Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-25T01:48:52.100Z Has data issue: false hasContentIssue false
  • English
  • Français

Pharmacogenetics and the Detoxicant Powers of the Organism

Published online by Cambridge University Press:  01 August 2014

Luigi Gedda
Luigi Gedda*
Affiliation:
Istituto di Genetica Medica e Gemellologia « G. Mendel », Roma

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Pharmacogenetics represents a field of connection and cooperation between pharmacology and genetics, which will promote knowledge in both fields. It concerns the plusvariant action of drugs in those families in which they produce toxic reactions, as well as the minusvariant action in particularly resistant families, so that drugs become useless at normal doses. These phenomena stress both the mechanism of action of such drugs and the existence of hereditary metabolic defects. Some typical cases are reported, with special concern to twin observations. It is finally suggested that pharmacogenetics may concern three specific branches: (a) regulation, (b) substitution and (c) repair.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 18 , Issue 3 , July 1969 , pp. 219 - 230
Copyright
Copyright © The International Society for Twin Studies 1969

References

Bibliografia

Armaly, M. F. (1965). Statistical attributes of the steroid hypertensive response in the clinically normal eye. I. The demonstration of three levels of response. Invest. Ophthal., 4: 187.Google Scholar
Armaly, M. F. (1966). The heritable nature of dexamethasone — induced ocular hypertension. Arch. Ophthal., 75: 32.Google Scholar
Armaly, M. F. 1967). Inheritance of dexamethasone hypertension and glaucome. Arch. Ophthal., 77: 747.CrossRefGoogle Scholar
Armaly, M. F. (1967). Dexamethasone ocular hypertension and eosinopenia and glucose tolerance test. Arch. Ophthal., 78: 193.Google Scholar
Becker, B., (1965). Intraocular pressure response to topical corticosteroids. Invest. Ophthal., 4: 198.Google Scholar
Becker, B., (1967). Topical Corticosteroids and Intraocular Pressure. Current Concepts in Ophthalmology. C. V. Mosby & Co.Google Scholar
Becker, B., Hahn, K. A. (1964). Topical corticosteroids and heredity in primary open-angle glaucoma. Amer. J. Ophthal., 57: 543.Google Scholar
Bracco, M., Savio, E. (1961). Tassi ematici dell'isoniazide. Nota II. Rapidi e lenti inattivatori dell'INI nella popolazione sanatoriale del Villaggio Morelli di Sondalo. Annali Med. Sondalo, 4: 206.Google Scholar
François, J., Heintz-De Bree, C., Tripathi, R. C. (1966). The cortisone test and the heredity of primary open-angle glaucoma. Amer. J. Ophthal., 62: 844.CrossRefGoogle ScholarPubMed
Gaffuri, G. (1969). Le reazioni gustative alla E.P.T.C. in gemelli MZ. Proc. 1st Int. Symp. Twin Studies, Rome. (In press).Google Scholar
Gedda, L. (1928). Un trattato di terapia agli inizi dell'Evo moderno. Riv. Storia delle Scienze Mediche e Naturali, XIX, 7-8, 9–10.Google Scholar
Gedda, L. (1968). Caratteristiche attuali del clima di media quota nella profilassi e nella terapia. Cerro Veronese.Google Scholar
Gedda, L., Scullica, L., Accardi, A. (1969). Glaucoma concordante in gemelli MZ. Proc. 1st Int. Symp. Twin Studies, Rome. (In press).Google Scholar
Gedda, L., Brenci, G. (1969). Studies on Gene Biology: the Ergon-Chronon System. Acta Genet. Med. Gemellol. (In press).Google Scholar
Jörgensen, G., Lenz, W., Pfeiffer, R. A., Schaafhausen, Ch. (1969). Thalidomide-Embryopathie in Twins. A Collaborative Study. Proc. 1st Int. Symp. Twin Studies, Rome. (In press).Google Scholar
Kabakow, W. (1962). Pharmacogenetics. Heredity and the Response to Drugs. Saunders, London.Google Scholar
Mascherpa, P. (1963). Farmacogenetica ed azione teratogena dei farmaci. Atti 12° Convegno Farmacisti Alta Italia.Google Scholar
Mascherpa, P. (1966). Farmacogenetica ed organotropismo dei farmaci. XIII Convegno della Salute, Ferrara.Google Scholar
Mascherpa, P. (1966). Nel centenario mendeliano. Farmacogenetica e Tossicologia. Rassegna Clinico-Scientifica, 42: 6.Google Scholar
Mascherpa, P. (1967). Organotropism and possible functional changes induced in the foetus by some psychotropic drugs. Teratology. N° 173. Excerpta Medica International Congress Series, Como Symposium.Google Scholar
Meier, H. (1963). Experimental Pharmacogenetics. Academic Press, London.Google Scholar
O'Reilly, R. A., Aggler, P. M., Hoag, M. W., Leong, L. S. Kropatkin, M. L. (1964). Hereditary transmission of exceptional resistance to coumarin anticoagulant drugs. The first reported kindred. New Eng. J. Med., 15.Google Scholar
Price-Evans, D. A. (1961). Pharmacogenetics. In L. Gedda: De Genetica Medica. Ed. Istituto Mendel, Roma. (In press).Google Scholar
Reuling, F. H., Schwartz, J. T. (1969). Heritability of the effect of corticosteroids on intraocular pressure. Proc. 1st Int. Symp. Twin Studies, Rome. (In press).Google Scholar
Shideman, F. E. (1967). “Take as directed” our modern medicines. The Chemical Rubber, Cleveland.Google Scholar
Schwartz, B. (1966). The response of ocular pressure to corticosteroids. Inter. Ophthal. Clinics. Little Brown & Co., 6: 4.Google Scholar