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BVDV vaccination in North America: risks versus benefits

Published online by Cambridge University Press:  08 June 2015

Philip J. Griebel
Philip J. Griebel*
Affiliation:
VIDO/Intervac, 120-Veterinary Road, University of Saskatchewan, Saskatoon, SK S7N 5E3Canada School of Public Health, University of Saskatchewan, Saskatoon, SK S7N 5E3Canada
*
*Corresponding author. E-mail: [email protected]
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Abstract

The control and prevention of bovine viral diarrhea virus (BVDV) infections has provided substantial challenges. Viral genetic variation, persistent infections, and viral tropism for immune cells have complicated disease control strategies. Vaccination has, however, provided an effective tool to prevent acute systemic infections and increase reproductive efficiency through fetal protection. There has been substantial controversy about the safety and efficacy of BVDV vaccines, especially when comparing killed versus modified-live viral (MLV) vaccines. Furthermore, numerous vaccination protocols have been proposed to protect the fetus and ensure maternal antibody transfer to the calf. These issues have been further complicated by reports of immune suppression during natural infections and following vaccination. While killed BVDV vaccines provide the greatest safety, their limited immunogenicity makes multiple vaccinations necessary. In contrast, MLV BVDV vaccines induce a broader range of immune responses with a longer duration of immunity, but require strategic vaccination to minimize potential risks. Vaccination strategies for breeding females and young calves, in the face of maternal antibody, are discussed. With intranasal vaccination of young calves it is possible to avoid maternal antibody interference and induce immune memory that persists for 6–8 months. Thus, with an integrated vaccination protocol for both breeding cows and calves it is possible to maximize disease protection while minimizing vaccine risks.

Keywords

BVDVkilled vaccinemodified-live vaccinematernal antibodymucosal immunization
Type
Review Article
Information
Animal Health Research Reviews , Volume 16 , Issue 1 , June 2015 , pp. 27 - 32
Copyright
Copyright © Cambridge University Press 2015 

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References

Bolin, SR (1995). Control of bovine viral diarrhea infection by use of vaccination. Veterinary Clinics of North America Food Animal Practice 11: 615–625.CrossRefGoogle ScholarPubMed
Bolin, SR and Ridpath, JF (1996). Glycoprotein E2 of bovine viral diarrhea virus expressed in insect cells provides calves limited protection from systemic infection and disease. Archives of Virology 141: 1463–1477.CrossRefGoogle ScholarPubMed
Brownlie, J (1990). Pathogenesis of mucosal disease and molecular aspects of bovine virus diarrhoea virus. Veterinary Microbiology 23: 371–382.CrossRefGoogle ScholarPubMed
Chamorro, MF, Walz, PH, Haines, DM, Passler, T, Earleywine, T, Palomares, RA, Riddell, KP, Galik, P, Zhang, Y and Givens, MD (2014). Comparison of levels and duration of detection of antibodies to bovine viral diarrhea virus 1, bovine viral diarrhea virus 2, bovine respiratory syncytial virus, bovine herpesvirus 1, and bovine parainfluenza virus 3 in calves fed maternal colostrum or a colostrum-replacement product. Canadian Journal of Veterinary Research 78: 81–88.Google ScholarPubMed
Ciulli, S, Galletti, E, Battilani, M, Galligioni, V and Prosperi, S (2009). Analysis of variability and antigenic peptide prediction of E2 BVDV glycoprotein in a mucosal-disease affected animal. Veterinary Research Communications 33 (suppl. 1): 125–127.CrossRefGoogle Scholar
Coggins, L, Gillespie, JH, Robson, DS, Thompson, JD, Phillips, WV, Wagner, WC and Baker, JA (1961). Attenuation of virus diarrhea virus (strain Oregon C24 V) for vaccine purposes. Cornell Veterinarian 51: 539–545.Google Scholar
Endsley, JJ, Ridpath, JF, Neill, JD, Sandbulte, MR and Roth, JA (2004). Induction of T lymphocytes specific for bovine viral diarrhea virus in calves with maternal antibody. Viral Immunology 17: 13–23.Google Scholar
Endsley, JJ, Roth, JA, Ridpath, J and Neill, J (2003). Maternal antibody blocks humoral but not T cell responses to BVDV. Biologicals 31: 123–125. Review.CrossRefGoogle Scholar
Falkenberg, SM, Johnson, C, Bauermann, FV, McGill, J, Palmer, MV, Sacco, RE and Ridpath, JF (2014). Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves. Veterinary Immunology and Immunopathology 160: 70–80.CrossRefGoogle ScholarPubMed
Fulton, RW, d'Offay, JM, Eberle, R, Moeller, RB, Campen, HV, O'Toole, D, Chase, C, Miller, MM, Sprowls, R and Nydam, DV (2015). Bovine herpesvirus-1: evaluation of genetic diversity of subtypes derived from field strains of varied clinical syndromes and their relationship to vaccine strains. Vaccine 33: 549–558.CrossRefGoogle ScholarPubMed
Givens, MD, Marley, MS, Jones, CA, Ensley, DT, Galik, PK, Zhang, Y, Riddell, KP, Joiner, KS, Brodersen, BW and Rodning, SP (2012). Protective effects against abortion and fetal infection following exposure to bovine viral diarrhea virus and bovine herpesvirus 1 during pregnancy in beef heifers that received two doses of a multivalent modified-live virus vaccine prior to breeding. Journal of the American Veterinary Medical Association 241: 484–495.Google Scholar
Goens, SD (2002). The evolution of bovine viral diarrhea: a review. Canadian Veterinary Journal 43: 946–954.Google ScholarPubMed
González, AM, Arnaiz, I, Yus, E, Eiras, C, Sanjuán, M and Diéguez, FJ (2014). Evaluation of long-term antibody responses to two inactivated bovine viral diarrhoea virus (BVDV) vaccines. Veterinary Journal 199: 424–428.CrossRefGoogle ScholarPubMed
Hill, KL, Hunsaker, BD, Townsend, HG, van Drunen Littel-van den Hurk, S and Griebel, PJ (2012). Mucosal immune response in newborn Holstein calves that had maternally derived antibodies and were vaccinated with an intranasal multivalent modified-live virus vaccine. Journal of the American Veterinary Medical Association 240: 1231–1240.CrossRefGoogle ScholarPubMed
Kelling, CL (2004). Evolution of bovine viral diarrhea virus vaccines. Veterinary Clinics of North America Food Animal Practice 20: 115–129.CrossRefGoogle ScholarPubMed
Lai, VC, Zhong, W, Skelton, A, Ingravallo, P, Vassilev, V, Donis, RO, Hong, Z and Lau, JY (2000). Generation and characterization of a hepatitis C virus NS3 protease-dependent bovine viral diarrhea virus. Journal of Virology 74: 6339–6347.CrossRefGoogle ScholarPubMed
Leyh, RD, Fulton, RW, Stegner, JE, Goodyear, MD, Witte, SB, Taylor, LP, Johnson, BJ, Step, DL, Ridpath, JF and Holland, BP (2011). Fetal protection in heifers vaccinated with a modified-live virus vaccine containing bovine viral diarrhea virus subtypes 1a and 2a and exposed during gestation to cattle persistently infected with bovine viral diarrhea virus subtype 1b. American Journal of Veterinary Research 72: 367–375.CrossRefGoogle ScholarPubMed
Liebler-Tenorio, EM, Ridpath, JE and Neill, JD (2004). Distribution of viral antigen and tissue lesions in persistent and acute infection with the homologous strain of noncytopathic bovine viral diarrhea virus. Journal of Veterinary Diagnostic Investigation 16: 388–396.CrossRefGoogle ScholarPubMed
Liu, D, Lu, H, Shi, K, Su, F, Li, J and Du, R (2014). Immunogenicity of recombinant BCGs expressing predicted antigenic epitopes of bovine viral diarrhea virus E2 gene. Research in Veterinary Science 97: 430–438.CrossRefGoogle ScholarPubMed
Loy, JD, Gander, J, Mogler, M, Vander Veen, R, Ridpath, J, Harris, DH and Kamrud, K (2013). Development and evaluation of a replicon particle vaccine expressing the E2 glycoprotein of bovine viral diarrhea virus (BVDV) in cattle. Virology Journal 10: 35–42.CrossRefGoogle ScholarPubMed
Meyer, G, Deplanche, M, Roux, D, Moulignie, M, Picard-Hagen, N, Lyazrhi, F, Raboisson, D, Mathevet, P and Schelcher, F (2012). Fetal protection against bovine viral diarrhoea type 1 virus infection after one administration of a live-attenuated vaccine. Veterinary Journal 192: 242–245.CrossRefGoogle ScholarPubMed
Mody, KT, Mahony, D, Zhang, J, Cavallaro, AS, Zhang, B, Popat, A, Mahony, TJ, Yu, C and Mitter, N (2014). Silica vesicles as nanocarriers and adjuvants for generating both antibody and T-cell mediated immune responses to Bovine Viral Diarrhoea Virus E2 protein. Biomaterials 35: 9972–9983.CrossRefGoogle ScholarPubMed
Moennig, V, Eicken, K, Flebbe, U, Frey, HR, Grummer, B, Haas, L, Greiser-Wilke, I and Liess, B (2005). Implementation of two-step vaccination in the control of bovine viral diarrhoea (BVD). Preventive Veterinary Medicine 72: 109–114.CrossRefGoogle ScholarPubMed
Neill, JD (2013). Molecular biology of bovine viral diarrhea virus. Biologicals 41: 2–7.CrossRefGoogle ScholarPubMed
Neill, JD, Newcomer, BW, Marley, SD, Ridpath, JF and Givens, MD (2011). Genetic change in the open reading frame of bovine viral diarrhea virus is introduced more rapidly during the establishment of a single persistent infection than from multiple acute infections. Virus Research 158: 140–145.CrossRefGoogle ScholarPubMed
Palomares, RA, Hurley, DJ, Woolums, AR, Parrish, JE and Brock, KV (2014). Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves. Comparative Immunology and Microbiology of Infectious Disease 37: 331–338.CrossRefGoogle ScholarPubMed
Peréz Aguirreburualde, MS, Gómez, MC, Ostachuk, A, Wolman, F, Albanesi, G, Pecora, A, Odeon, A, Ardila, F, Escribano, JM, Dus Santos, MJ and Wigdorovitz, A (2013). Efficacy of a BVDV subunit vaccine produced in alfalfa transgenic plants. Veterinary Immunology and Immunopathology 151: 315–324.CrossRefGoogle ScholarPubMed
Płoneczka-Janeczko, K, Bania, J, Wałecka, E, Bierowiec, K and Rozpedek, W (2013). Reduction of prevalence of persistent BVDV infection in cattle herds by long-term vaccination program (preliminary clinical study). Polish Journal of Veterinary Science 16: 381–387.Google Scholar
Reber, AJ, Tanner, M, Okinaga, T, Woolums, AR, Williams, S, Ensley, DT and Hurley, DJ (2006). Evaluation of multiple immune parameters after vaccination with modified live or killed bovine viral diarrhea virus vaccines. Comparative Immunology and Microbiology of Infectious Disease 29: 61–77.CrossRefGoogle ScholarPubMed
Ridpath, JF (2013). Immunology of BVDV vaccines. Biologicals 41: 14–19.CrossRefGoogle ScholarPubMed
Rodning, SP, Marley, MS, Zhang, Y, Eason, AB, Nunley, CL, Walz, PH, Riddell, KP, Galik, PK, Brodersen, BW and Givens, MD (2010). Comparison of three commercial vaccines for preventing persistent infection with bovine viral diarrhea virus. Theriogenology 73: 1154–1163.CrossRefGoogle ScholarPubMed
van Drunen Littel-van den Hurk, S, Lawman, Z, Snider, M, Wilson, D, van den Hurk, JV, Ellefsen, B and Hannaman, D (2013). Two doses of bovine viral diarrhea virus DNA vaccine delivered by electroporation induce long-term protective immune responses. Clinical and Vaccine Immunology 20: 166–173.CrossRefGoogle ScholarPubMed
Wang, W, Shi, X, Wu, Y, Li, X, Ji, Y, Meng, Q, Zhang, S and Wu, H (2014). Immunogenicity of an inactivated Chinese bovine viral diarrhea virus 1a (BVDV 1a) vaccine cross protects from BVDV 1b infection in young calves. Veterinary Immunology and Immunopathology 160: 288–292.Google Scholar
Woolums, AR, Berghaus, RD, Berghaus, LJ, Ellis, RW, Pence, ME, Saliki, JT, Hurley, KA, Galland, KL, Burdett, WW, Nordstrom, ST and Hurley, DJ (2013). Effect of calf age and administration route of initial multivalent modified-live virus vaccine on humoral and cell-mediated immune responses following subsequent administration of a booster vaccination at weaning in beef calves. American Journal of Veterinary Research 74: 343–354.Google Scholar
Xue, W, Mattick, D, Smith, L, Umbaugh, J and Trigo, E (2010). Vaccination with a modified-live bovine viral diarrhea virus (BVDV) type 1a vaccine completely protected calves against challenge with BVDV type 1b strains. Vaccine 29: 70–76.CrossRefGoogle ScholarPubMed