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Sulla Genetica del Diabete Analisi di nove casi famigliari

Published online by Cambridge University Press:  01 August 2014

L. Gedda ,
D. Casa  and
G. Brenci
L. Gedda*
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
D. Casa
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
G. Brenci
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
*
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Piazza Galeno 5, 00161 Roma, Italy

Summary

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Nine family cases of diabetes are genetically interpreted on account of a polygenic model of inheritance, with each allele being characterized by a different probability of chronological stability of the normal information. This model provides a satisfactory interpretation of the clinical and subclinical variability of diabetes — which the diallelic model is unable to do — and has on the polygenic model the advantage of a higher fitness to a case of discontinuous variability, such as diabetes. Both pedigrees characterized by apparent recessive inheritance and those characterized by apparent dominant one may equally be interpreted on account of the polyallelic model.

The origin of polyallelism is attributed to the hereditary variability of the gene's temporal unit (chronon). As a result, the phenomenon of “anticipation” may also be interpreted, and the one-origin clinical and sub-clinical variability of diabetes be demonstrated.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 19 , Issue 3 , July 1970 , pp. 385 - 398
Copyright
Copyright © The International Society for Twin Studies 1970

References

Bibliografia

Barrai, I., Cann, H. M. (1965). Transmission of diabetes mellitus. J. Med. Genet., 8: 11.Google Scholar
Bartalos, M. (1967). On the concepts of chronon and chronaxy and their implications in neoplasia. Acta Genet. Med. Gemellol., 16: 1.Google Scholar
College of General Practitioners (1965). Report of Working Party. The family history of diabetes. Brit. Med. J., 1: 960.Google Scholar
Fraccaro, M. (1954). Genetical analysis of 955 cases of diabetes mellitus. Caryologia, 6: 1052.Google Scholar
Gedda, L. (1965). Application de la génétique à la pratique médicale. (La constitution au point de vue de la génétique. Le «chronon»: concept et application au service de la médecine). Acta Genet. Med. Gemellol., 14: 1.Google Scholar
Gedda, L., Brenci, G. (1966). Chronological aspects of gene action: a twin study. Acta Genet. Med. Gemellol., 15: 327.Google Scholar
Gedda, L., Casa, D, Brenci, G. (1967). Chronon and the problem of anticipation. (On two family cases of diabetes). Acta Genet. Med. Gemellol., 16: 217.Google Scholar
Gedda, L., Brenci, G. (1969). Biology of the gene; the ergon/chronon system. Acta Genet. Med. Gemellol., 18: 329–379.Google Scholar
Gronberg, A., Larson, T. J., Jung, J. (1967). Diabetes in Sweden. Acta Med. Scand., Suppl. 477.Google Scholar
Hanhart, E. (1950). Neue Forschung-ergebnisse über die Vererbung des Diabetes mellitus. Arch. Klaus. Stift. Vererbungsforsch., 25: 586.Google Scholar
Hanhart, E. (1951). Zur Vererbung des Diabetes mellitus. Schweiz. Med. Wschr., 81: 1127.Google Scholar
Hanhart, E. (1953). Die erbliche Anlage der Zucherkrankheit, heutiger Stand. Deutsch. Z. Verdau. Stoffwechselkr., 13: 1127.Google Scholar
Harris, H. (1950). The familial distribution of diabetes mellitus. A study of the relatives of 1241 diabetic propositi. Ann. Eugen., 15: 95–119.Google Scholar
Harvald, B., Hauge, M. (1963). Selection in diabetes in modern society. Acta Med. Scand., 173: 459–465.Google Scholar
Jörgensen, G. (1966). Zur Genetik des idiopatischen Diabetes mellitus. Deutsch. Med. J., 17: 393–400.Google Scholar
Lamy, M., Frezal, J., de, Grouchy J. (1957). Résultats d'une enquête sur l'hérédité du diabète sucré. Rev. Franc. Etud. Clin. Biol., 2: 907–919.Google Scholar
Rey, J. (1961). Hérédité du diabète sucré. Journées Ann. Diabet. Hotel Dieu, 5: 15.Google Scholar
Levit, S. G., Pessikova, L. N. (1934). The genetics of diabetes mellitus. Proc. Maxim Gorky Med. Biol. Inst. (Moscow), 3: 132–147.Google Scholar
Malins, J. (1968). Clinical Diabetes Mellitus. Ed. Eyre and Spottiswoode.Google Scholar
Marble, A. (1967). Definition and criteria for the prediabetic state. Panel discussion. Congr. Int. Diabet. Feder., Stockholm.Google Scholar
Meier, H., Yerganian, G. A. (1959). Spontaneous hereditary diabetes mellitus in Chinese hamsters. Proc. Soc. Exp. Biol. Med., 100: 810–815.Google Scholar
Neel, J. V., Shaw, M. W., Schull, W. J. (1965). The evaluation of genetic factors in selected illustrative diseases: diabetes mellitus. In: Genetics and the Epidemiology of Chronic Diseases. US Dept. of Health, Education and Welfare. Public Health Service Publ. 1163.Google Scholar
Okamoto, K. (1960). Invention of diabetic disposition and of spontaneous diabetes in the descendants of diabetic animals. Tonyobyo, 3: 33–47.Google Scholar
Pavel, I., Piepter, R. (1966). Etude sur le diabète héréditaire au cours de 3 et 4 générations successives. Diabetologie, 2: 4.Google Scholar
Penrose, L. S. (1948). The problem of anticipation in pedigrees of dystrophia myotonica. Ann. Eugen., 14: 125–132.Google Scholar
Post, R. H. (1962). An approach to the question, does all diabetes depend upon a single genetic locus? Diabetes, 11: 56–65.Google Scholar
Steinberg, A. G. (1959). The genetics of diabetes: a review. Ann. N. Y. Acad. Sci., 82: 2.Google Scholar
Steinberg, A. G. (1965). Genetics and Diabetes. In Leibel, B. S. and Wrenshall, G. A.: On the Nature and Treatment of Diabetes. Excerpta Medica Foundation, Amsterdam.Google Scholar
Steinberg, A. G. Wilder, R. M. (1952 a). An analysis of the phenomenon of “anticipation” in diabetes mellitus. Ann. Intern. Med., 36: 1285.Google Scholar
Steinberg, A. G. Wilder, R. M. (1952 b). A study of the genetics of diabetes mellitus. Amer. J. Hum. Genet., 4: 113–135.Google Scholar
Stimmler, L., Elliot, R. B. (1964). Inheritance of a diabetic-serum factor inhibiting normal utilization of insulin. Lancet, 1: 956.Google Scholar
Then Berg, H. (1938 a). Die Erbbiologie des Diabetes, vorlaufiges Ergebnis der Zwillinge-untersuchungen. Arch. Rassenbiol., 32: 289.Google Scholar
Then Berg, H. (1938 b). The genetic aspect of diabetes mellitus. Foreign letters, Berlin. J.A.M.A., 112: 1091–1939.Google Scholar
Vallance-Owen, J. (1963). Antagonists of Insulin. In Oberdisse, K. and Jahnke, K.: Fortschritte der Diabetesforschung. G. Thieme Verlag, Stuttgart.Google Scholar
Vallance-Owen, J. (1964). Synalbumin Insulin Antagonism and Diabetes. In: Colloquia on Endocrinology. Churchill, London.Google Scholar
White, P. (1959). Evidence in favor of the Theory that Diabetes is Inherited. In Joslin, E. P.: Treatment of Diabetes Mellitus. 10th Ed., Lea and Febiger, Philadelphia.Google Scholar