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Possible Linkage Relationship Between Genetic Markers and Blood Magnesium and Zinc A Twin Study

Published online by Cambridge University Press:  01 August 2014

P. Darlu ,
E. Defrise-Gussenhoven ,
Y. Michotte ,
C. Susanne  and
J.G. Henrotte
P. Darlu*
Affiliation:
Groupe de Recherches de Génétique Epidémiologique, INSERM, Paris R.C.P. Magnésium et Oligoéléments, CNRS, Faculté de Pharmacie, Paris
E. Defrise-Gussenhoven
Affiliation:
Laboratorium Antropogenetika, Vrije Universiteit, Brussels
Y. Michotte
Affiliation:
Pharmaceutical Institute, Brussels
C. Susanne
Affiliation:
Laboratorium Antropogenetika, Vrije Universiteit, Brussels
J.G. Henrotte
Affiliation:
R.C.P. Magnésium et Oligoéléments, CNRS, Faculté de Pharmacie, Paris
*
Groupe de Recherches de Génétique Epidémiologique, INSERM U. 155, Château de Longchamp, 75016 Paris, France

Abstract

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In a sample of 63 like-sex dizygotic twins, red blood ceE and plasma magnesium and red blood cell zinc concentrations were analyzed for linkage to each of 23 genetic systems by estimating correlation between proportion of genes identical by descent and biological resemblance for the trait. The results suggest possible linkage of red blood cell magnesium with the HLA locus and of red blood cell zinc with the GLO1 locus. However, studies applying more powerful tests are needed to confirm such conclusions.

Keywords

LinkageMagnesiumZincTwinsSib-pair methodMarker loci
Type
Short Note
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 34 , Issue 1-2 , April 1985 , pp. 109 - 112
Copyright
Copyright © The International Society for Twin Studies 1985

References

REFERENCES

1. Blackwelder, WC, Elston, RC (1974): Comment on Dr. Robertsons's communication. Behav Genet 4:97–99.CrossRefGoogle ScholarPubMed
2. Blackwelder, WC, Elston, RC (1982): Power and robustness of sibpair linkage tests and extension to larger sibships. Commun Stat Theory Methods, 11:449–484.Google Scholar
3. Brocteur, J, Hoste, B, André, A (1980): Plasma protein and enzyme polymorphismes in Belgium. Hum Hered 4:221–224.CrossRefGoogle Scholar
4. Darlu, P, Moreau, Th (1978): Twin studies of blood ionic content. In Nance, WE, Allen, G, Parisi, P (eds): Twin Research: Part C, Clinical Studies. New York: Alan R Liss, p 177–185.Google Scholar
5. Darlu, P, Henrotte, JG (1980): The importance of genetic and constitutional factors in human red blood cell magnesium control. In Cantin, M, Seelig, MS (eds): Magnesium in Health and Disease. Spectrum Publications, p 921–927.Google Scholar
6. Darlu, P, Michotte, Y, Defrise-Gussenhoven, E, Henrotte, JG (1980): The inheritance of plasma and red blood cell magnesium and zinc levels studied from twin and family data. Acta Genet Med Gemellol 30:67–75.Google Scholar
7. Darlu, P, Rao, DC, Henrotte, JG, Lalouel, JM (1982): Genetic regulation of plasma and red blood cell Magnesium concentrations in Man. I. Univariate and bivariate path analyses. Am J. Hum Genet 34:874–887.Google Scholar
8. Darlu, P, Lalouel, JM, Henrotte, JG, Rao, DC (1983): A genetic study of red blood cell zinc concentration in man. Hum Hered 33:311–318.CrossRefGoogle ScholarPubMed
9. Defrise-Gussenhoven, E, Susanne, CH, Michotte, Y, Brocteur, J, Hoste, B (1981): Are distances between DZ twins for polygenes and for major genes correlated? In Gedda, L, Parisi, P, Nance, WE (eds): Twin Research 3: Part C, Epidemiological and Clinical Studies. New York: Alan R. Liss, p 239–246.Google Scholar
10. Defrise-Gussenhoven, E, Susanne, C, Orban-Segebarth, R (1982): Biometrie des jumeaux belges agés de 18 à 25 ans. Bull Mem Soc Anthropol Paris, 13:117–189.Google Scholar
11. Elston, RC, Stewart, J (1971): A general model for the genetic analysis of pedigree data. Hum Hered 21:523–542.CrossRefGoogle ScholarPubMed
12. Haseman, JK, Elston, RC (1972): The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3–19.Google Scholar
13. Hiller, C, Bischoff, M, Schmidt, A, Bender, K (1978): Analysis of the HLA-ABC linkage desequili-brium decreasing strength of gametic association with increasing map distance. Hum Genet 41: 301–312.Google Scholar
14. Henrotte, JG, Benech, A, Pineau, M (1980): Relationship between blood magnesium content and age in a French population. In Cantin, M, Seelig, MG (eds): Magnesium in Health and Disease. Spectrum Publications, p 929–934.Google Scholar
15. Henrotte, JG (1977): Relations entre magnesium, zinc érythrocytaire et groupes HLA. CR Acad Sci 285 D: 737–739.Google Scholar
16. Henrotte, JG (1980): The variability of human red blood cell magnesium level according to HLA groups. Tissue Antigens 15:419–439.Google Scholar
17. Lalouel, JM, Morton, NE (1981): Complex segregation analysis with pointer. Hum Hered 31:312–321.CrossRefGoogle Scholar
18. Lalouel, JM, Darlu, P, Henrotte, JG, Rao, DC (1983): Genetic regulation of plasma and red blood cell magnesium concentration in man. II Segregation analyses. Am J Hum Genet 35:938–950.Google Scholar
19. Morton, NE, McLean, CJ (1974): Analysis of family resemblance. III. Complex segregation analysis of quantitative traits. Am J Hum Genet 26:489–503.Google Scholar
20. Robertson, A (1973): Linkage between marker loci and those affecting a quantitative trait. Behav Genet 3:389–391.Google Scholar