Cheng, HH (2001). Genetic resistance to Marek's disease. Current Topics in Microbiology and Immunology 255: 121142.Google Scholar
Baggiolini, M and Clark-Lewis, I (1992). Interleukin-8, a chemotactic and inflammatory cytokine. FEBS letters 307: 97–101.Google Scholar
Baigent, SJ and Davison, F (2004). Marek's disease virus: biology and life cycle. In: Davison, F and Nair, V (eds) Marek's Disease: An Evolving Problem. London: Elsevier, pp. 6278.Google Scholar
Baigent, SJ, Smith, LP, Nair, VK and Currie, RJ (2006). Vaccinal control of Marek's disease: current challenges, and future strategies to maximize protection. Veterinary Immunology and Immunopathology 112: 7886.CrossRefGoogle ScholarPubMed
Barrow, AD, Burgess, SC, Baigent, SJ, Howes, K and Nair, VK (2003). Infection of macrophages by a lymphotropic herpesvirus: a new tropism for Marek's disease virus. Journal of General Virology 84: 26352645.CrossRefGoogle ScholarPubMed
Biely, J, Palmer, VE, Lerner, IM and Asmundson, VS (1933). Inheritance of resistance to fowl paralysis (Neurolymphomatosis Gallinarum). Science (New York, NY) 78: 4251.CrossRefGoogle ScholarPubMed
Biggs, PM (2001). The history and biology of Marek's disease virus. In: Hirai, K (ed.) Marek's Disease. Berlin, Heidelberg, NewYork: Springer-Verlag, pp. 124.Google ScholarPubMed
Biron, CA (1998). Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections. Seminars in Immunology 10: 383390.CrossRefGoogle ScholarPubMed
Bogdan, C (2001). Nitric oxide and the immune response. Nature Immunology 2: 907916.CrossRefGoogle ScholarPubMed
Boyd, A, Philbin, VJ and Smith, AL (2007). Conserved and distinct aspects of the avian Toll-like receptor (TLR) system: implications for transmission and control of bird-borne zoonoses. Biochemical Society Transactions 35: 15041507.Google Scholar
Briles, WE, Stone, HA and Cole, RK (1977). Marek's disease: effects of B histocompatibility alloalleles in resistant and susceptible chicken lines. Science 195: 193195.CrossRefGoogle ScholarPubMed
Bublot, M and Sharma, J (2004). Vaccination against Marek's disease. In: Davison, F and Nair, V (eds) Marek's Disease an Evolving Problem. London: Elsevier, pp. 168185.Google Scholar
Bumstead, N (1998). Genomic mapping of resistance to Marek's disease. Avian Pathology 27: 7881.CrossRefGoogle Scholar
Bumstead, N and Kaufman, J (2004). Genetic resistance to Marek's disease. In: Davison, F and Nair, V (eds) Marek's Disease: An Evolving Problem. London: Elsevier, pp. 112125.CrossRefGoogle Scholar
Burgess, SC, Young, JR, Baaten, BJ, Hunt, L, Ross, LN, Parcells, MS, Kumar, PM, Tregaskes, CA, Lee, LF and Davison, TF (2004). Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30). Proceedings of the National Academy of Sciences of the United States of America 101: 1387913884.Google Scholar
Buscaglia, C, O'Connell, PH, Jarosinski, KW, Pevzner, I and Schat, KA (2009). Selection for increased nitric oxide production does not increase resistance to Marek's disease in a primary broiler breeder line. Avian Diseases 53: 336340.Google Scholar
Buza, JJ and Burgess, SC (2007). Modeling the proteome of a Marek's disease transformed cell line: a natural animal model for CD30 overexpressing lymphomas. Proteomics 7: 13161326.CrossRefGoogle ScholarPubMed
Calnek, BW (1982). Marek's disease vaccines. Developments in Biological Standardization 52: 401405.Google Scholar
Calnek, BW (1986). Marek's disease–a model for herpesvirus oncology. Critical Reviews in Microbiology 12: 293320.CrossRefGoogle ScholarPubMed
Calnek, BW (2001). Pathogenesis of Marek's disease virus infection. In: Hirai, K (ed.) Marek's Disease. Berlin, Heidelberg, New York: Springer-Verlag, pp. 2555.Google Scholar
Calnek, BW, Adldinger, HK and Kahn, DE (1970). Feather follicle epithelium: a source of enveloped and infectious cell-free herpesvirus from Marek's disease. Avian Diseases 14: 219233.Google Scholar
Carriel-Gomes, MC, Kratz, JM, Barracco, MA, Bachere, E, Barardi, CR and Simoes, CM (2007). In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus. Memorias do Instituto Oswaldo Cruz 102: 469472.CrossRefGoogle ScholarPubMed
Chen, X and Velicer, LF (1992). Expression of the Marek's disease virus homolog of herpes simplex virus glycoprotein B in Escherichia coli and its identification as B antigen. Journal of Virology 66: 43904398.Google Scholar
Chen, XB, Sondermeijer, PJ and Velicer, LF (1992). Identification of a unique Marek's disease virus gene which encodes a 38-kilodalton phosphoprotein and is expressed in both lytically infected cells and latently infected lymphoblastoid tumor cells. Journal of Virology 66: 8594.CrossRefGoogle ScholarPubMed
Cheng, HH, Zhang, Y and Muir, WM (2007). Evidence for widespread epistatic interactions influencing Marek's disease virus viremia levels in chicken. Cytogenetic and Genome Research 117: 313318.Google Scholar
Churchill, AE, Chubb, RC and Baxendale, W (1969a). The attenuation, with loss of oncogenicity, of the herpes-type virus of Marek's disease (strain HPRS-16) on passage in cell culture. Journal of General Virology 4: 557564.Google Scholar
Churchill, AE, Payne, LN and Chubb, RC (1969b). Immunization against Marek's disease using a live attenuated virus. Nature 221: 744747.Google Scholar
Cole, RK (1968). Studies on genetic resistance to Marek's disease. Avian Diseases 12: 9–28.Google Scholar
Cui, X, Lee, LF, Reed, WM, Kung, HJ and Reddy, SM (2004). Marek's disease virus-encoded vIL-8 gene is involved in early cytolytic infection but dispensable for establishment of latency. Journal of Virology 78: 47534760.Google Scholar
Cui, ZZ, Lee, LF, Liu, JL and Kung, HJ (1991). Structural analysis and transcriptional mapping of the Marek's disease virus gene encoding pp38, an antigen associated with transformed cells. Journal of Virology 65: 65096515.Google Scholar
Cumberbatch, JA, Brewer, D, Vidavsky, I and Sharif, S (2006). Chicken major histocompatibility complex class II molecules of the B haplotype present self and foreign peptides. Animal Genetics 37: 393396.CrossRefGoogle Scholar
Dalgaard, TS, Hojsgaard, S, Skjodt, K and Juul-Madsen, HR (2003). Differences in chicken major histocompatibility complex (MHC) class I alpha gene expression between Marek's disease-resistant and -susceptible MHC haplotypes. Scandinavian Journal of Immunology 57: 135143.Google Scholar
Davison, F and Kaiser, P (2004). Immunity to Marek's disease. In: Davison, F and Nair, V (eds) Marek's Disease: An Evolving Problem, 1st edn.London: Elsevier, pp. 126139.CrossRefGoogle Scholar
Degen, WG, Daal, N, Rothwell, L, Kaiser, P and Schijns, VE (2005). Th1/Th2 polarization by viral and helminth infection in birds. Veterinary Microbiology 105: 163167.CrossRefGoogle ScholarPubMed
Ding, AH and Lam, KM (1986). Enhancement by interferon of chicken splenocyte natural killer cell activity against Marek's disease tumor cells. Veterinary Immunology and Immunopathology 11: 6572.Google Scholar
Djeraba, A, Musset, E, Bernardet, N, Le Vern, Y and Quéré, P (2002). Similar pattern of iNOS expression, NO production and cytokine response in genetic and vaccination-acquired resistance to Marek's disease. Veterinary Immunology and Immunopathology 85: 6375.Google Scholar
Fukui, A, Inoue, N, Matsumoto, M, Nomura, M, Yamada, K, Matsuda, Y, Toyoshima, K and Seya, T (2001). Molecular cloning and functional characterization of chicken toll-like receptors. A single chicken toll covers multiple molecular patterns. Journal of Biological Chemistry 276: 4714347149.CrossRefGoogle ScholarPubMed
Ganz, T (2003). Defensins: antimicrobial peptides of innate immunity. Nature Reviews Immunology 3: 710720.Google Scholar
Garcia-Camacho, L, Schat, KA, Brooks, R Jr and Bounous, DI (2003). Early cell-mediated immune responses to Marek's disease virus in two chicken lines with defined major histocompatibility complex antigens. Veterinary Immunology and Immunopathology 95: 145153.Google Scholar
Gavora, JS and Spencer, JL (1979). Studies on genetic resistance of chickens to Marek's disease: a review. Comparative Immunology, Microbiology and Infectious Diseases 2: 359371.CrossRefGoogle ScholarPubMed
Giansanti, F, Giardi, MF and Botti, D (2006). Avian cytokines: an overview. Current Pharmaceutical Design 12: 30833099.Google Scholar
Gimeno, IM (2008). Marek's disease vaccines: a solution for today but a worry for tomorrow? Vaccine 26: C31C41.Google Scholar
Gimeno, IM, Witter, RL, Hunt, HD, Reddy, SM and Reed, WM (2004). Biocharacteristics shared by highly protective vaccines against Marek's disease. Avian Pathology 33: 5968.Google Scholar
Haeri, M, Read, LR, Wilkie, BN and Sharif, S (2005). Identification of peptides associated with chicken major histocompatibility complex class II molecules of B21 and B19 haplotypes. Immunogenetics 56: 854859.Google Scholar
Heidari, M, Huebner, M, Kireev, D and Silva, RF (2008). Transcriptional profiling of Marek's disease virus genes during cytolytic and latent infection. Virus Genes 36: 383392.Google Scholar
Heifetz, EM, Fulton, JE, O'Sullivan, NP, Arthur, JA, Wang, J, Dekkers, JCM and Soller, M (2007). Mapping quantitative trait loci affecting susceptibility to Marek's disease virus in a backcross population of layer chickens. Genetics 177: 24172431.Google Scholar
Heifetz, EM, Fulton, JE, O'Sullivan, NP, Arthur, JA, Cheng, H, Wang, J, Soller, M and Dekkers, JC (2009). Mapping QTL affecting resistance to Marek's disease in an F6 advanced intercross population of commercial layer chickens. BMC Genomics 10: 117.Google Scholar
Heller, ED and Schat, KA (1987). Enhancement of natural killer cell activity by Marek's disease vaccines. Avian Pathology 16: 5160.CrossRefGoogle ScholarPubMed
Hepkema, BG, Blankert, JJ, Albers, GAA, Tilanus, MGJ, Egberts, E, Vanderzijpp, AJ and Hensen, EJ (1993). Mapping of susceptibility to Marek's disease within the major histocompatibility (B) complex by refined typing of white leghorn chickens. Animal Genetics 24: 283287.Google Scholar
Islam, A and Walkden-Brown, SW (2007). Quantitative profiling of the shedding rate of the three Marek's disease virus (MDV) serotypes reveals that challenge with virulent MDV markedly increases shedding of vaccinal viruses. Journal of General Virology 88: 21212128.Google Scholar
Jarosinski, KW, Jia, W, Sekellick, MJ, Marcus, PI and Schat, KA (2001). Cellular responses in chickens treated with IFN-alpha orally or inoculated with recombinant Marek's disease virus expressing IFN-alpha. Interferon Cytokine Research 21: 287296.Google Scholar
Jarosinski, KW, Yunis, R, O'Connell, PH, Markowski-Grimsrud, CJ and Schat, KA (2002). Influence of genetic resistance of the chicken and virulence of Marek's disease virus (MDV) on nitric oxide responses after MDV infection. Avian Diseases 46: 636649.CrossRefGoogle ScholarPubMed
Jarosinski, KW, Njaa, BL, O'Connell, PH and Schat, KA (2005). Pro-inflammatory responses in chicken spleen and brain tissues after infection with very virulent plus Marek's disease virus. Viral Immunology 18: 148161.Google Scholar
Jenkins, KA, Lowenthal, JW, Kimpton, W and Bean, AG (2009). The in vitro and in ovo responses of chickens to TLR9 subfamily ligands. Developmental and Comparative Immunology 33: 660667.Google Scholar
Johnson, EA, Burke, CN, Fredrickson, TN and DiCapua, RA (1975). Morphogenesis of Marek's disease virus in feather follicle epithelium. Journal of National Cancer Institute 55: 8999.CrossRefGoogle ScholarPubMed
Juul-Madsen, HR, Dalgaard, TS and Afanassieff, M (2000). Molecular characterization of major and minor MHC class I and II genes in B-21-like haplotypes in chickens. Animal Genetics 31: 252261.Google Scholar
Kaiser, P, Underwood, G and Davison, F (2003). Differential cytokine responses following Marek's disease virus infection of chickens differing in resistance to Marek's disease. Journal of Virology 77: 762768.Google Scholar
Kaiser, P, Rothwell, L, Avery, S and Balu, S (2004). Evolution of the interleukins. Developmental and Comparative Immunology 28: 375394.Google Scholar
Kaiser, P, Poh, TY, Rothwell, L, Avery, S, Balu, S, Pathania, US, Hughes, S, Goodchild, M, Morrell, S, Watson, M, Bumstead, N, Kaufman, J and Young, JR (2005). A genomic analysis of chicken cytokines and chemokines. Journal of Interferon and Cytokine Research 25: 467484.Google Scholar
Kano, R, Konnai, S, Onuma, M and Ohashi, K (2009). Cytokine profiles in chickens infected with virulent and avirulent Marek's disease viruses: interferon-gamma is a key factor in the protection of Marek's disease by vaccination. Microbiology and Immunology 53: 224232.Google Scholar
Karaca, G, Anobile, J, Downs, D, Burnside, J and Schmidt, CJ (2004). Herpesvirus of turkeys: microarray analysis of host gene responses to infection. Virology 318: 102111.Google Scholar
Karpala, AJ, Lowenthal, JW and Bean, AG (2008). Activation of the TLR3 pathway regulates IFNbeta production in chickens. Developmental and Comparative Immunology 32: 435444.CrossRefGoogle ScholarPubMed
Kaufman, J and Salomonsen, J (1997). The “Minimal Essential MHC” revisited: both peptide-binding and cell surface expression level of MHC molecules are polymorphisms selected by pathogens in chickens. Hereditas 127: 6773.Google Scholar
Kaufman, J, Volk, H and Wallny, HJ (1995). A “Minimal Essential MHC” and an “unrecognized MHC”: two extremes in selection for polymorphism. Immunological Reviews 143: 6388.Google Scholar
Kaufman, J, Milne, S, Goebel, TW, Walker, BA, Jacob, JP, Auffray, C, Zoorob, R and Beck, S (1999). The chicken B locus is a minimal essential major histocompatibility complex. Nature 401: 923925.Google Scholar
Kindt, TJ, Goldsby, RA and Osborne, BA (2007). Chapter 2: Cells and organs of the immune system. In Immunology, 6th edn. W.H. Freeman and Company, NewYork, 2352.Google Scholar
Koch, M, Camp, S, Collen, T, Avila, D, Salomonsen, J, Wallny, HJ, Van Hateren, A, Hunt, L, Jacob, JP, Johnston, F, Marston, DA, Shaw, I, Dunbar, PR, Cerundolo, V, Jones, EY and Kaufman, J (2007). Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. Immunity 27: 885899.Google Scholar
Kogut, MH, Iqbal, M, He, H, Philbin, V, Kaiser, P and Smith, A (2005). Expression and function of Toll-like receptors in chicken heterophils. Developmental and Comparative Immunology 29: 791807.Google Scholar
Kumar, S, Buza, JJ and Burgess, SC (2009). Genotype-dependent tumor regression in Marek's disease mediated at the level of tumor immunity. Cancer Microenvironment 2: 2331.CrossRefGoogle ScholarPubMed
Leite-De-Moraes, MC, Hameg, A, Pacilio, M, Koezuka, Y, Taniguchi, M, Van Kaer, L, Schneider, E, Dy, M and Herbelin, A (2001). IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells. Journal of Immunology 166: 945951.Google Scholar
Li, S, Zadworny, D, Aggrey, SE and Kuhnlein, U (1998). Mitochondrial PEPCK: a highly polymorphic gene with alleles co-selected with Marek's disease resistance in chickens. Animal Genetics 29: 395397.CrossRefGoogle ScholarPubMed
Lillehoj, HS, Lillehoj, EP, Weinstock, D and Schat, KA (1988). Functional and biochemical characterizations of avian T lymphocyte antigens identified by monoclonal antibodies. European Journal of Immunology 18: 20592065.Google Scholar
Lipkin, E, Fulton, J, Cheng, H, Yonash, N and Soller, M (2002). Quantitative trait locus mapping in chickens by selective DNA pooling with dinucleotide microsatellite markers by using purified DNA and fresh or frozen red blood cells as applied to marker-assisted selection. Poultry Science 81: 283292.CrossRefGoogle ScholarPubMed
Liu, HC, Cheng, HH, Tirunagaru, V, Sofer, L and Burnside, J (2001a). A strategy to identify positional candidate genes conferring Marek's disease resistance by integrating DNA microarrays and genetic mapping. Animal Genetics 32: 351359.Google Scholar
Liu, HC, Kung, HJ, Fulton, JE, Morgan, RW and Cheng, HH (2001b). Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken. Proceedings of the National Academy of Sciences of the United States of America 98: 9203–8.Google Scholar
Liu, HC, Niikura, M, Fulton, JE and Cheng, HH (2003). Identification of chicken lymphocyte antigen 6 complex, locus E (LY6E, alias SCA2) as a putative Marek's disease resistance gene via a virus-host protein interaction screen. Cytogenetic and Genome Research 102: 304308.Google Scholar
Liu, JL, Lin, SF, Xia, L, Brunovskis, P, Li, D, Davidson, I, Lee, LF and Kung, HJ (1999). MEQ and V-IL8: cellular genes in disguise? Acta Virologica 43: 94–101.Google Scholar
Maccubbin, DL and Schierman, LW (1986). MHC-restricted cytotoxic response of chicken T cells: expression, augmentation, and clonal characterization. Journal of Immunology 136: 1216.Google Scholar
Maneechotesuwan, K, Xin, Y, Ito, K, Jazrawi, E, Lee, KY, Usmani, OS, Barnes, PJ and Adcock, IM (2007). Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. Journal of Immunology 178: 24912498.Google Scholar
Marek, J (1907). Multiple Nervenentzündung (Polyneuritis) bei Hühnern. Deutsche Tierärztliche Wochenschrift 15: 417421.Google Scholar
Markowski-Grimsrud, CJ and Schat, KA (2002). Cytotoxic T lymphocyte responses to Marek's disease herpesvirus-encoded glycoproteins. Veterinary Immunology and Immunopathology 90: 133144.Google Scholar
McElroy, JP, Dekkers, JCM, Fulton, JE, O'Sullivan, NP, Soller, M, Lipkin, E, Zhang, W, Koehler, KJ, Lamont, SJ and Cheng, HH (2005). Microsatellite markers associated with resistance to Marek's disease in commercial layer chickens. Poultry Science 84: 16781688.Google Scholar
Merkle, H, Cihak, J and Losch, U (1992). The cytotoxic T lymphocyte response in reticuloendotheliosis virus-infected chickens is mediated by alpha beta and not by gamma delta T cells. Immunobiology 186: 292303.Google Scholar
Mester, JC and Rouse, BT (1991). The mouse model and understanding immunity to herpes simplex virus. Reviews of Infectious Diseases 13: S935–45.Google Scholar
Mester, JC, Highlander, SL, Osmand, AP, Glorioso, JC and Rouse, BT (1990). Herpes simplex virus type 1-specific immunity induced by peptides corresponding to an antigenic site of glycoprotein B. Journal of Virology 64: 52775283.Google Scholar
Morgan, RW, Sofer, L, Anderson, AS, Bernberg, EL, Cui, J and Burnside, J (2001). Induction of host gene expression following infection of chicken embryo fibroblasts with oncogenic Marek's disease virus. Journal of Virology 75: 533539.Google Scholar
Morimura, T, Ohashi, K, Kon, Y, Hattori, M, Sugimoto, C and Onuma, M (1997). Apoptosis in peripheral CD4+T cells and thymocytes by Marek's disease virus-infection. Leukemia 11: 206208.Google Scholar
Morrow, C and Fehler, F (2004). Marek's disease: a worldwide problem. In: Davison, F and Nair, V (eds) Marek's Disease: An Evolving Problem. London: Elsevier, pp. 4961.Google Scholar
Mossman, KL and Ashkar, AA (2005). Herpesviruses and the innate immune response. Viral Immunology 18: 267281.Google Scholar
Nazerian, K, Lee, LF, Yanagida, N and Ogawa, R (1992). Protection against Marek's disease by a fowlpox virus recombinant expressing the glycoprotein B of Marek's disease virus. Journal of Virology 66: 14091413.Google Scholar
Niemiec, PK, Read, LR and Sharif, S (2006). Synthesis of chicken major histocompatibility complex class II oligomers using a baculovirus expression system. Protein Expression and Purification 46: 390400.Google Scholar
Okazaki, W, Purchase, HG and Burmester, BR (1970). Protection against Marek's disease by vaccination with a herpesvirus of turkeys. Avian Diseases 14: 413429.Google Scholar
Omar, AR and Schat, KA (1996). Syngeneic Marek's disease virus (MDV)-specific cell-mediated immune responses against immediate early, late, and unique MDV proteins. Virology 222: 8799.Google Scholar
Omar, AR and Schat, KA (1997). Characterization of Marek's disease herpesvirus-specific cytotoxic T lymphocytes in chickens inoculated with a non-oncogenic vaccine strain of MDV. Immunology 90: 579585.Google Scholar
Omar, AR, Schat, KA, Lee, LF and Hunt, HD (1998). Cytotoxic T lymphocyte response in chickens immunized with a recombinant fowlpox virus expressing Marek's disease herpesvirus glycoprotein B. Veterinary Immunology and Immunopathology 62: 7382.Google Scholar
Ono, M, Maeda, K, Kawaguchi, Y, Jang, HK, Tohya, Y, Niikura, M and Mikami, T (1995). Expression of Marek's disease virus (MDV) serotype 2 gene which has partial homology with MDV serotype 1 pp38 gene. Virus Research 35: 223229.Google Scholar
Osterrieder, K and Vautherot, JF (2004). The genome content of Marek's disease-like viruses. In: Davison, F and Nair, V (eds) Marek's Disease an Evolving Problem. London: Elsevier, pp. 1729.Google Scholar
Parcells, MS, Lin, SF, Dienglewicz, RL, Majerciak, V, Robinson, DR, Chen, HC, Wu, Z, Dubyak, GR, Brunovskis, P, Hunt, HD, Lee, LF and Kung, HJ (2001). Marek's disease virus (MDV) encodes an interleukin-8 homolog (vIL-8): characterization of the vIL-8 protein and a vIL-8 deletion mutant MDV. Journal of Virology 75: 51595173.Google Scholar
Parvizi, P, Read, LR, Abdul-Careem, MF, Sarson, AJ, Lusty, C, Lambourne, M, Thanthrige-Don, N, Burgess, SC and Sharif, S (2009a). Cytokine gene expression in splenic CD4+ and CD8+ T cell subsets of genetically-resistant and susceptible chickens infected with Marek's disease virus. Veterinary Immunology and Immunopathology 132: 209–17.Google Scholar
Parvizi, P, Read, L, Abdul-Careem, MF, Lusty, C and Sharif, S (2009b). Cytokine gene expression in splenic CD4(+) and CD8(+) T-cell subsets of chickens infected with Marek's disease virus. Viral Immunology 22: 3138.Google Scholar
Praslickova, D, Sharif, S, Sarson, A, Abdul-Careem, MF, Zadworny, D, Kulenkamp, A, Ansah, G and Kuhnlein, U (2008). Association of a marker in the vitamin D receptor gene with Marek's disease resistance in poultry. Poultry Science 87: 11121119.Google Scholar
Pratt, WD, Morgan, R and Schat, KA (1992). Cell-mediated cytolysis of lymphoblastoid cells expressing Marek's disease virus-specific phosphorylated polypeptides. Veterinary Microbiology 33: 9399.Google Scholar
Quéré, P, Rivas, C, Ester, K, Novak, R and Ragland, WL (2005). Abundance of IFN-alpha and IFN-gamma mRNA in blood of resistant and susceptible chickens infected with Marek's disease virus (MDV) or vaccinated with turkey herpesvirus; and MDV inhibition of subsequent induction of IFN gene transcription. Archives of Virology 150: 507519.Google Scholar
Qureshi, MA, Heggen, CL and Hussain, I (2000). Avian macrophage: effector functions in health and disease. Developmental and Comparative Immunology 24: 103119.Google Scholar
Rispens, BH, Van Vloten, H, Mastenbroek, N, Maas, HJ and Schat, KA (1972a). Control of Marek's disease in the Netherlands. I. Isolation of an avirulent Marek's disease virus (strain CVI 988) and its use in laboratory vaccination trials. Avian Diseases 16: 108125.Google Scholar
Rispens, BH, Van Vloten, H, Mastenbroek, N, Maas, JL and Schat, KA (1972b). Control of Marek's disease in the Netherlands. II. Field trials on vaccination with an avirulent strain (CVI 988) of Marek's disease virus. Avian Diseases 16: 126138.Google Scholar
Ross, LJ (1977). Antiviral T cell-mediated immunity in Marek's disease. Nature 268: 644646.Google Scholar
Rothwell, L, Young, JR, Zoorob, R, Whittaker, CA, Hesketh, P, Archer, A, Smith, AL and Kaiser, P (2004). Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima. Journal of Immunology 173: 26752682.Google Scholar
Sarson, AJ, Abdul-Careem, MF, Zhou, H and Sharif, S (2006). Transcriptional analysis of host responses to Marek's disease viral infection. Viral Immunology 19: 747758.Google Scholar
Sarson, AJ, Abdul-Careem, MF, Read, LR, Brisbin, JT and Sharif, S (2008a). Expression of cytotoxicity-associated genes in Marek's disease virus-infected chickens. Viral Immunology 21: 267272.CrossRefGoogle ScholarPubMed
Sarson, AJ, Parvizi, P, Lepp, D, Quinton, M and Sharif, S (2008b). Transcriptional analysis of host responses to Marek's disease virus infection in genetically resistant and susceptible chickens. Animal Genetics 39: 232240.Google Scholar
Schat, KA and Baranowski, E (2007). Animal vaccination and the evolution of viral pathogens. Revue Scientifique et Technique (International Office of Epizootics) 26: 327338.Google Scholar
Schat, KA and Calnek, BW (1978). Protection against Marek's disease-derived tumor transplants by the nononcogenic SB-1 strain of Marek's disease virus. Infection and Immunity 22: 225232.Google Scholar
Schat, KA and Davies, C (2000). Resistance to viral diseases. In: Axford, RFE, Owen, JB and Nicholas, F (eds) Breeding for Disease Resistance in Farm Animals, 2nd edn.Wallingford, UK: CAB International, pp. 271300.Google Scholar
Schat, KA and Xing, Z (2000). Specific and nonspecific immune responses to Marek's disease virus. Developmental and Comparative Immunology 24: 201221.Google Scholar
Schat, KA and Markowski-Grimsrud, CJ (2001). Immune responses to Marek's disease virus infection. Current Topics in Microbiology and Immunology 255: 91–120.Google Scholar
Schat, KA and Nair, V (2008). Marek's disease. In: Saif, YM, Fadly, AM, Glisson, JR, McDougald, LR, Nolan, LK and Swayne, DE (eds) Diseases of Poultry, 12th edn. Iowa State Press, US, Wiley-Blackwell, pp. 458520.Google Scholar
Schat, KA, Chen, CL, Shek, WR and Calnek, BW (1982). Surface antigens on Marek's disease lymphoblastoid tumor cell lines. Journal of the National Cancer Institute 69: 715720.Google Scholar
Schat, KA, Pratt, WD, Morgan, R, Weinstock, D and Calnek, BW (1992). Stable transfection of reticuloendotheliosis virus-transformed lymphoblastoid cell lines. Avian Diseases 36: 432439.Google Scholar
Schwarz, H, Schneider, K, Ohnemus, A, Lavric, M, Kothlow, S, Bauer, S, Kaspers, B and Staeheli, P (2007). Chicken Toll-like receptor 3 recognizes its cognate ligand when ectopically expressed in human cells. Journal of Interferon and Cytokine Research 27: 97–101.CrossRefGoogle ScholarPubMed
Selsted, ME and Ouellette, AJ (2005). Mammalian defensins in the antimicrobial immune response. Nature Immunology 6: 551557.Google Scholar
Sharma, JM and Burmester, BR (1982). Resistance to Marek's disease at hatching in chickens vaccinated as embryos with the turkey herpesvirus. Avian Diseases 26: 134149.Google Scholar
Sharma, JM and Okazaki, W (1981). Natural killer cell activity in chickens: target cell analysis and effect of antithymocyte serum on effector cells. Infection and Immunity 31: 10781085.Google Scholar
Smith, GD, Zelnik, V and Ross, LJ (1995). Gene organization in herpesvirus of turkeys: identification of a novel open reading frame in the long unique region and a truncated homologue of pp38 in the internal repeat. Virology 207: 205216.Google Scholar
Tarpey, I, Davis, PJ, Sondermeijer, P, Van Geffen, C, Verstegen, I, Schijns, VEJC, Kolodsick, J and Sundick, R (2007). Expression of chickens interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge. Avian Pathology 36: 6974.Google Scholar
Uni, Z, Pratt, WD, Miller, MM, O'Connell, PH and Schat, KA (1994). Syngeneic lysis of reticuloendotheliosis virus-transformed cell lines transfected with Marek's disease virus genes by virus-specific cytotoxic T cells. Veterinary Immunology and Immunopathology 44: 5769.Google Scholar
Vallejo, RL, Bacon, LD, Liu, H, Witter, RL, Groenen, MAM, Hillel, J and Cheng, HH (1998). Genetic mapping of quantitative trait loci affecting susceptibility to Marek's disease virus induced tumors in F sub(2) intercross chickens. Genetics 148: 349360.Google Scholar
Weinstock, D, Schat, KA and Calnek, BW (1989). Cytotoxic T lymphocytes in reticuloendotheliosis virus-infected chickens. European Journal of Immunology 19: 267272.Google Scholar
Witter, RL (2001). Protective efficacy of Marek's disease vaccines. In: Hirai, K (ed.) Marek's Disease. Berlin, Heidelberg, New York: Springer-Verlag, pp. 5791.Google Scholar
Witter, RL and Kreager, KS (2004). Serotype 1 viruses modified by backpassage or insertional mutagenesis:approaching the threshold of vaccine efficacy in Marek's disease. Avian Diseases 48: 768782.Google Scholar
Witter, RL, Nazerian, K, Purchase, HG and Burgoyne, GH (1970). Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek's disease virus. American Journal of Veterinary Research 31: 525538.Google ScholarPubMed
Xing, Z and Schat, KA (2000a). Inhibitory effects of nitric oxide and gamma interferon on in vitro and in vivo replication of Marek's disease virus. Journal of Virology 74: 36053612.Google Scholar
Xing, Z and Schat, KA (2000b). Expression of cytokine genes in Marek's disease virus-infected chickens and chicken embryo fibroblast cultures. Immunology 100: 7076.Google Scholar
Xu, S, Yonash, N, Vallejo, RL and Cheng, HH (1998). Mapping quantitative trait loci for binary traits using a heterogeneous residual variance model: an application to Marek's disease susceptibility in chickens. Genetica 104: 171178.Google Scholar
Yu, Y, Zhang, H, Tian, F, Zhang, W, Fang, H and Song, J (2008). An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines. PLoS ONE 3: 26722685.Google Scholar