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Physiologic Variation Of Renal Function In Twins: Diuresis After Water Intake1

Published online by Cambridge University Press:  01 August 2014

Bertha M. Aschner  and
Stanley M. Gartler
Bertha M. Aschner
Affiliation:
Institute for the Study of Human Variation, Columbia University, New York, N. Y.
Stanley M. Gartler
Affiliation:
Institute for the Study of Human Variation, Columbia University, New York, N. Y.

Summary

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In six monozygotic and six dizygotic healthy twin pairs the urine elimination after rapid drinking of 1000 cc of water (Fishberg-Volhard test) was studied. Considerabbe variation wes observed in the diuretic response of these individuals, particularly in the maximum rate of the reactive diuresis. The minute volumes of urine during the half-hour period of the largest output were compared between the partners of each twin pair. It was found that the difference of the maximum rate of urine flow was significantly (0.01 level) smaller between one-egg than between two-egg twins under otherwise equal conditions. The concept of genetic factors controlling the function of the renal tubular cells is discussed.

Riassunto

RIASSUNTO

Fu studiata l'eliminazione dell'orina, dopo aver bevuto velocemente 1000 cc. d'acqua, in sei paia di gemelli uniovulari e sei paia di biovulari. Variazioni considerevoli della reazione diuretica furono osservate in questi individui, specialmente nella forza massima della diuresi reattiva. Abbiamo comparato i volumi dell'orina per minuto durante la mezz'ora di massima eliminazione fra i co-gemelli di ogni paio. Abbiamo trovato che la differenza nella forza massima della diuresi era significativamente (livello di 0,01) più piccola fra gemelli unovulari che fra biovulari sotto condizioni altrimenti uguali. Si discute il concetto d'un controllo genetico della funzione cellulare dei tubuli renali.

Zusammenfassung

ZUSAMMENFASSUNG

An sechs eineiigen und sechs zweieiigen Zwillingspaaren wurde die Diurese nach einem Wasserstoss (Volhards Probe) von 1000 cc verfolgt. Diese Versuchspersonen zeigten beträchtliche Variationen ihler diuretischen Reaktion, insbesondere in der maximalen Intensität ihrer reaktiven Diurese. Das Minutenvolumen des Harns vährend der halben Stunde intensivster Ausscheidung wurde zwischen den Partnern jedes einzelnen Paares verglichen. Es ergab sich, dass die Differenz der maximalen Intensität der Harnflut unter sonst gleichen Versuchsbedingungen zwischen eineiigen Zwillingen bedeutend kleiner war als zwischen zweieiigen. Dieser Unterschied lag weit ausserhalb der statistischen Fehlergrenzen. Die Annahme einer genetischen Kontrolle der Zellfunktion der Nierentubuli wird besprochen.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 7 , Issue 1 , January 1958 , pp. 19 - 24
Copyright
Copyright © The International Society for Twin Studies 1958

Footnotes

1

This work was supported by a grant from the National Science Foundation.

References

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