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Bovine respiratory disease research (1983–2009)

Published online by Cambridge University Press:  15 December 2009

Robert W. Fulton
Robert W. Fulton*
Affiliation:
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
*
E-mail: [email protected]
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Abstract

Bovine respiratory disease (BRD) research has provided significant understanding of the disease over the past 26 years. Modern research tools that have been used include monoclonal antibodies, genomics, polymerase chain reaction, immunohistochemistry (IHC), DNA vaccines and viral vectors coding for immunogens. Emerging/reemerging viruses and new antigenic strains of viruses and bacteria have been identified. Methods of detection and the role for cattle persistently infected bovine viral diarrhea virus (BVDV) were identified; viral subunits, cellular components and bacterial products have been characterized. Product advances have included vaccines for bovine respiratory syncytial virus, Mannheimia haemolytica and Pasteurella multocida; the addition of BVDV2 to the existing vaccines and new antibiotics. The role of Mycoplasma spp., particularly Mycoplasma bovis in BRD, has been more extensively studied. Bovine immunology research has provided more specific information on immune responses, T cell subsets and cytokines. The molecular and genetic basis for viral–bacterial synergy in BRD has been described. Attempts have been made to document how prevention of BRD by proper vaccination and management prior to exposure to infectious agents can minimize disease and serve as economic incentives for certified health programs.

Keywords

infectious agentspreventioncontrolvaccinesbovine respiratory diseasecattleshipping feverimmunity
Type
Review Article
Information
Animal Health Research Reviews , Volume 10 , Issue 2 , December 2009 , pp. 131 - 139
Copyright
Copyright © Cambridge University Press 2009

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References

Babiuk, LA, van Drunen Little-van den Hurk, S and Tikoo, SK (1996). Immunology of bovine herpesvirus-1 infection. Veterinary Microbiology 53: 31–42.Google Scholar
Booker, CW, Abutarbush, SM, Morley, PS, Jim, GK, Pitman, TJ, Schunicht, OC, Perret, T, Wildman, BK, Fenton, RK, Guichon, PT and Janzen, ED (2008). Microbiological and histopathological findings in cases of feedlot cattle in western Canada. Canadian Veterinary Journal 49: 473–481.Google ScholarPubMed
Bryant, TC, Rogers, KC, Stone, ND and Miles, DG (2008). Effect of viral respiratory vaccine treatment on performance, health and carcass traits of auction-origin feeder steers. Bovine Practitioner 42: 98–103.Google Scholar
Carman, S, van Dreumel, T, Ridpath, J, Hazlett, M, Alves, D, Dubovi, E, Tremblay, R, Bolin, S, Godkin, A and Anderson, (1998). Severe acute bovine viral diarrhea in Ontario, 1992–1995. Journal of Veterinary Diagnostic Investigation 10: 27–35.Google Scholar
Caswell, JL and Archambault, M (2007). Mycoplasma bovis pneumonia in cattle. Animal Health Research Reviews 8: 161–186.CrossRefGoogle ScholarPubMed
Compendium of Veterinary Products (2008). 11th edition. Port Huron, MI: North American Compendium Ltd, p. 1–2428.Google Scholar
Corbeil, LB (2007). Histophilus somni host-parasite relationships. Animal Health Research Reviews 8: 151–160.CrossRefGoogle ScholarPubMed
Dabo, SM, Taylor, JD and Confer, AW (2007). Pasteurella multocida and bovine respiratory disease. Animal Health Research Reviews 8: 129–150.Google Scholar
de Almeida, DE, Colvine, CJ and Coussens, PM (2008). Antigen-specific regulatory T cells in bovine paratuberculosis. Veterinary Immunology and Immunopathology 125: 234–245.CrossRefGoogle ScholarPubMed
Ellis, JA (2001). The immunology of the bovine respiratory disease complex. Veterinary Clinics of North America, Food Animal Practice 17: 535–550.Google Scholar
Ellis, JA, Waldner, C, Rhodes, C and Ricketts, V (2005). Longevity of protective immunity to experimental bovine herpesvirus-1 infection following inoculation with a combination modified-live virus vaccine in beef calves. Journal of the American Veterinary Medical Association 227: 123–128.CrossRefGoogle ScholarPubMed
Esser, MT, Marchese, RD, Kierstead, LS, Tussey, LG, Wang, F, Chirmule, N and Washabaugh, MW (2003). Memory T cells and vaccines. Vaccine 21: 419–430.Google Scholar
Fulton, RW, Purdy, CW, Confer, AW, Saliki, JT, Loan, RW, Briggs, RE and Burge, LJ (2000). Bovine viral diarrhea viral infections in feeder calves with respiratory disease: interactions with Pasteurella spp. parainfluenza-3 virus, and respiratory syncytial virus. Journal for Veterinary Research 64: 151–159.Google ScholarPubMed
Fulton, RW, Cook, BJ, Step, DL, Confer, AW, Saliki, JT, Burge, LJ, Welsh, RD, Blood, KS and Payton, M (2002a). Evaluation of health states of calves and the impact of feedlot performance: assessment of retained ownership program for postweaning calves. Canadian Journal of Veterinary Research 66: 173–180.Google ScholarPubMed
Fulton, RW, Ridpath, JF, Saliki, JT, Briggs, RE, Confer, AW, Burge, LJ, Purdy, CW, Loan, RW, Duff, GC and Payton, ME (2002b). Bovine viral diarrhea virus (BVDV1b: predominant BVDV subtype in calves with respiratory disease. Canadian Journal of Veterinary Research 66: 181–190.Google Scholar
Fulton, RW, Blood, KS, Panciera, RJ, Payton, ME, Ridpath, JF, Confer, AW, Saliki, JT, Burge, LJ, Welsh, RD, Johnson, BJ and Reck, A (2009). Lung pathology and infectious agents in fatal feedlot pneumonias and relationship with mortality, disease onset, and treatments. Journal of Veterinary Diagnostic Investigation 21 (4): 464–477.Google Scholar
Gagea, MI, Bateman, KG, Shanahan, RA, van Dreumel, T, McEwen, BJ, Carman, S, Archambault, M and Caswell, JL (2006a). Naturally occurring Mycoplasma bovis – associated pneumonia and polyarthritis in feedlot beef calves. Journal of Veterinary Diagnostic Investigation 18: 29–40.Google Scholar
Gagea, MI, Bateman, KG, van Dreumel, T, McEwen, BJ, Carman, S, Archambault, M, Shanahan, M, Shanahan, RA and Caswell, JL (2006b). Diseases and pathogens associated with mortality in Ontario beef feedlots. Journal of Veterinary Diagnostic Investigation 18: 18–28.Google Scholar
Gershwin, LJ (2007). Bovine respiratory syncytial virus infection: immunopathogenic mechanisms. Animal Health Research Reviews 8: 207–213.CrossRefGoogle ScholarPubMed
Griffin, D (1997). Economic impact associated with respiratory disease in beef cattle. Veterinary Clinics of North America, Food Animal Practice 13: 367–377.Google Scholar
Haines, DM, Martin, KM, Clark, EG, Jim, GK and Janzen, ED (2001). The immunohistochemical detection of Mycoplasma bovis and bovine viral diarrhea virus in tissues of feedlot cattle with chronic, unresponsive respiratory disease and/or arthritis. Canadian Veterinary Journal 42: 857–860.Google Scholar
Hodgson, PD, Aich, A, Manuja, A, Hokamp, H, Roche, FM, Brinkman, FSL, Potter, A, Babiuk, LA and Griebel, PJ (2005). Effect of stress on viral–bacterial synergy in bovine respiratory disease: novel mechanisms to regulate inflammation. Comparative and Functional Genomics 6: 244–250.CrossRefGoogle ScholarPubMed
Irsik, M, Langemeier, M, Schroeder, T, Spire, M and Roder, JD (2006). Estimating the effects of animal health on the performance of feedlot cattle. Bovine Practitioner 40: 65–74.Google Scholar
Jensen, R, Pierson, RE, Braddy, PM, Saari, DA, Lauerman, LH, England, JJ, Keyvanfar, H, Collier, JR, Horton, DP, McChesney, AE, Benitez, A and Christie, RM (1976a). Diseases of yearling feedlot cattle in Colorado. Journal of the American Veterinary Medical Association 169: 497–499.Google Scholar
Jensen, R, Pierson, RE, Braddy, PM, Saari, DA, Lauerman, LH, England, JJ, Keyvanfar, H, Collier, JR, Horton, DP, McChesney, AE, Benitez, A and Christie, RM (1976b). Shipping fever pneumonia in yearling feedlot cattle. Journal of the American Veterinary Medical Association 169: 500–506.Google ScholarPubMed
Jones, C and Chowdhury, S (2007). A review of the biology of bovine herpesvirus type (BHV-1), its role as co-factor in the bovine respiratory disease complex and development of improved vaccines. Animal Health Research Reviews 8: 187–205.CrossRefGoogle Scholar
King, ME, Salman, MD, Wittum, TE, Odde, KG, Seeger, JT, Grotelueschen, DM, Rogers, GM and Quakenbush, GA (2006). Effect of certified health programs on the sale price of beef calves marketed through a livestock videotape auction service from 1995 through 2005. Journal of American Veterinary Medical Association 229: 1389–1400.CrossRefGoogle Scholar
Loan, RW(ed.) (1984). Bovine Respiratory Disease: A Symposium. College Station, TX: Texas A&M University Press. pp. 1–520.Google Scholar
Loneragan, GH, Dargatz, DA, Morley, PS and Smith, M (2001). Trends in mortality ratios among cattle in US feedlots. Journal of American Veterinary Medical Association 219: 1122–1127.Google Scholar
Macartney, JE, Bateman, KG and Ribble, C (2003a). Comparison of prices paid for feeder calves sold at conventional auctions versus special auctions of vaccinated or conditioned calves in Ontario. Journal of the American Veterinary Medical Association 223: 670–676.CrossRefGoogle ScholarPubMed
Macartney, JE, Bateman, KG and Ribble, C (2003b). Health performance of feeder calves sold at conventional auctions versus special auctions of vaccinated or conditioned calves in Ontario. Journal of the American Veterinary Medical Association 223: 677–683.Google Scholar
MacGregor, S, Smith, D, Perino, LJ and Hunsaker, BD (2003). An evaluation of the effectiveness of a commercial Mannheimia (Pasteurella) haemolytica vaccine in a commercial feedlot. Bovine Practitioner 37: 78–82.Google Scholar
Martin, SW and Bohac, JG (1986). The association between serological titers in infectious bovine rhinotracheitis virus, bovine viral diarrhea virus, parainfluenza-3 virus, respiratory syncytial virus and treatment for respiratory disease in Ontariol feedlot calves. Canadian Journal of Veterinary Research 50: 351–358.Google ScholarPubMed
Maunsell, FP, Donovan, GA, Risco, C and Brown, MB (2009). Field evaluation of a Mycoplasma bovis bacterin in young dairy calves. Vaccine 27: 2781–2788.CrossRefGoogle ScholarPubMed
Muylkens, B, Thiry, J, Kirten, P, Schynts, F and Thiry, E (2007). Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis. Veterinary Research 38: 181–209.Google Scholar
Ohmann, HB and Babiuk, LA (1985). Viral-bacterial pneumonia in calves: effect of bovine herpesvirus-1 on immunologic functions. Journal of Infectious Diseases 151: 937–947.CrossRefGoogle Scholar
Ohmann, HB, Babiuk, BA and Harland, R (1991). Cytokine synergy with viral cytopathic effects and bacterial products during the pathogenesis of respiratory tract infections. Clinical Immunology and Immunopathology 60: 163–170.Google Scholar
Pfizer Inc. (2007). Bovine Respiratory Disease Handbook. 1st edn. p. 1–30.Google Scholar
Platt, R, Burdett, W and Roth, JA (2006). Induction of antigen-specific T-cell subset activation to bovine respiratory disease viruses by a modified-live vaccine. American Journal of Veterinary Research 67: 1179–1184.CrossRefGoogle Scholar
Rice, JA, Carrasco-Medina, L, Hodgins, DC and Shewen, PE (2007). Mannheimia haemolytica and bovine respiratory disease. Animal Health Research Reviews 8: 117–128.CrossRefGoogle ScholarPubMed
Ridpath, JF and Fulton, RW (2009). Knowledge gaps impacting the development of BVDV control programs in the United States. Journal of the American Veterinary Medical Association In press.Google Scholar
Ridpath, JF, Bolin, SR and Dubovi, EJ (1994). Segregation of bovine viral diarrhea virus in genotypes. Virology 205: 66–74.CrossRefGoogle ScholarPubMed
Robertson, SJ and Hasenkrug, KJ (2006). The role of virus-induced regulatory T cells in immunopathology. Springer Seminars of Immunology 28: 51–62.Google Scholar
Robinson, KE, Meers, J, Gravel, JL, McCarthy, FM and Mahony, TJ (2008). The essential and non-essential genes of bovine herpesvirus 1. Journal of General Virology 89: 2851–2863.Google Scholar
Seeger, JT, Grotelueschen, DM, Stokka, GL and Sides, GE (2008). Comparison of feedlot health, nutritional performance, carcass characteristics and economic value of the unweaned beef calves with an unknown health history and weaned beef calves receiving various herd-of-origin health protocols. Bovine Practitioner 42: 27–39.CrossRefGoogle Scholar
Smith, RA (2000). Effects of feedlot disease on economics, production and carcass value. The American Association of Bovine Practitioners Proceedings 33: 125–128.Google Scholar
Srikumaran, S, Kelling, CL and Ambagala, A (2007). Immune evasion by pathogens of bovine respiratory disease complex. Animal Health Research Reviews 8: 215–229.Google Scholar
Storz, J, Stine, L, Liem, A and Anderson, G (1996). Coronavirus isolation from nasal swab samples from cattle with signs of respiratory tract disease after shipping. Journal of the American Veterinary Medical Association 208: 1452–1455.Google Scholar
Tanaka, S, Aso, H, Miyazawa, K, Nagai, Y, Watanabe, K, Ohwada, S, Kobayashi, J and Yamaguchi, T (2007). Differential cytokine gene expression in CD4+ T cell subsets of calves. Veterinary Immunology and Immunopathology 118: 84–91.Google Scholar
The Bovine Map Consortium (2009). Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science 324: 528–534.Google Scholar
Thomas, CJ, Hoet, AE, Sreevatsan, S, Wittum, TE, Briggs, RE, Duff, GC and Saif, LJ (2006). Transmission of bovine coronavirus and serologic responses in feedlot calves under field conditions. American Journal of Veterinary Research 67: 1412–1420.Google Scholar
Valarcher, JF and Taylor, G (2007). Bovine respiratory syncytial virus infection. Veterinary Research 38: 153–180.Google Scholar
van Drunen, Little-van den, Hurk, Myers, D, Doig, PA, Karvonen, M, Habermehl, M, Babiuk, LA, Jelinski, M, Van Donkersgoed, J, Schlesinger, K and Rinehart, C (2001). Identification of a mutant bovine herpesvirus-1 (BHV-1) in post-arrival outbreaks of IBR in feedlot calves and protection against conventional vaccination. Canadian Journal of Veterinary Research 65: 81–88.Google Scholar
Veterinary Pharmaceuticals and Biologicals 1982/1983 (1983). Aronson CE (ed.).1/1-A/64. Vetinary Medicine Publishing Co.Google Scholar
Woodland, DL (2003). Cell-mediated immunity to respiratory virus infections. Current Opinion in Immunology 15: 430–435.CrossRefGoogle ScholarPubMed
Woolums, A, Loneragan, GH, Hawkins, LL and Williams, SM (2005). Baseline management practices and animal health data reported by US feedlots responding to a survey regarding acute interstitial pneumonia. Bovine Practitioner 39: 116–124.Google Scholar