Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-26T12:42:27.183Z Has data issue: false hasContentIssue false
  • English
  • Français

The Twin Clinical Method in Dermatology*

Published online by Cambridge University Press:  01 August 2014

R. Cavalieri
R. Cavalieri*
Affiliation:
The Gregor Mendel Institute of Medical Genetics and Twin Research, Rome Institute of Dermatology, I. D. I., Rome
*
Istituto Dermopatico dell'Immacolata, Via Monti di Creta 104, 00167 Roma, Italy

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Genetic skin diseases have been considered with respect to their population and family frequencies, as well as to their concordance values, in MZ and DZ twin pairs. The clinical evolution of the disease has been further considered in its various stages and compared in MZ and DZ twins, concordant for the disease.

The material consisted of 100 twin pairs, with at least one member affected, subdivided with respect to concordance and zygosity. For each dermatosis, then, the population and family frequencies have been calculated. The following dermatoses could be studied: psoriasis, acne vulgaris, keratosis pilaris, alopecia areata, epidermolysis bullosa and dermatitis seborrheica.

A high concordance of clinical evolution in MZ twins has appeared to correspond to a low frequency of the disease, while a high frequency appears to correspond to low concordance values. This finding may be very useful for a better understanding of the disease's inheritance, as well as of its penetrance and expression.

It has been finally possible to evaluate the hereditary quantum vs. the environmental one in the determination of a dermatosis, by means of Holzinger's coefficient of heredity (H). The estimates of the latter vary from 35 to 50% in the various dermatoses examined.

Type
Session 15 - Twins in Medical Genetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 19 , Issue 1-2 , April 1970 , pp. 257
Copyright
Copyright © The International Society for Twin Studies 1970

Footnotes

*

The full paper has meanwhile been published as follows:

R. Cavalieri (1969). Indagine genetica comparativa con il test clinico-gemellare in dermatologia. Cronache dell'I.D.I., 24: 177-185.

References

* The full paper has meanwhile been published as follows:

R. Cavalieri (1969). Indagine genetica comparativa con il test clinico-gemellare in dermatologia. Cronache dell'I.D.I., 24: 177-185.