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Advances in mucosal vaccination

Published online by Cambridge University Press:  28 February 2007

Els N. T. Meeusen ,
Jean-Pierre Y. Scheerlinck ,
Sean Wattegedera  and
Gary Entrican
Els N. T. Meeusen*
Affiliation:
Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Australia
Jean-Pierre Y. Scheerlinck
Affiliation:
Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Australia
Sean Wattegedera
Affiliation:
Moredun Research Institute, Pentlands Science Park, Edinburgh, UK
Gary Entrican
Affiliation:
Moredun Research Institute, Pentlands Science Park, Edinburgh, UK
*
*Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Victoria 3010, Australia
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Abstract

Pathogens that enter the body via mucosal surfaces face unique defense mechanisms that combine the innate barrier provided by the mucus layer with an adaptive response typified by the production and transepithelial secretion of pathogen-specific IgA. Both the measurement and induction of mucosal responses pose significant challenges for experimental and practical application and may need to be adapted to the species under study. In particular, for livestock, immunization procedures developed in small rodent models are not always effective in large animals or compatible with management practices. This paper reviews the latest advances in our understanding of the processes that lead to secretory IgA responses and how this relates to the development of mucosal immunization procedures and adjuvants for veterinary vaccines. In addition, it highlights the complex interactions that can take place between the pathogen and the host's immune response, with specific reference to Chlamydia/Chlamydophila infections in sheep.

Keywords

vaccinationmucusmucosal immunityChlamydiaChlamydophiladendritic cells
Type
Research Article
Information
Animal Health Research Reviews , Volume 5 , Issue 2 , December 2004 , pp. 209 - 217
Copyright
Copyright © CAB International 2004

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