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Some Biomedical Indicators in Chronogenetics

Published online by Cambridge University Press:  01 August 2014

M. Milani Comparetti ,
D.P. Pace ,
F. Britti  and
D. Casini
M. Milani Comparetti*
Affiliation:
Institute of Biology and Genetics, Medical School, Ancona, Italy
D.P. Pace
Affiliation:
Institute of Biology and Genetics, Medical School, Ancona, Italy
F. Britti
Affiliation:
The Gregor Mendel Institute for Medical Genetics and Twin Studies, Rome, Italy
D. Casini
Affiliation:
The Gregor Mendel Institute for Medical Genetics and Twin Studies, Rome, Italy
*
Istituto di Biologia e Genetica, Facoltà di Medicina dell'Università, Ancona, Italy

Abstract

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All living beings are variously conditioned by both continuous and repetitive chronological phenomena.

The greater biochemical complexity afforded by the genome of higher organisms contributes to increase their independence from environmental chronological phenomena (= increased homeostasis). Genetic variability (originated by mutations and required for evolutionary adaptation) extends its influence on the biochemical mechanisms of homeostasis.

Phenotypical variability, if prevailing environmental conditions are constant, is based on genotypical variability. Thus the variability observed in the duration of homeostatic mechanisms must be genotypical.

In current chronogenetical theory, Gedda and Brenci's concept of the Ergon) Chronon System provides the explanation for the observed variability in the duration of homeostatic phenomena; in this concept, the differential stability of genie information explains the variation of patterns of senescence in different individuals. From the viewpoint of the continuity of life, senescence must be considered as “physiological”, but its individual, especially initial degenerative manifestations are generally considered as pathological. The fundamental applications of chronogenetics to the human species are to be aimed in this direction.

Individual phenomena of senescence may be more or less linear; the pattern of the respective curves may be common to the entire species, or else it may afford varying degrees of variability. The ascertainment of the respective curves (for which some indicators may serve as examples) is a prerequisite for the application of chronogenetics to the individual, framing him within his genealogy and providing great potential developments for preventive medicine.

Type
4. Chronogenetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 23 , supplement S1 , January 1974 , pp. 145 - 156
Copyright
Copyright © The International Society for Twin Studies 1974

References

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