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Zygosity Partitioning of Small Twin Samples

Published online by Cambridge University Press:  01 August 2014

Gordon Allen  and
Zdenek Hrubec
Gordon Allen*
Affiliation:
9326 West Parkhill Drive, Bethesda, Maryland
Zdenek Hrubec
Affiliation:
Radiation Epidemiology Branch, National Cancer Institute, Bethesda, Maryland
*
9326 West Parkhill Drive, Bethesda, MD 20814, USA

Abstract

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When the Weinberg estimate of the proportion of monozygotic pairs is quite deviant from that in the source population, it is likely to be wrong because Weinberg's difference is much less stable than the zygosity proportions. A formula is proposed for the probability distribution of possible compositions of a small sample of twins based on sex concordance in the sample and zygosity proportions in the source population.

Keywords

Twin samplesZygosityLikelihood methodWeinberg's difference
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 34 , Issue 3-4 , October 1985 , pp. 167 - 174
Copyright
Copyright © The International Society for Twin Studies 1985

References

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