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Up to new tricks – A review of cross-species transmission of influenza A viruses

Published online by Cambridge University Press:  13 August 2007

Gabriele A. Landolt  and
Christopher W. Olsen
Gabriele A. Landolt*
Affiliation:
Department of Clinical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA
Christopher W. Olsen
Affiliation:
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA
*
*Corresponding author. E-mail: [email protected]
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Abstract

Influenza is a highly contagious disease that has burdened both humans and animals since ancient times. In humans, the most dramatic consequences of influenza are associated with periodically occurring pandemics. Pandemics require the emergence of an antigenically novel virus to which the majority of the population lacks protective immunity. Historically, influenza A viruses from animals have contributed to the generation of human pandemic viruses and they may do so again in the future. It is, therefore, critical to understand the epidemiological and molecular mechanisms that allow influenza A viruses to cross species barriers. This review summarizes the current knowledge of influenza ecology, and the viral factors that are thought to determine influenza A virus species specificity.

Keywords

Influenza A viruscross-species transmissionecologyspecies-specificity
Type
Review Article
Information
Animal Health Research Reviews , Volume 8 , Issue 1 , June 2007 , pp. 1 - 21
Copyright
Copyright © Cambridge University Press 2007

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