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Screening for Multiple Pregnancy Determination of Human Chorionic Gonadotropin (hCG), Alpha-Fetoprotein (α-FP) and Human Placental Lactogen (hPL) in Blood During the Second Trimester of Pregnancy

Published online by Cambridge University Press:  01 August 2014

F. Vandekerckhove ,
M. Dhont ,
M. Thiery  and
R. Derom
F. Vandekerckhove*
Affiliation:
Department of Obstetrics and Gynecology, University of Gent, Belgium
M. Dhont
Affiliation:
Department of Obstetrics and Gynecology, University of Gent, Belgium
M. Thiery
Affiliation:
Department of Obstetrics and Gynecology, University of Gent, Belgium
R. Derom
Affiliation:
Department of Obstetrics and Gynecology, University of Gent, Belgium
*
Department of Obstetrics and Gynecology, De Pintelaan 185, 9000 Gent, Belgium

Abstract

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The value of single determinations of serum hCG, hPL, and αFP for the detection of multiple pregnancy was investigated in a consecutive series of 992 women between the 14th and 24th week of pregnancy. With the 90th percentile as referent value, all twin pregnancies (n = 10) were detected by the combined results of the three determinations. Considered separately, hPL proved to be the most useful indicator of multiple gestation; the sensitivity of hPL alone was 70% and the predictive value of hPL concentrations above the 90th percentile was 8.1.

Keywords

Chorionic gonadotropinAlpha-fetoproteinHuman placental lactogenTwin pregnancy
Type
Short Note
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 4 , October 1984 , pp. 571 - 574
Copyright
Copyright © The International Society for Twin Studies 1984

References

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