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Classical swine fever in pigs: recent developments and future perspectives

Published online by Cambridge University Press:  13 June 2014

Vishal Chander ,
S. Nandi ,
C. Ravishankar ,
V. Upmanyu  and
Rishendra Verma
Vishal Chander*
Affiliation:
Virology Laboratory, Centre for Animal Disease Research and Diagnosis (CADRAD), Indian Veterinary Research Institute (IVRI), Izatnagar 243122, U.P., India
S. Nandi
Affiliation:
Virology Laboratory, Centre for Animal Disease Research and Diagnosis (CADRAD), Indian Veterinary Research Institute (IVRI), Izatnagar 243122, U.P., India
C. Ravishankar
Affiliation:
Virology Laboratory, Centre for Animal Disease Research and Diagnosis (CADRAD), Indian Veterinary Research Institute (IVRI), Izatnagar 243122, U.P., India
V. Upmanyu
Affiliation:
Division of Biological Standardization, IVRI, Izatnagar 243122, U.P., India
Rishendra Verma
Affiliation:
CADRAD, IVRI, Izatnagar 243122, U.P., India
*
*Corresponding author. E-mail: [email protected]
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Abstract

Classical swine fever (CSF) is one of the most devastating epizootic diseases of pigs, causing high morbidity and mortality worldwide. The diversity of clinical signs and similarity in disease manifestations to other diseases make CSF difficult to diagnose with certainty. The disease is further complicated by the presence of a number of different strains belonging to three phylogenetic groups. Advanced diagnostic techniques allow detection of antigens or antibodies in clinical samples, leading to implementation of proper and effective control programs. Polymerase chain reaction (PCR)-based methods, including portable real-time PCR, provide diagnosis in a few hours with precision and accuracy, even at the point of care. The disease is controlled by following a stamping out policy in countries where vaccination is not practiced, whereas immunization with live attenuated vaccines containing the ‘C’ strain is effectively used to control the disease in endemic countries. To overcome the problem of differentiation of infected from vaccinated animals, different types of marker vaccines, with variable degrees of efficacy, along with companion diagnostic assays have been developed and may be useful in controlling and even eradicating the disease in the foreseeable future. The present review aims to provide an overview and status of CSF as a whole with special reference to swine husbandry in India.

Keywords

classical swine feverPestivirusdiagnosisvaccinescontrol
Type
Review Article
Information
Animal Health Research Reviews , Volume 15 , Issue 1 , June 2014 , pp. 87 - 101
Copyright
Copyright © Cambridge University Press 2014 

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References

Afshar, AI, Dulac, GC and Bouffard, A (1989). Application of peroxidise labelled antibody assay for detection of porcine IgG antibodies to hog cholera and bovine diarrhoeal viruses. Journal of Virological Methods 23: 253–262.CrossRefGoogle Scholar
Ahrens, U, Kaden, V, Drexler, C and Visser, N (2000). Efficacy of the classical swine fever marker vaccine Porcilis Pesti in pregnant sows. Veterinary Microbiology 77: 83–97.Google Scholar
Andrew, ME, Morrissy, CJ, Lenghaus, C, Oke, PG, Sproat, KW, Hodgson, AL, Johnson, MA and Coupar, BE (2000). Protection of pigs against classical swine fever with DNA-delivered gp55. Vaccine 18: 1932–1938.Google Scholar
Andrew, M, Morris, K, Coupar, B, Sproat, K, Oke, P, Bruce, M, Broadway, M, Morrissy, C and Storm, D (2006). Porcine interleukin-3 enhances DNA vaccination against classical swine fever. Vaccine 24: 3241–3247.Google Scholar
Barman, NN, Gupt, RS, Bora, DP, Kataria, RS, Tiwari, AK and Roychoudhury, P (2010). Characterization of Classical swine fever virus involved in the outbreak in Mizoram. Indian Journal of Virology 21: 76–81.Google Scholar
Barman, NN, Bora, DP, Tiwari, AK, Kataria, RS, Desai, GS and Deka, PJ (2012). Classical swine fever in the pygmy hog. Revue Scientifique et Technique (International Office of Epizootics) 31: 919–930.Google Scholar
Beer, M, Reimann, I, Hoffmann, B and Depner, K (2007). Novel marker vaccines against classical swine fever. Vaccine 25: 5665–5670.Google Scholar
Bett, B, Deka, R, Padmakumar, V and Rajasekhar, M (2012). Classical swine fever in northeast India: prevention and control measures. ILRI Policy Brief 1–4. Available oline at http://cgspace.cgiar.org/bitstream/handle/10568/21152/Policy_brief_7_print.pdf?sequence=9.Google Scholar
Biron, CA and Sen, GC (2001). Interferon and other cytokines. In: Knipe, DM, Howley, PM, Griffin, DE, Marti, MRoizman, B and Straus, SE (eds) Fields Virology, 4th edn. Philadelphia: Lippincott Williams and Wilkins, pp. 321–351.Google Scholar
Biront, P, Leunen, J and Vandeputte, J (1987). Inhibition of virus replication in the tonsils of pigs previously vaccinated with a Chinese strain vaccine and challenged oronasally with a virulent strain of classical swine fever virus. Veterinary Microbiology 14: 105–113.Google Scholar
Blome, S, Meindl-Böhmer, A, Loeffen, W, Thuer, B and Moennig, V (2006). Assessment of classical swine fever diagnostics and vaccine performance. Revue Scientifique et Technique (International Office of Epizootics) 25: 1025–1038.Google Scholar
Blome, S, Meindl-Böhmer, A, Nowak, G and Moennig, V (2013). Disseminated intravascular coagulation does not play a major role in the pathogenesis of classical swine fever. Veterinary Microbiology 162: 360–368.Google Scholar
Bouma, A, de Smit, AJ, de Kluijver, EP, Terpstra, C and Moormann, RJM (1999). Efficacy and stability of a subunit vaccine based on glycoprotein E2 of classical swine fever virus. Veterinary Microbiology 66: 101–114.CrossRefGoogle ScholarPubMed
Carbrey, EA (1989). Diagnostic procedures. In: Liess, B (ed.) Classical Swine Fever and Related Viral Infections. Boston: Nijhoff, pp. 94–114.Google Scholar
Chakraborty, S, Veeregoda, BMChandra Naik, BM, Rathnamma, D, Isloor, S, Venkatesha, MD, Leena, G, Veeresh, H and Patil, SS (2011). Molecular characterization and genogrouping of classical swine fever virus isolated from field outbreaks. Indian Journal of Animal Sciences 81: 803–806.Google Scholar
Cheng, CY, Wu, CW, Lin, GJ, Lee, WC, Chien, MS and Huang, C (2014). Enhancing expression of the classical swine fever virus glycoprotein E2in yeast and its application to a blocking ELISA. Journal of Biotechnology http://dx.doi.org/10.1016/j.jbiotec.2014.01.007.Google Scholar
Cheville, NF, Mengeling, WL and Zinober, MR (1970). Ultrastructural and immunofluorescent studies of glomerulonephritis in hog cholera. Laboratory Investigation 22: 458–467.Google Scholar
Clavijo, A, Zhou, EM, Vydelingum, S and Heckert, R (1998). Development and evaluation of a novel antigen capture assay for the detection of classical swine fever virus antigens. Veterinary Microbiology 60: 155–168.Google Scholar
Cole, CG, Henley, RR, Dale, CN, Mott, LO, Torrey, JP and Zinober, MR (1962). History of hog cholera research in the US Department of Agriculture 1884–1960. Agriculture Information Bulletin No. 241. Washington DC: USDA.Google Scholar
de Arce, HD, Perez, LJ, Frias, MT, Rosell, R, Tarradas, J, Nunez, JL and Ganges, L (2009). A multiplex RT-PCR assay for the rapid and differential diagnosis of classical swine fever and other pestivirus infections. Veterinary Microbiology 139: 245–252.Google Scholar
Desai, GS, Sharma, A, Kataria, RS, Barman, NN and Tiwari, AK (2010). 5′-UTR-based phylogenetic analysis of classical swine fever virus isolates from India. Acta Virologica 54: 79–82.Google Scholar
de Smit, AJ, Bouma, A, Terpstra, C and van Oirschot, JT (1999). Transmission of classical swine fever virus by artificial insemination. Veterinary Microbiology 67: 239–249.Google Scholar
de Smit, AJ (2000). Laboratory diagnosis, epizootiology, and efficacy of marker vaccines in classical swine fever: a review. Vet Q 22: 182–8.Google Scholar
de Smit, AJ, van Gennip, HG, Miedem, GK, van Rijn, PA, Terpstra, C and Moormann, RJ (2000). Recombinant classical swine fever (CSF) viruses derived from the Chinese vaccine strain (C-strain) of CSF virus retain their avirulent and immunogenic characteristics. Vaccine 18: 2351–2358.Google Scholar
de Smit, AJ, Bouma, A, de Kluijver, EP, Terpstra, C and Moormann, RJ (2001). Duration of the protection of an E2 subunit marker vaccine against classical swine fever after a single vaccination. Veterinary Microbiology 78: 307–317.Google Scholar
Doherty, PC, Allan, W and Eichelberger, M (1992). Roles of alpha, beta and gamma delta T cell subsets in viral immunity. Annual Reviews of Immunology 10: 123–151.Google Scholar
Donahue, BC, Petrowski, HM, Melkonian, K, Ward, GB, Mayr, GA and Metwally, S (2012). Analysis of clinical samples for early detection of classical swine fever during infection with low, moderate, and highly virulent strains in relation to the onset of clinical signs. Journal of Virological Methods 179: 108–115.Google Scholar
Dong, XN and Chen, YH (2006). Candidate peptide-vaccines induced immunity against CSFV and identified sequential neutralizing determinants in antigenic domain A of glycoprotein E2. Vaccine 24: 1906–1913.Google Scholar
Dong, XN, Qi, Y, Ying, J, Chen, X and Chen, YH (2006). Candidate peptide-vaccine induced potent protection against CSFV and identified a principal sequential neutralizing determinant on E2. Vaccine 24: 426–434.Google Scholar
Dunne, HW (1975). Hog cholera. In. Dunne, HW and Leman, AD (eds) Diseases of Swine, 4th edn. Ames, IA: Iowa State University Press, pp. 189–255.Google Scholar
Edwards, S and Sands, JJ (1990). Antigenic comparison of hog cholera virus isolates from Europe, America and Asia using monoclonal antibodies. Deutsche Tierartzliche Wochenschrift 97: 79–91.Google Scholar
Edwards, S, Moennig, V and Wensvoor, G (1991). The development of an international reference panel of monoclonal antibodies for the differentiation of hog cholera virus from other pestiviruses. Veterinary Microbiology 29: 101–108.Google Scholar
Everett, H, Crooke, H, Gurrala, R, Dwarka, R, Kim, J, Botha, B, Lubisi, A, Pardini, A, Gers, S, Vosloo, W and Drew, T (2011). Experimental infection of common warthogs (Phacochoerus africanus) and bushpigs (Potamochoerus larvatus) with classical swine fever virus. I: susceptibility and transmission. Transboundary and Emerging Diseases 58: 128–134.Google Scholar
Feliziani, F, Blome, S, Petrini, S, Giammarioli, M, Iscaro, C, Severi, G, Convito, L, Pietschmann, J, Beer, M and Mia, GMD (2014). First assessment of classical swine fever marker vaccine candidate CP7 E2alf for oral immunization of wild boar under field conditions. Vaccine http://dx.doi.org/10.1016/j.vaccine.2014.02.006.Google Scholar
Feng, L, Li, XQ, Li, XN, Li, J, Meng, XM, Zhang, HY, Liang, JJ, Li, H, Sun, SK, Cai, XB, Su, LJ, Yin, S, Li, YS and Luo, TR (2012). In vitro infection with classical swine fever virus inhibits the transcription of immune response genes. Virology Journal 9: 175. doi: 10.1186/1743-422X-9-175.Google Scholar
Floegel-Niesmann, G (2001). Classical swine fever (CSF) marker vaccine. Trial III. Evaluation of discriminatory ELISAs. Veterinary Microbiology 83: 121–136.Google Scholar
Frey, CF, Bauhofar, D, Ruggli, M, Summerfield, A, Hoffman, MA and Tratschin, JD (2006). Classical swine fever virus replicon particles lacking the Erns gene : a potential marker vaccine for intradermal applications. Veterinary Research 37: 655–670.Google Scholar
Ganges, L, Barrera, M, Nunez, JI, Blanco, I, Frias, MT, Rodriguez, F and Sobrino, F (2005). A DNA vaccine expressing the E2 protein of classical swine fever virus elicits T cell responses that can prime for rapid antibody production and confer total protection upon viral challenge. Vaccine 23: 3741–3752.Google Scholar
Gers, S, Vosloo, W, Drew, T, Lubisi, BA, Pardini, A and Williams, M (2011). Experimental infection of common warthogs (Phacochoerus africanus) and bushpigs (Potamochoerus larvatus) with classical swine fever virus II: A comparative Histopathological study. Transboundary and Emerging Diseases 58: 135–144.Google Scholar
Gómez-Villamandos, JC, Ruiz-Villamor, E, Bautista, MJ, Sánchez, CP, Sánchez-Cordón, PJ, Salguero, FJ and Jover, A (2001). Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever. Journal of Comparative Pathology 125: 98–109.Google Scholar
Greiser-Wilke, I, Dreier, S, Haas, L and Zimmermann, B (2006). Genetic typing of classical swine fever viruses – a review. Deutsche Tieraztliche Wochenschrift 113: 134–138.Google Scholar
Hahn, J, Park, SH, Song, JY, An, SH and Ahn, BY (2001). Construction of recombinant swinepox viruses and expression of the classical swine fever virus E2 protein. Journal of Virological Methods 93: 49–56.Google Scholar
Hammond, JF, McCoy, RJ, Jansen, ES, Morrissy, CJ, Hogson, ALM and Johnson, MA (2000). Vaccination with a single dose of a recombinant porcine adenovirus expressing the classical swine fever virus gp55 (E2) gene protects pigs against classical swine fever. Vaccine 18: 1040–1050.Google Scholar
Hammond, JM, Jansen, ES, Morrissy, CJ, Goff, WV, Muhan, GC, Williamson, MM, Lenghaus, C, Sproat, KW, Andrew, ME, Coupur, BE and Johnson, MA (2001a). A prime boost vaccination strategy using naked DNA followed by recombinant porcine adenovirus protects pigs from classical swine fever. Veterinary Microbiology 80: 101–119.CrossRefGoogle ScholarPubMed
Hammond, JM, Jansen, ES, Morrissy, CJ, Williamson, MM, Hodgson, AL and Johnson, MA (2001b). Oral and sub-cutaneous vaccination of commercial pigs with a recombinant porcine adenovirus expressing the classical classical swine fever virus gp55 gene. Archives of Virology 146: 1787–1793.Google Scholar
Hammond, JM, Jansen, ES, Morrissy, CJ, Hodgson, AL and Johnson, MA (2003). Protection of pigs against ‘in contact’ challenge with classical swine fever following oral or subcutaneous vaccination with a recombinant porcine adenovirus. Virus Research 97: 151–157.Google Scholar
Hammond, JM and Johnson, MA (2005). Porcine adenovirus as a delivery system for swine vaccines and immunotherapeutics. Veterinary Journal 169: 17–27.Google Scholar
Hernández, J, Garfias, Y, Nieto, A, Mercado, C, Montan~o, LF and Centeno, E (2001). Comparative evaluation of CD4+CD8+ and CD4+ CD8+ lymphocytes in the immune response to porcine rubulavirus. Veterinary Immunology and Immunopathology 79: 249–259.Google Scholar
Hoffmann, B, Beer, M, Schelp, C, Schirrmeier, H and Depner, K (2005). Validation of a real-time RT-PCR assay for sensitive and specific detection of classical swine fever. Journal of Virological Methods 130: 36–44.Google Scholar
Holinka, LG, Fernandez-Sainz, I, O'Donnell, V, Prarat, MV, Gladue, DP, Lu, Z, Risatti, GR and Borca, MV (2009). Development of a live attenuated antigenic marker classical swine fever vaccine. Virology 384: 106–113.Google Scholar
Hsu, WL, Chen, CL, Huang, SW, Wu, CC, Chen, IH, Nadar, M, Su, YP and Tsai, CH (2014). The Untranslated regions of classic swine fever virus RNA trigger apoptosis. PLoS ONE 9: e88863. doi: 10.1371/journal.pone.0088863.Google Scholar
Huang, YL, Pang, VF, Pan, CH, Chen, TH, Jong, MH, Huang, TS and Jeng, CR (2009). Development of a reverse transcription multiplex real-time PCR for the detection and genotyping of classical swine fever virus. Journal of Virological Methods 160: 111–118.Google Scholar
ICTV (2012). The International Committee on Taxonomy of Viruses. http://www.ictvonline.org/virusTaxonomy.asp.Google Scholar
Kaden, V, Lange, E, Fischer, U and Strebelow, G (2000). Oral immunization of wild boar against classical swine fever: evaluation of the first field study in Germany. Veterinary Microbiology 73: 239–252.Google Scholar
Katz, JB, Ridpath, JF and Bolin, SR (1993). Presumptive diagnostic differentiation of hog cholera virus from bovine viral diarrhoea and border disease viruses by using a cDNA nested-amplification approach. Journal of Clinical Microbiology 31: 565–568.Google Scholar
Konig, M, Lengsfeld, T, Pauly, T, Stark, R and Thiel, HJ (1995). Classical swine fever virus: independent induction of protective immunity by two structural glycoproteins. Journal of Virology 69: 6479–6486.Google Scholar
Kortekaas, J, Vloet, RP, Weerdmeester, K, Ketelaar, J, van Eijk, M and Loeffen, WL (2010). Rational design of a classical swine fever C-strain vaccine virus that enables the differentiation between infected and vaccinated animals. Journal of Virological Methods 163: 175–185.Google Scholar
Krishnamurty, D (1964). Paper presented at the 11th Conference on Animal Diseases, Madras.Google Scholar
Kumar, H, Mahajan, V, Sharma, S, Alka Singh, R, Arora, AK, Banga, HS, Verma, S, Kaur, K, Kaur, P, Meenakshi, K and Sandhu, KS (2007). Concurrent pasteurellosis and classical swine fever in Indian pigs. Journal of Swine Health Production 15: 279–283.Google Scholar
Langedijk, JP, Middel, WG, Meloen, RH, Kramps, JA and de Smit, JA (2001). Enzyme-linked immunosorbent assay using a virus type-specific peptide based on a subdomain of envelope protein Erns for serologic diagnosis of pestivirus infections in swine. Journal of Clinical Microbiology 39: 906–912.Google Scholar
Lee, WC, Wang, CS and Chien, MS (1999). Virus antigen expression and alterations in peripheral blood mononuclear cell subpopulations after classical swine fever virus infection. Veterinary Microbiology 67: 17–29.Google Scholar
Leforban, Y, Edwards, S, Ibata, G and Vannier, P (1990). A blocking ELISA to differentiate hog cholera virus antibodies in pig sera from those due to other pestiviruses. Annales de Recherches Veterinaires 21: 119–129.Google Scholar
Leifer, I, Hoeper, D, Blome, S, Beer, M and Ruggli, N (2011). Clustering of classical swine fever virus isolates by codon pair bias. BMC Research Notes 4: 521. doi: 10.1186/1756-0500-4-521.Google Scholar
Lorena, J, Barlic-Maganja, D, Lojkić, M, Madić, J, Grom, J, Cac, Z, Roić, B, Terzić, S, Lojkić, I, Polancec, D and Cajavec, S (2001). Classical swine fever virus (C strain) distribution in organ samples of inoculated piglets. Veterinary Microbiology 81: 1–8.Google Scholar
Lowings, P, Ibata, G, Needham, J and Paton, D (1996). Classical swine fever diversity and evolution. Journal of General Virology 77: 1311–1321.Google Scholar
Mcgoldrick, A, Lowings, JP, Ibata, G, Sands, JJ, Belak, S and Paton, DJ (1998). A novel approach to the detection of classical swine fever virus by RT-PCR with a fluorogenic probe (Taq Man). Journal of Virological Methods 72: 125–135.Google Scholar
Meyer, H, Liess, B, Frey, HR, Hermanns, W and Trautwien, G (1981). Experimental transplacental transmission of hog cholera virus in pigs. Zentrallblatt fur Veterinarmedizin B 28: 659–668.Google Scholar
Moennig, V and Greiser-Wilke, I (2008). Classical swine fever virus. Encyclopedia of Virology 1: 525–533.Google Scholar
Monso, M, Tarradas, J, de la Torre, BG, Sobrino, F, Ganges, L and Andreu, D (2010). Peptide vaccine candidates against classical swine fever virus: T cell and neutralizing antibody responses of dendrimers displaying E2 and NS2–3 epitopes. Journal of Peptide Science 17: 24–31.CrossRefGoogle ScholarPubMed
Moormann, V, Schagemann, G, Dahle, J, Greiser-Wilke, I and Leder, L (1990). Molecular cloning and nucleotide sequence of hog cholera virus strain Brescia and mapping of the genomic region encoding envelope protein E1. Virology 177: 184–198.Google Scholar
Mori, Y, Nagamine, K, Tomita, N and Notomi, T (2001). Detection of loop-mediated isothermal amplification re-action by turbidity derived from magnesium pyrophos-phate formation. Biochemical and Biophysical Research Communications 289: 150–154.Google Scholar
Moser, C, Ruggli, N, Tratschin, JD, Hofmann, MA (1996). Detection of antibodies against classical swine fever virus in swine sera by indirect ELISA using recombinant envelope glycoprotein E2. Veterinary Microbiology 51: 41–53.Google Scholar
Mulder, WA, Priem, J, Glazenburg, KL, Wagenaar, F, Gruys, E, Gielkens, AL, Pol, JM, Kimman, TG (1994). Virulence and pathogenesis of non-virulent and virulent strains of pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus. Journal of General Virology 75: 117–124.Google Scholar
Muller, A, Depner, KR and Liess, B (1996). Evaluation of gp 55 (E2) recombinant based ELISA for the detection of antibodies induced by classical swine fever virus. Deutsche Tieraztliche Wochenschrift 103: 451–453.Google Scholar
Nandi, S, Muthuchelvan, D, Ahuja, A, Bisht, S, Chander, V, Pandey, AB, Singh, RK (2011a). Prevalence of classical swine fever virus in India: A 6-year study (2004–2010). Transboundary and Emerging Diseases 58: 461–463.Google Scholar
Nandi, S, Kumar, M and Manohar, M (2011b). Detection of classical swine fever virus antigen in tissue samples by AGPT. Indian Veterinary Journal 88: 10–11.Google Scholar
Narita, M, Kawashima, K and Shimizu, M (1996). Viral antigen and B and T lymphocytes in lymphoid tissues of gnotobiotic piglets infected with hog cholera virus. Journal of Comparative Pathology 114: 257–263.Google Scholar
Narita, M, Kawashima, K, Kimura, K, Mikami, O, Shibahara, T, Yamada, S and Sakoda, Y (2000). Comparative immunohistopathology in pigs infected with highly virulent or less virulent strains of hog cholera virus. Veterinary Pathology 37: 402–408.Google Scholar
Drew, TW (2008). Classical Swine Fever (hog cholera). In: OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals (mammals, birds and bees), 6th edn. Paris, France: World Organisation for Animal Health. pp. 1092–1106.Google Scholar
OIE (2014). http://www.oie.int/animal-health-in-the-world/oie-listed-diseases-2014/Google Scholar
Patil, SS, Hemadri, D, Shankar, BP, Raghavendra, AG, Veeresh, H, Sindhoora, B, Chandan, S, Sreekala, K, Gajendragad, MR and Prabhudas, K (2010). Genetic typing of recent classical swine fever isolates from India. Veterinary Microbiology 141: 367–373.Google Scholar
Patil, SS, Hemadri, D, Veeresh, H, Sreekala, K, Gajendragad, MR and Prabhudas, K (2012). Phylogenetic analysis of NS5B gene of classical swine fever virus isolates indicated plausible Chinese origin of Indian subgroup 2.2 viruses. Virus Gene 44: 104–108.Google Scholar
Paton, DJ (1995). Pestivirus diversity. Journal of Comparative Pathology 112: 215–236.Google Scholar
Paton, DJ, Mcgoldrick, A, Greiser-Wilke, I, Parchariyanon, S, Song, JY, Liou, PP, Stadejek, T, Lowings, JP, Bjorklund, H, Belak, S (2000a). Genetic typing of classical swine fever virus. Veterinary Microbiology 73: 137–157.Google Scholar
Paton, DJ, Mcgoldrick, A, Bensaude, E, Belak, S, Mittelholzer, C, Koenen, F, Vanderhallen, H, Greiser-Wilke, I, Scheibner, H, Stadejek, T, Hofmann, M and Thuer, B (2000b). Classical swine fever virus: a second ring test to evaluate RT-PCR detection methods. Veterinary Microbiology 77: 71–81.Google Scholar
Pauly, T, Elbers, K, König, M, Lengsfeld, T, Saalmüller, A and Thiel, HJ (1995). Classical swine fever virus-specific cytotoxic T lymphocytes and identification of a T cell epitope. Journal of General Virology 76: 3039–3049.Google Scholar
Pauly, T, Konig, M, Thiel, HJ and Saalmuller, A (1998). Infection with classical swine fever virus: effects on phenotype and immune responsiveness of porcine T lymphocytes. Journal of General Virology 79: 31–40.Google Scholar
Peeters, B, Bienkowska-Szewczyk, K, Hulst, M, Gielkens, A and Kimman, T (1997). Biologically safe, non-transmissible pseudorabies virus vector vaccine protects pigs against both Aujeszky's disease and classical swine fever. Journal of General Virology 78: 3311–3315.Google Scholar
Porntrakulpipat, S, Depner, KR and Moennig, V (1998). Detection of classical swine fever virus in peripheral blood leukocytes by flow cytometry. In: Proceedings of the OIE Symposium on Classical Swine Fever (Hog Cholera), Birmingham, U.K. p 44.Google Scholar
Radostitis, OM, Gay, CC, Hinchcliff, KW and Constable, PD (2007). Veterinary Medicine. 10th edn. USA: Saunders.Google Scholar
Rajkhowa, TK, Hauhnar, L and Jamlianthang, J (2013). Clinico- pathology and diagnosis of CSF in Zovawk pigs: an indigenus pig of Mizoram, India. Indian Journal of Animal Sciences 83: 620–624.Google Scholar
Rasmussen, TB, Reimann, I, Uttenthal, A, Leifer, I, Depner, K, Schirrmeier, H and Beer, M (2010). Generation of recombinant pestiviruses using a full-genome amplification strategy. Veterinary Microbiology 142: 13–17.Google Scholar
Reimann, I, Depner, K, Trapp, S and Beer, M (2004). An avirulent chimeric pestivirus with altered cell tropism protects pigs against lethal infection with classical swine fever virus. Virology 322: 143–157.Google Scholar
Renson, P, Le Dimna, M, Gabriel, C, Levai, R, Blome, S, Kulcsar, G, Koenen, F and Le Potier, MF (2014). Cytokine and immunoglobulin isotype profiles during CP7_E2alf vaccination against a challenge with the highly virulent Koslov strain of classical swine fever virus. Research in Veterinary Science http://dx.doi.org/10.1016/j.rvsc.2014.01.002.Google Scholar
Risatti, GR, Callahan, JD, Nelson, WM and Borca, MV (2003). Rapid detection of classical swine fever virus by a portable real-time reverse transcriptase PCR assay. Journal of Clinical Microbiology 41: 500–505.Google Scholar
Risatti, G, Holink, L, Lu, Z, Kutish, G, Callahan, JD, Nelson, WM, Brea Tio, E and Borca, MV (2005). Diagnostic evaluation of a real-time reverse transcriptase PCR assay for detection of classical swine fever virus. Journal of Clinical Microbiology 43: 468–471.Google Scholar
Rosen, TV, Rangelova, D, Nielsen, J, Rasmussen, TB, and Uttenthal, A (2014). DIVA vaccine properties of the live chimeric pestivirus strain CP7_E2gif. Veterinary Microbiology http://dx.doi.org/doi:10.1016/j.vetmic.2014.02.018.Google Scholar
Rümenapf, T, Stark, R, Meyers, G and Thiel, HJ (1991). Structural proteins of hog cholera virus expressed by vaccinia virus: further characterization and induction of protective immunity. Journal of Virology 65: 589–597.Google Scholar
Sánchez-Cordón, PJ, Romanini, S, Salguero, FJ, Nún~ez, A, Bautista, MJ, Jover, A and Gómez-Villamandos, JC (2002). Apoptosis of thymocytes related to cytokine expression in experimental classical swine fever. Journal of Comparative Pathology 127: 239–248.Google Scholar
Sánchez-Cordón, PJ, Romanini, S, Salguero, FJ, RuizVillamor, E, Carrasco, L, Gómez-Villamandos, JC (2003). A histopathological, immunohistochemical and ultrastructural study of the intestine in pigs inoculated with classical swine fever virus. Veterinary Pathology 40: 254–262.Google Scholar
Sánchez-Cordón, , Salguero, FJ, Carrasco, L and Gómez-Villamandos, JC (2005). Evolution of T lymphocytes and cytokine expression in classical swine fever (CSF) virus infection. Journal of Comparative Pathology 132: 249–260.Google Scholar
Sapre, SN, Moghe, RG, Bhagwat, SV, Chaudhry, PG and Purohit, BL (1962). A note on observations and investigations into an outbreak of swine fever in Bombay (Maharashtra). Indian Veterinary Journal 39: 527–534.Google Scholar
Sarma, DK, Krishna, L and Mishri, J (2008). Classical swine fever in pigs and its status in India: a review. Indian Journal of Animal Sciences 78: 1311–1317.Google Scholar
Sarma, DK, Mishra, N, Vilcek, S, Rajukumar, K, Behera, SP, Nema, RK, Dubey, P and Dubey, SC (2011). Phylogenetic analysis of recent classical swine fever virus (CSFV) isolates from Assam. Comparative Immunolology, Microbiolgy and Infectious Diseases 34: 11–15.Google Scholar
Shimizu, T, Kumagai, T, Ikeda, S and Matumoto, M (1964). A new in vitro method (END) for detection and measurement of hog cholera virus and its antibody by means of effect of HC virus on Newcastle disease virus in swine tissue culture. III.END neutralization test. Archives Gesammte Virusforsch 14: 215–226.Google Scholar
Shivaraj, DB, Patil, SS, Rathnammal, D, Hemadri, D, Geetha, S, Narayanaswamy, HD, Manjunatha Reddy, GB, Sharada, R, Aralikatti, SS and Rahman, H (2013). Early detection of classical swine fever virus in blood samples of pigs in Karnataka. Indian Journal of Comparative Microbiology, Immunology and Infectious Diseases 34: 18–23.Google Scholar
Summerfield, A, Rziha, HJ and Saalmüller, A (1996). Functional characterization of porcine CD4+ CD8+extrathymic T lymphocytes. Cellular Immunology 168: 291–296.Google Scholar
Summerfield, A, Knotig, SM and McCullough, KC (1998a). Lymphocyte apoptosis during classical swine fever: implication of activation induced cell death. Journal of Virology 72: 1853–1861.Google Scholar
Summerfield, AHofmann, MA and McCullough, KC (1998b). Low density blood granulocytic cells induced during classical swine fever are targets for virus infection. Veterinary Immunology and Immunopathology 63: 289–301.Google Scholar
Summerfield, A, Knotig, SM, Tschudin, R and McCullough, KC (2000). Pathogenesis of granulocytopenia and bone marrow atrophy during classical swine fever involves apoptosis and necrosis of uninfected cells. Virology 272: 50–60.Google Scholar
Summerfield, A, Zingle, K, Inumaru, S and McCullough, KC (2001). Induction of apoptosis in bone marrow neutrophil-lineage cells by classical swine fever virus. Journal of General Virology 82: 1309–1318.Google Scholar
Sun, Jin-fu, Shi, Zi-xue, Guo, Huan-cheng, Li, Su and Tu, Chang-chun (2011). Proteomic analysis of swine serum following highly virulent classical swine fever virus infection. Virology Journal 8: 107. doi: 10.1186/1743-422X-8-107.Google Scholar
Sun, Y, Li, N, Li, HY, Li, M and Qiu, HJ (2010). Enhanced immunity against classical swine fever in pigs induced by prime-boost immunization using an alphavirus replicon-vectored DNA vaccine and a recombinant adenovirus. Veterinary Immunology and Immunopathology 137: 20–27.Google Scholar
Sun, Y, Li, HY, Tian, DY, Han, QY, Zhang, X, Li, N and Qiu, HJ (2011). A novel alphavirus replicon-vectored vaccine delivered by adenovirus induces sterile immunity against classical swine fever. Vaccine 29: 8364–8372.Google Scholar
Suradhat, S, Intrakamhaeng, M and Damrongwatanapokin, S (2001). The correlation of virus-specific interferon-gamma production and protection against classical swine fever virus infection. Veterinary Immunology and Immunopathology 83: 177–189.Google Scholar
Susa, M, Konig, M, Saalmuller, A, Reddehase, MJ and Thiel, HJ (1992). Pathogenesis of classical swine fever: B-lymphocyte deficiency caused by hog cholera virus. Journal of Virology 66: 1171–1175.Google Scholar
Tizard, IR (1998). Células T auxiliaries y su respuesta al antígeno. In: Tizard, IR (ed.) Inmunología Veterinaria. 5th edn.Mexico: McGraw-Hill Interamericana Editores, pp. 119–131.Google Scholar
Uttenthal, A, Storgaard, T, Oleksiewicz, MB and de Stricker, K (2003). Experimental infection with the Paderborn isolate of classical swine fever virus in 10-week-old pigs: determination of viral replication kinetics by quantitative RT-PCR, virus isolation and antigen ELISA. Veterinary Microbiology 92: 197–212.Google Scholar
van Gennip, HG, van Rijn, PA, Widjojoatmodjo, MN, de Smit, AJ and Moormann, RJ (2000). Chimeric classical swine fever viruses containing envelope protein E (RNS) or E2 of bovine viral diarrhoea virus protect pigs against challenge with CSFV and induce a distinguishable antibody response. Vaccine 19: 447–459.Google Scholar
van Gennip, HG, Bouma, A, van Rijn, PA, Widjojoatmodjo, MN and Moormann, RJ (2002). Experimental non-transmissible marker vaccines for CSF by trans-complementation of Erns or E2 of CSFV. Vaccine 20 (11–12): 1544–1556.Google Scholar
van Iddekinge, HBJ, de Wind, N, Wensvoort, G, Kimman, TG, Giel kens, AL and Moormann, RJ (1996). Comparison of the protective efficacy of recombinant pseudorabies viruses against pseudorabies and classical swine fever in pigs; influence of different promoters on gene expression and on protection. Vaccine 14: 6–12.Google Scholar
van Oirschot, JT (1979). Experimental production of congenital persistent swine fever infections. I. Clinical, pathological and virological observations. Veterinary Microbiology 4: 117–132.Google Scholar
van Oirschot, JT (2000). Hog cholera. Infectious Diseases of Livestock 0: 975–986.Google Scholar
van Oirschot, JT (2003). Vaccinology of classical swine fever: from lab to field. Veterinary Microbiology 96: 367–384.Google Scholar
van Oirschot, JT (2004). Hog cholera. In: Coetzer, JAW and Tustin, RC (eds) Infectious Diseases of Livestock, 2nd edn. South Africa: Oxford University Press. pp. 975–986.Google Scholar
van Rijn, PA, Miedema, GK, Wensvoort, G, van Gennip, HGP, Moormann, RJM (1994). Antigenic structure of envelope glycoprotein E1 of hog cholera virus. Journal of Virology 68: 3934–3942.Google Scholar
van Rijn, PA, Bossers, A, Wensvoort, G and Moormann, RJM (1996). Classical swine fever virus (CSFV) envelope glycoprotein E2 containing one structural antigenic unit protects pigs from lethal CSFV challenge. Journal of General Virology 77: 2737–2745.Google Scholar
van Rijn, PA, van Gennip, HGP, Leendertse, CH, Bruschke, CJM, Paton, DJ, Moormann, RJM and Van Oirschot, JT (1997). Subdivision of the pestivirus genes based on envelope glycoprotein E2. Virology 237: 337–348.CrossRefGoogle ScholarPubMed
Van Snick, J (1990). Interleukin-6: an overview. Annual Reviews of Immunology 8: 253–278.Google Scholar
van Zijl, M, Wensvoort, G, de Kluyver, E, Hulst, M, van der Gulden, H, Gielkens, A and Moormann, R (1991). Live attenuated pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus protects swine against both pseudorabies and hog cholera. Journal of Virology 65: 2761–2765.CrossRefGoogle ScholarPubMed
Vannier, P, Plateau, E and Tillon, JP (1981). Congenital tremor in pigs farrowed from sows given hog cholera virus during pregnancy. American Journal of Veterinary Research 42: 135–137.Google Scholar
Vilcek, S, Herring, AJ, Nettleton, PF, Lowings, JP and Paton, DJ (1994). Pestiviruses isolated from pigs, cattle and sheep can be allocated into at least three genogroups using polymerase chain reaction and restriction endonuclease analysis. Archives of Virology 136: 309–323.Google Scholar
Vilcek, S, Stadejek, T, Ballagi-Pordany, A, Lowings, JP, Paton, DJ and Belak, S (1996). Genetic variability of classical swine fever virus. Virus Research 43: 137–147.Google Scholar
Voigt, H (2005). Rekombinante Parapockenvakzine gegen klassische Schweinepest: Vergleichende Charakterisierung der Immunreaktionen im Schwein. Inaugural-Dissertation LMU M¨unchen.Google Scholar
Weesendorp, E, Willems, EM and Loeffen, WLA (2010). The effect of tissue degradation on detection of infectious virus and viral RNA to diagnose classical swine fever virus. Veterinary Microbiology 141: 275–281.Google Scholar
Wensvoort, G, Terpstra, C and De Kluyver, EP (1989). Characterization of porcine and some ruminant pestiviruses by cross-neutralisation. Veterinary Microbiology 20: 291–306.Google Scholar
Wienhold, D, Armengol, E, Marquardt, A, Marquardt, C, Voigt, H, Buttner, M, Saalmuller, A and Pfaff, E (2005). Immunomodulatory effect of plasmids co-expressing cytokines in classical swine fever virus subunit gp55/E2-DNA vaccination. Veterinary Research 36: 571–587.Google Scholar
Wongsawat, K, Dharakul, T, Narat, P and Rabablert, P (2011). Detection of nucleic acid of classical swine fever virus by reverse transcription loop-mediated isothermal amplification (RT-LAMP). Health 3: 447–452.Google Scholar
Yu, X, Tu, C, Li, H, Hu, R, Chen, C, Li, Z, Zhang, M and Yin, Z (2001). DNA-mediated protection against classical swine fever virus. Vaccine 19: 1520–1525.Google Scholar
Zhao, HP, Sun, JY, Sun, Y, Li, N and Qiu, HJ (2009). Prime-boost immunization using alphavirus replicon and adenovirus vectored vaccines induces enhanced immune responses against classical swine fever virus in mice. Veterinary Immunology and Immunopathology 131: 158–166.Google Scholar
Zhou, B, Liu, K, Jiang, Y, Jian-Chao Wei, JC and Chen, PU (2011). Multiple linear B-cell epitopes of classical swine fever virus glycoprotein E2 expressed in E. coli as multiple epitope vaccine induces a protective immune response. Journal of Virology 8: 378. doi: 10.1186/1743–422X-8-378.Google Scholar