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The development of oral fluid-based diagnostics and applications in veterinary medicine

Published online by Cambridge University Press:  05 March 2010

John R. Prickett*
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
Jeffrey J. Zimmerman
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
*
*Corresponding author. E-mail: [email protected]

Abstract

The purpose of this review was to discuss the history of the development and implementation of oral fluid diagnostics for infectious diseases of humans and domestic animals. The use of oral fluid for the assessment of health and diagnosis of disease in humans and animals has a surprisingly long history. As early as 1909, Pollaci and Ceraulo reported sensitive and specific agglutination of ‘Micrococcus melitensis’ (Brucella melitensis) by oral fluid from patients diagnosed with Malta Fever. A 1986 report of the detection of antibodies against human immunodeficiency virus (HIV) in oral fluid from patients with acquired immunodeficiency syndrome (AIDS) marked the start of a remarkably rapid series of developments in oral fluid-based assays. Cumulatively, the literature strongly supports implementation of oral fluid-based diagnostics in veterinary diagnostic medicine. Pathogen-specific IgA, IgM and IgG antibodies have all been demonstrated in oral fluid collected from diverse domestic animal species in response to infection. A variety of infectious agents, both local and systemic, are shed in oral fluid, including some of the most economically significant pathogens of production animals (e.g. foot-and-mouth disease virus, classical swine fever virus and porcine reproductive and respiratory syndrome virus) Ultimately, point-of-care rapid assays (i.e. cow-side, sow-side or pen-side tests) and access to real-time infectious disease data will revolutionize our delivery of health management services.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2010

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References

Amado, LA, Villar, LM, de Paula, VS, de Almeida, AJ and Gaspar, AMC (2006). Detection of hepatitis A, B, and C virus-specific antibodies using oral fluid for epidemiological studies. Memórias do Instituto Oswaldo Cruz 101: 149155.CrossRefGoogle Scholar
Archetti, I, Amadori, M, Donn, A, Salt, J and Lodetti, E (1995). Detection of foot-and-mouth disease virus-infected cattle by assessment of antibody response in oropharyngeal fluids. Journal of Clinical Microbiology 33: 7984.CrossRefGoogle ScholarPubMed
Archibald, DW, Zon, L, Groopman, JE, McLane, MF and Essex, M (1986). Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS. Blood 67: 831834.CrossRefGoogle ScholarPubMed
Atkinson, J, Dawes, C, Ericson, T, Fox, PC, Gandara, BK, Malamud, D, Mandel, ID, Navazesch, M and Tabak, LA (1993). Guidelines for saliva nomenclature and collection. Annals of the New York Academy of Sciences 694: xixii.Google Scholar
Baguley, SDK, Horner, PJ, Maple, PAC and Stephenson, L (2005). An oral fluid test for syphilis. International Journal of STD and AIDS 16: 299301.CrossRefGoogle ScholarPubMed
Beckenkamp, G (1985). Distribution pattern of the cellular oral immune system in the major and minor salivary glands, immunochemical findings. HNO 33: 196203.Google Scholar
Ben Salah, A, Zaâtour, A, Pomery, L, Cohen, BJ, Brown, DW and Andrews, N (2003). Validation of a modified commercial assay for the detection of rubella-specific IgG in oral fluid for use in population studies. Journal of Virological Methods 114: 151158.CrossRefGoogle ScholarPubMed
Berger, R, Ainbender, E, Hodes, HL, Zepp, HD and Hevizy, MM (1967). Demonstration of IgA polioantibody in saliva, duodenal fluid and urine. Nature 214: 420422.CrossRefGoogle ScholarPubMed
Brandtzaeg, P (1975). Human secretory immunoglobulin M an immunochemical and immunohistochemical study. Immunology 29: 559570.Google ScholarPubMed
Brandtzaeg, P (1981). Transport models for secretory IgA and secretory IgM. Clinical and Experimental Immunology 44: 221232.Google ScholarPubMed
Brandtzaeg, P (1989). Salivary immunoglobulins. In: Tenovuo, JO (ed.) Human Saliva: Clinical Chemistry and Microbiology. Boca Raton, FL: CRC Press, pp. 151.Google Scholar
Branson, B (2007). State of the art for diagnosis of HIV infection. Clinical Infectious Diseases 45 (suppl. 4): S221S225.CrossRefGoogle ScholarPubMed
Brill, N and Björn, H (1959). Passage of tissue fluid into human gingival pockets. Acta Odontologica Scandinavica 17: 1121.CrossRefGoogle Scholar
Brill, N and Krasse, BO (1958). The passage of tissue fluid into the clinically healthy gingival pocket. Acta Odontologica Scandinavica 16: 233245.CrossRefGoogle Scholar
Brown, DWG, Ramsay, ME, Richards, AF and Miller, E (1994). Salivary diagnosis of measles: a study of notified cases in the United Kingdom, 1991–3. British Medical Journal 308: 10151017.CrossRefGoogle ScholarPubMed
Cameron, SO and Carman, WF (2005). The use of Orasure® collection device for hepatitis virus testing in health care settings. Journal of Clinical Virology 34 (suppl. 1): S22S28.CrossRefGoogle ScholarPubMed
Challacombe, S, Percival, R and Marsh, P (1995). Age-related changes in Immunoglobulin isotypes in whole and parotid saliva and serum in healthy individuals. Oral Microbiology and Immunology 10: 202207.CrossRefGoogle ScholarPubMed
Challacombe, S, Rahman, D and O'Hagan, D (1997). Salivary, gut, vaginal and nasal antibody responses after oral immunization with biodegradable microparticles. Vaccine 15: 169175.CrossRefGoogle ScholarPubMed
Challacombe, S, Russel, M, Hawkes, J, Bergmeier, L and Lehner, T (1978). Passage of immunoglobulins from plasma to the oral cavity in rhesus monkeys. Immunology 35: 923931.Google Scholar
Chang, CK, Cohen, ME and Bienek, DR (2009). Efficiency of oral fluid collection devices in extracting antibodies. Oral Microbiology and Immunology 24: 231235.CrossRefGoogle ScholarPubMed
Chiappin, S, Antonelli, G, Gatti, R and De Palo, EF (2007). Saliva specimen: A new laboratory tool for diagnostic and basic investigation. Clinica Chimica Acta 383: 3040.CrossRefGoogle ScholarPubMed
Chiba, Y and Nakao, T (1972). Mumps virus neutralizing antibody in saliva following natural infection. The Tohoku Journal of Experimental Medicine 106: 7581.CrossRefGoogle ScholarPubMed
Coleman, R and Appleman, M (1953). Antibodies of syphilis in saliva and serum. Journal of Dental Research 32: 294297.CrossRefGoogle ScholarPubMed
Collot, S, Petit, B, Bordessoule, D, Alain, S, Touati, M, Denis, F and Ranger-Rogez, S (2002). Real-time PCR for quantification of human herpesvirus 6 DNA from lymph nodes and saliva. Journal of Clinical Microbiology 40: 24452451.CrossRefGoogle ScholarPubMed
Connolly, C, Shisana, O, Colvin, M and Stoker, D (2004). Epidemiology of HIV in South Africa – results of a national, community-based survey. South African Medical Journal 94: 776781.Google ScholarPubMed
Côrtes, V, de Oliveira, M and Peixoto, Z (1979). Use of saliva in the diagnosis of natural canine rabies. Arquivos do Instituto Biológico 46: 131133.Google ScholarPubMed
Corthier, G (1976). Swine fever: influence of passive immunity on pig immune response following vaccination with a live virus vaccine (Thiverval strain). Annals of Veterinary Research 7: 361372.Google ScholarPubMed
Corthier, G and Aynaud, J (1977). Comparison of the immune response in serum and bucco-pharyngeal secretions following immunization by different routes with a live hog cholera virus vaccine (Thiverval strain). Annals of Veterinary Research 8: 159165.Google ScholarPubMed
Crawford, J, Taubman, M and Smith, D (1975). Minor salivary glands as a major source of secretory immunoglobulin A in the human oral cavity. Science 190: 12061209.CrossRefGoogle Scholar
Cuzzubbo, AJ, Vaughn, DW, Nisalak, A, Suntayakorn, S, Aaskov, J and Devine, PL (1998). Detection of specific antibodies in saliva during Dengue infection. Journal of Clinical Microbiology 36: 37373739.CrossRefGoogle ScholarPubMed
de Azevedo Neto, R, Richards, A, Nokes, D, Silveira, A, Cohen, B, Passos, S, de Souza, V, Brown, D, Pannuti, C and Massad, E (1995). Salivary antibody detection in epidemiological surveys: a pilot study after a mass vaccination campaign against rubella in São Paulo, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 89: 115118.CrossRefGoogle ScholarPubMed
da Silva, MV, Dias Camargo, E, Vaz, AJ and Batista, L (1992). Immunodiagnosis of human leptospirosis using saliva. Transactions of the Royal Society of Tropical Medicine and Hygiene 86: 560561.CrossRefGoogle ScholarPubMed
Dean, R, Helps, C, Gruffydd Jones, TJ and Tasker, S (2008). Use of real-time PCR to detect Mycoplasma haemofelis and ‘Candidatus Mycoplasma haemominutum’ in the saliva and salivary glands of haemoplasma-infected cats. Journal of Feline Medicine and Surgery 10: 413417.CrossRefGoogle ScholarPubMed
DeBuysscher, E and Berman, D (1980). Secretory immune response in intestinal mucosa and salivary gland after experimental infection of pigs with transmissible gastroenteritis virus. American Journal of Veterinary Research 41: 12141220.Google ScholarPubMed
DeBuysscher, E and Dubois, R (1978). Detection of IgA anti-Escherichia coli plasma cells in the intestine and salivary glands of pigs orally and locally infected with E. coli. Advances in Experimental Medicine and Biology 107: 593600.CrossRefGoogle Scholar
Delima, AJ and Van Dyke, TE (2003). Origin and function of the cellular components in gingival crevice fluid. Periodontology 2000 31: 5576.CrossRefGoogle ScholarPubMed
Duncan, A, Maggi, R and Breitschwerdt, E (2007). Bartonella DNA in dog saliva. Emerging Infectious Diseases 13: 19481950.CrossRefGoogle ScholarPubMed
Eblé, P, Bouma, A, de Bruin, M, van Hemert-Kluitenberg, F, Van Oirschot, J and Dekker, A (2004). Vaccination of pigs two weeks before infection significantly reduces transmission of foot-and-mouth disease virus. Vaccine 22: 13721378.CrossRefGoogle ScholarPubMed
Ellison, SA, Mashimo, PA and Mandel, ID (1960). Immunochemical studies of human saliva. Journal of Dental Research 39: 892898.CrossRefGoogle ScholarPubMed
Fekadu, M, Shaddock, J and Baer, G (1982). Excretion of rabies virus in the saliva of dogs. Journal of Infectious Diseases 145: 715719.CrossRefGoogle ScholarPubMed
Figueroa, F, Ohlbaum, A and Contreras, G (1973). Neutralizing antibody response in bovine serum and nasal and salivary secretions after immunization with live or inactivated food-and-mouth disease virus. Infection and Immunity 8: 296298.CrossRefGoogle ScholarPubMed
Formenty, P, Leroy, EM, Epelboin, A, Libama, F, Lenzi, M, Sudeck, H, Yaba, P, Allarangar, Y, Boumandouki, P, Nkounkou, VB, Drosten, C, Grolla, A, Feldmann, H and Roth, C (2006). Detection of Ebola virus in oral fluid specimens during outbreaks of Ebola virus hemorrhagic fever in the Republic of Congo. Clinical Infectious Diseases 42: 15211526.CrossRefGoogle ScholarPubMed
Frankova, V and Sixtova, E (1987). Specific IgM antibodies in the saliva of mumps patients. Acta Virologica 31: 357364.Google ScholarPubMed
Frerichs, R, Silarug, N, Eskes, N, Pagcharoenpol, P, Rodklai, A, Thangsupachai, S and Wongba, C (1994). Saliva-based HIV-antibody testing in Thailand. AIDS 8: 885894.CrossRefGoogle ScholarPubMed
Furuta, Y, Aizawa, H, Ohtani, F, Sawa, H and Fukuda, S (2004). Varicella–Zoster virus DNA level and facial paralysis in Ramsay Hunt syndrome. Annals of Otology, Rhinology, and Laryngology 113: 700705.CrossRefGoogle ScholarPubMed
Fylkesnes, K and Kasumba, K (1998). The first Zambian population-based HIV survey: saliva-based testing is accurate and acceptable. AIDS 12: 540541.Google ScholarPubMed
Genco, R, Yecies, L and Karush, F (1969). The immunoglobulins of equine colostrum and parotid fluid. Journal of Immunology 103: 437444.CrossRefGoogle ScholarPubMed
German, A, Hall, E and Day, M (1998). Measurement of IgG, IgM and IgA concentrations in canine serum, saliva, tears and bile. Veterinary Immunology and Immunopathology 64: 107121.CrossRefGoogle ScholarPubMed
Gomes-Keller, M, Tandon, R, Riondato, F, Gönczi, M, Meli, M, Hofmann-Lehmann, R and Lutz, H (2006a). Detection of feline leukemia virus RNA in saliva from naturally infected cats and correlation of PCR results with those of current diagnostic methods. Journal of Clinical Microbiology 44: 916922.CrossRefGoogle ScholarPubMed
Gomes-Keller, M, Tandon, R, Gönczi, E, Meli, M, Hofmann-Lehmann, R and Lutz, H (2006b). Shedding of feline leukemia virus RNA in saliva is a consistent feature in viremic cats. Veterinary Microbiology 112: 1121.CrossRefGoogle ScholarPubMed
Grönblad, EA and Mäkelä, O (1986). Salivary and serum antibodies in patients with Yersinia enterocolitica infection. Microbial Pathogenesis 1: 565571.CrossRefGoogle ScholarPubMed
Groopman, J, Salahuddin, S, Sarngadharan, M, Markham, P, Gonda, M, Sliski, A and Gallo, R (1984). HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS. Science 226: 447449.CrossRefGoogle ScholarPubMed
Habel, RE (1975). Ruminant digestive system. In: Getty, R, Rosenbaum, CE, Ghoshal, NG and Hillman, D (eds) The Anatomy of the Domestic Animals, Vol. 1, 5th edn.Philadelphia, PA: Saunders, pp. 861915.Google Scholar
Harley, R, Gruffydd-Jones, T and Day, M (1998). Determination of salivary and serum immunoglobulin concentrations in the cat. Veterinary Immunology and Immunopathology 65: 99112.CrossRefGoogle ScholarPubMed
Heddle, R and Rowley, D (1975). Dog immunoglobulins. I. immunochemical characterization of dog serum, parotid saliva, colostrum, milk and small bowel fluid. Immunology 29: 185195.Google ScholarPubMed
Herath, HM (2003). Early diagnosis of typhoid fever by the detection of salivary IgA. Journal of Clinical Pathology 56: 694698.CrossRefGoogle ScholarPubMed
Hochman, N, Zakay-Rones, Z, Shohat, H, Ever-Hadani, P, Ehrlich, J, Schlesinger, M and Morag, A (1998). Antibodies to cytomegalo and Epstein–Barr viruses in human saliva and gingival fluid. The New Microbiologica 21: 131139.Google ScholarPubMed
Holtkamp, D, Rotto, H and Garcia, R (2007). The economic cost of major health challenges in large U.S. swine production systems. In: Proceedings of the 2007 American Association of Swine Veterinarians Annual Meeting, Orlando, Florida, pp. 8589.Google Scholar
Horner, M (1976). The passage of drugs into horse saliva and the suitability of saliva for pre-race testing. British Journal of Sports Medicine 10: 133140.CrossRefGoogle ScholarPubMed
Hurlimann, J and Darling, H (1971). In vitro synthesis of immunoglobulin-A by salivary glands from animals of different species. Immunology 21: 101111.Google ScholarPubMed
Kanter, F and Appleton, J (1940). Antibacterial effect of saliva on tubercle bacilli. Journal of Dental Research 19: 279280.Google Scholar
Kasempimolporn, S, Saengseesom, W, Lumlertdacha, B and Sitprija, V (2000). Detection of rabies virus antigen in dog saliva using a latex agglutination test. Journal of Clinical Microbiology 38: 30983099.CrossRefGoogle ScholarPubMed
Kinder, A, Carter, S, Allan, J, Marshall-Clarke, S and Craing, P (1992). Salivary and serum antibodies in experimental canine taeniasis. Veterinary Parasitology 41: 321327.CrossRefGoogle ScholarPubMed
Kraus, F and Konno, J (1963). Antibodies in saliva. Annals of the New York Academy of Sciences 106: 311329.CrossRefGoogle ScholarPubMed
Lewis, M, Wright, K, Lafrado, L, Shanker, P, Palumbo, N, Lemoine, E and Olsen, R (1987). Saliva as a source of feline leukemia virus antigen for diagnosis of disease. Journal of Clinical Microbiology 25: 13201322.CrossRefGoogle ScholarPubMed
Litt, DJ, Samuel, D, Duncan, J, Harnden, A, George, RC and Harrison, TG (2006). Detection of anti-pertussis toxin IgG in oral fluids for use in diagnosis and surveillance of Bordetella pertussis infection in children and young adults. Journal of Medical Microbiology 55: 12231228.CrossRefGoogle ScholarPubMed
Llena-Puy, C (2006). The role of saliva in maintaining oral health and as an aid to diagnosis. Medicina Oral, Patología Oral y Cirugía Bucal 11: E449455.Google ScholarPubMed
Loftager, M, Eriksen, L and Nielsen, R (1993). Antibodies against Actinobacillus pleuropneumoniae serotype 2 in mucosal secretions and sera of infected pigs as demonstrated by an enzyme-linked immunosorbent assay. Research in Veterinary Science 54: 5762.CrossRefGoogle ScholarPubMed
Lutz, H and Jarrett, O (1987). Detection of feline leukemia virus infection in saliva. Journal of Clinical Microbiology 25: 827831.CrossRefGoogle ScholarPubMed
Luzza, F, Maletta, M, Imeneo, M, Doldo, P, Marasco, R, Biancone, L and Pallone, F (1995). Salivary specific IgG is a sensitive indicator of the humoral immune response to Helicobacter pylori. FEMS Immunology and Medical Microbiology 10: 281283.CrossRefGoogle ScholarPubMed
Madonia, JV, Bahn, AN and Calandra, JC (1966). Salivary excretion of Coxsackie b-1 virus in rabbits. Applied Microbiology 14: 394396.CrossRefGoogle ScholarPubMed
Mandel, ID (1990). The diagnostic uses of saliva. Journal of Oral Pathology and Medicine 19: 119125.CrossRefGoogle ScholarPubMed
Mandel, ID (1993). Salivary diagnosis: promises, promises. Annals of the New York Academy of Sciences 694: 110.CrossRefGoogle ScholarPubMed
Martin, N (1969). The immunoglobulins: a review. Journal of Clinical Pathology 22: 117131.CrossRefGoogle ScholarPubMed
Mestecky, J (1987). The common mucosal immune system and current strategies for induction of immune responses in external secretions. Annals of the New York Academy of Sciences 7: 265276.Google ScholarPubMed
Mestecky, J (1993). Saliva as a manifestation of the common mucosal immune system. Annals of the New York Academy of Sciences 694: 184194.CrossRefGoogle ScholarPubMed
Michaels, P (1901). Saliva as an aid in the detection of diathetic diseases. Dental Digest 7: 105110.Google Scholar
Moe, CL, Sair, A, Lindesmith, L, Estes, MK and Jaykus, LA (2004). Diagnosis of Norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant Norwalk virus antigen. Clinical and Diagnostic Laboratory Immunology 11: 10281034.Google ScholarPubMed
Morgan, C and Gellhorn, A (1947). Detection of drugs in horse saliva. Analytical Chemistry 19: 806808.CrossRefGoogle Scholar
Morrier, J and Barsotti, O (1990). [Secretary IgA and the oral cavity: general review] <original> IgA sécrétoire et cavité buccale: revue générale. Actualités Odonto-Stomatologiques 44: 349364.Google Scholar
Moss, DM, Montgomery, JM, Newland, SV, Priest, JW and Lammie, PJ (2004). Detection of cryptosporidium antibodies in sera and oral fluids using multiplex bead assay. The Journal of Parasitology 90: 397404.CrossRefGoogle ScholarPubMed
Nair, P and Schroeder, H (1986). Duct associated lymphoid tissues (DALT) of minor salivary glands and mucosal immunity. Immunology 57: 171180.Google ScholarPubMed
Navazesh, M (1993). Methods for collecting saliva. Annals of the New York Academy of Sciences 694: 7277.CrossRefGoogle ScholarPubMed
Newcomb, RW, Ishizaka, K and DeVald, BL (1969). Human IgG and IgA diphtheria antitoxins in serum, nasal fluids and saliva. Journal of Immunology 103: 215224.CrossRefGoogle ScholarPubMed
Nigatu, D, Samuel, D, Cohen, B, Cumberland, P, Lemma, E, Brown, D and Nokes, J (2008). Evaluation of a measles vaccine campaign in Ethiopia using oral-fluid antibody surveys. Vaccine 26: 47694774.CrossRefGoogle ScholarPubMed
Nightingale, S (1995). From the food and drug administration: oral fluid specimen test system for HIV-1 approved. Journal of the American Medical Association 273: 613.CrossRefGoogle Scholar
Ohuma, E, Okiro, E, Bett, A, Abwao, J, Were, S, Samuel, D, Vyse, A, Gay, N, Brown, D and Nokes, D (2009). Evaluation of a measles vaccine campaign by oral-fluid surveys in a rural Kenyan district: interpretation of antibody prevalence data using mixture models. Epidemiology and Infection 137: 227233.CrossRefGoogle Scholar
Oliveira, S, Siqueira, M, Brown, D, Camacho, L, Faillace, T and Cohen, B (1998). Salivary diagnosis of measles for surveillance: a clinic-based study in Niterói, state of Rio de Janeiro, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 92: 636638.CrossRefGoogle ScholarPubMed
Parida, S, Anderson, J, Cox, S, Barnett, P and Paton, D (2006). Secretory IgA as an indicator of oro-pharyngeal foot-and-mouth disease virus replication and as a tool for post vaccination surveillance. Vaccine 24: 11071116.CrossRefGoogle ScholarPubMed
Petraityte, R, Jin, L, Hunjan, R, Razanskiene, A, Zvirbliene, A and Sasnauskas, K (2007). Use of Saccharomyces cerevisiae-expressed recombinant nucleocapsid protein to detect Hantaan virus-specific immunoglobulin G (IgG) and IgM in oral fluid. Clinical and Vaccine Immunology 14: 16031608.CrossRefGoogle ScholarPubMed
Pinho, RT, Pedrosa, RC, Costa-Martins, P and Castello-Branco, LR (1999). Saliva ELISA: a method for the diagnosis of chronic Chagas disease in endemic areas. Acta Tropica 72: 3138.CrossRefGoogle Scholar
Poli, A, Giannelli, C, Pistello, M, Zaccaro, L, Pieracci, D, Bendinelli, M and Malvaldi, G (1992). Detection of salivary antibodies in cats infected with feline immunodeficiency virus. Journal of Clinical Microbiology 30: 20382041.CrossRefGoogle ScholarPubMed
Pollaci, G and Ceraulo, S (1909). [The agglutinating properties of several body fluids during Malta fever] <original> Das agglutinationsvermögen einiger körperflüssigkeiten beim Mediterranfieber. Centralblatt für Bakteriologie, Parasitenkunde und Infektionskrankheiten (I). Abt Originale 52: 268275.Google Scholar
Prasad, SR, Yergolkar, PN, Walhekar, BD and Dandawate, CN (1994). Virus specific IgM, IgG and IgA antibodies in serum and saliva of Japanese encephalitis patients. Indian Journal of Pediatrics 61: 109110.CrossRefGoogle ScholarPubMed
Prickett, J, Cutler, S, Kinyon, J, Naberhaus, N, Stensland, W, Yoo, KJ and Zimmerman, JJ (2010). Stability of PRRSV diagnostic targets in swine oral fluid samples. Journal of Swine Health and Production (in press).Google Scholar
Prickett, J, Simer, R, Christopher-Hennings, J, Yoon, K-J, Evans, RB and Zimmerman, J (2008a). Detection of porcine reproductive and respiratory syndrome virus infection in porcine oral fluid samples: a longitudinal study under experimental conditions. Journal of Veterinary Diagnostic Investigation 20: 156163.CrossRefGoogle ScholarPubMed
Prickett, J, Simer, R, Yoon, K-J, Kim, W-I and Zimmerman, J (2008b). Surveillance of commercial growing pigs for PRRSV and PCV2 infections using pen-based oral fluid samples: A pilot study. Journal of Swine Health and Production 16: 8691.Google Scholar
Ramsay, M, Brugha, R and Brown, D (1997). Surveillance of measles in England and Wales: implications of a national saliva testing programme. Bulletin of the World Health Organization 75: 515521.Google ScholarPubMed
Renter, D, Visser, A, McFall, M, Smith, D, Berg, J, Silasi, L, Berezowski, J and Sorensen, O (2004). Rapid pen-level surveillance of E. coli O157:H7 in finished feedlot cattle. Animal Health Forum 9: 3.Google Scholar
Rothman, R and Kalish, B (2009). Update on emerging infections: news from the Centers for Disease Control and Prevention. False-positive oral fluid rapid HIV tests – New York City, 2005–2008. Annals of Emergency Medicine 53: 151156.Google ScholarPubMed
Schaefer, E (1990). AIDS testing trail approved for saliva test. Nature 346: 6287.CrossRefGoogle Scholar
Scicchitano, R, Sheldrake, RF and Husband, AJ (1986). Origin of immunoglobulins in respiratory tract secretion and saliva of sheep. Immunology 58: 315321.Google ScholarPubMed
Scott, DA, Coulter, WA and Larney, PJ (1997). Oral shedding of herpes simplex virus type 1: a review. Journal of Oral Pathology and Medicine 26: 441447.CrossRefGoogle ScholarPubMed
Shackleford, J and Wilborn, WH (1968). Structural and histochemical diversity in mammalian salivary glands. The Alabama Journal of Medical Sciences 5: 180203.Google ScholarPubMed
Sisson, S (1975a). Equine digestive system. In: Getty, R, Rosenbaum, CE, Ghoshal, NG and Hillman, D (eds) The Anatomy of the Domestic Animals, Vol. 1, 5th edn.Philadelphia, PA: Saunders, pp. 454497.Google Scholar
Sisson, S (1975b). Porcine digestive system. In: Getty, R, Rosenbaum, CE, Ghoshal, NG and Hillman, D (eds) The Anatomy of the Domestic Animals, Vol. 1, 5th edn.Philadelphia, PA: Saunders, pp. 12691282.Google Scholar
Smith, D, Gray, T, Moxley, R, Younts-dahl, S, Blackford, M, Hinkley, S, Hungerford, J, Milton, C and Klopfenstein, T (2004). A diagnostic strategy to determine the shiga toxin-producing Escherichia coli 0157 status of pens of feedlot cattle. Epidemiology and Infection 132: 297302.CrossRefGoogle Scholar
Smith, D, Moxley, R, Clowser, S, Folmer, J, Hinkley, S, Erickson, G and Klopfenstein, T (2005). Use of rope devices to describe and explain the feedlot ecology of Salmonella by time and place. Foodborne Pathogens and Disease 2: 6169.CrossRefGoogle ScholarPubMed
Smith, W, Dawson, A, Wells, P and Burrells, C (1975). Immunoglobulin concentrations in ovine body fluids. Research in Veterinary Science 19: 189194.CrossRefGoogle ScholarPubMed
South, M, Cooper, M, Wollheim, F, Hong, R and Good, R (1966). The IgA system. I. Studies of the transport and immunochemistry of IgA in the saliva. Journal of Experimental Medicine 123: 615627.CrossRefGoogle Scholar
Stallknecht, D, Howerth, E, Reeves, C and Seal, B (1999). Potential for contact and mechanical vector transmission of vesicular stomatitis virus New Jersey in pigs. American Journal of Veterinary Research 60: 4348.CrossRefGoogle ScholarPubMed
Stanford, K, Bach, S, Marx, T, Jones, S, Hansen, J, Wallins, G, Zahiroddini, H and McAllister, T (2005). Monitoring Escherichia coli O157:H7 in inoculated and naturally colonized feedlot cattle and their environment. Journal of Food Protection 68: 2633.CrossRefGoogle ScholarPubMed
Tabak, LA (2007). Point-of-care diagnostics enter the mouth. Annals of the New York Academy of Sciences 1098: 714.CrossRefGoogle ScholarPubMed
Tomasi, T and Zigelbaum, S (1963). The selective occurrence of gamma-1A globulins in certain body fluids. Journal of Clinical Investigation 42: 15521560.CrossRefGoogle Scholar
Waldman, RH, Mann, JJ and Kasel, JA (1968). Influenza virus neutralizing antibody in human respiratory secretions. Journal of Immunology 100: 8085.CrossRefGoogle ScholarPubMed
Wang, WK, Chen, SY, Liu, IJ, Chen, YC, Chen, HL, Yang, CF, Chen, PJ, Yeh, SH, Kao, CL, Huang, LM, Hsueh, PR, Wang, JT, Sheng, WH, Fang, CT, Hung, CC, Hsieh, SM, Su, CP, Chiang, WC, Yang, JY, Lin, JH, Hsieh, SC, Hu, HP, Chiang, YP, Wang, JT, Yang, PC and Chang, SC (2004). Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis. Emerging Infectious Diseases 10: 12131219.CrossRefGoogle ScholarPubMed
Ward, RL, Pax, KA, Sherwood, JR, Young, EC, Schiff, GM and Bernstein, DI (1992). Salivary antibody titers in adults challenged with a human rotavirus. Journal of Medical Virology 36: 222225.CrossRefGoogle ScholarPubMed
Wheatcroft, M (1957). A comparative study of human serum and salivary antibody titers in cases of Brucella melitensis infections. Journal of Dental Research 36: 112117.CrossRefGoogle ScholarPubMed
Wiggs, RB and Lobprise, HB (1997). Oral anatomy and physiology. In: Veterinary Dentristy, Principles and Practice. Philadelphia, PA: Lippincott-Raven Publishers, pp. 5586.Google Scholar
Willi, B, Boretti, FS, Baumgartner, C, Tasker, S, Wenger, B, Cattori, V, Meli, ML, Reusch, CE, Lutz, H and Hofmann-Lehmann, R (2006). Prevalence, risk factor analysis, and follow-up of infections caused by three feline hemoplasma species in cats in Switzerland. Journal of Clinical Microbiology 44: 961969.CrossRefGoogle ScholarPubMed
Yamamoto, J, Sparger, E, Ho, E, Andersen, P, O'Connor, T, Mandell, C, Lowenstine, L, Munn, R and Pedersen, N (1988). Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats. American Journal of Veterinary Research 49: 12461258.Google ScholarPubMed