Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-20T15:22:32.040Z Has data issue: false hasContentIssue false
  • English
  • Français

Ophthalmic Disease in Twins: A Nationwide Record Linkage Study of Hospital Discharges and Free Medications for 16,067 Twin Pairs

Published online by Cambridge University Press:  01 August 2014

J.M. Teikari ,
J. Kaprio ,
M. Koskenvuo  and
A. Vannas
J.M. Teikari*
Affiliation:
Department of Public Health Science, University of Helsinki
J. Kaprio
Affiliation:
Department of Public Health Science, University of Helsinki
M. Koskenvuo
Affiliation:
Department of Public Health Science, University of Helsinki
A. Vannas
Affiliation:
Helsinki Military Hospital, Finland
*
Department of Public Health Science, Haartmaninkatu 3, 00290 Helsinki 29, Finland

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Record linkage of the Finnish Twin Cohort Study with the Hospital Discharge Registry and with the Registry of Rights to Free Medication kept by the Social Insurance Institution gave following numbers of twin pairs with an ophthalmic disease (one or both members of the pair had the disease) in each disease category:98 with glaucoma simplex (5 concordant pairs), 38 with capsular glaucoma (no concordant pairs), 58 with iritis (no concordant pairs) and 149 with strabismus (2 concordant pairs).

The number of concordant pairs in each disease category was small, except for glaucoma simplex in which concordant pairs could be broken down by zygosity. The ratio of observed to expected (based on association by chance) was 6.96 for MZ and 1.74 for DZ pairs. This result suggests that genetic factors play some role in the variability of prevalence of simple glaucoma. Main etiologic factors are stili to be found in the environment. Data on occurrence of other diseases of ophtalmologic importance is presented.

Keywords

TwinHeritabilityGlaucomaStrabismusIritis
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 36 , Issue 4 , October 1987 , pp. 523 - 534
Copyright
Copyright © The International Society for Twin Studies 1987

References

REFERENCES

1. Allen, G (1979): Holzinger's revised. Acta Genet Med Gemellol 28:161–164.Google Scholar
2. Allen, G, Hrubec, Z (1979): Twin concordance. A more general model. Acta Genet Med Gemellol 28:3–13.Google Scholar
3. Armaly, MF (1967): Genetic determination of cup/disc ratio of the optic nerve. Arch Ophthalmol 78:35–43.Google Scholar
4. Armaly, MF (1977): The genetic determination of the ocular pressure in the normale eye. Arch Ophthalmol 78:187–192.CrossRefGoogle Scholar
5. Armaly, MF, Monstavicius, BF, Sayegh, RE (1968): Ocular pressure and aqueous outflow facility in siblings. Arch Ophthalmol 80:354–360.Google Scholar
6. Armali, MF, Krueger, DE, Maunder, L, Becker, B, Hetherington, J Jr, Koller, AE, Levene, RZ, Maumenee, AG, Pollack, IP, Shaffer, RN (1980): Biostatistical analysis of the collaborative glaucoma study. I. Summary report of the risk factors for glaucomatous visual-field defects. Arch Ophthalmol 98:2163–2171.Google Scholar
7. Bankes, JLK, Perkins, ES, Tsolakis, S, Wright, JA (1968): Bedford Glaucoma Survey. Br Med J 1:791–796.Google Scholar
8. Colton, T (1974): Statistics in Medicine. Boston: Little, Brown & Co.Google Scholar
9. Danning, H (1981): Twin study on myopia. Chinese Med 94:51–55.Google Scholar
10. Duke-Elder, ST, Perkins, EJ (1966): System of Ophthalmology. Diseases of the Uveal Tract. London: Henry Kimpton.Google Scholar
11. Francois, J (1981): Genetic predisposition to glaucoma. In Straub, W (ed): Developments in Ophthalmology. Vol 3: Current Genetic, Clinical and Morphologic Problems. New York: S. Krager, pp 1–45.Google Scholar
12. Heliövaara, M, Reunanen, A, Aromaa, A, Knekt, P, Aho, K, Suhonen, O (1984): Validity of hospital discharge data in a prospective epidemiological study on stroke and myocardial infarction. Acta Med Scand 216:309–315.CrossRefGoogle Scholar
13. Jancke, G, Holste, A (1941): Der Einfluss von Erblichkeit und umwelt auf die Refraktionsentstehung. Eine Zwilligsstudie. Klinishe Mntsbl Augenheilk 107:373–389.Google Scholar
14. Kaprio, j, Sarna, S, Koskenvuo, M, Rantasalo, I (1978): The Finnish Twin Registry: formation and compilation, questionnaire study, zygosity determination procedures and research program. Prog Clin Biol Res 24:179–184.Google Scholar
15. Kaprio, J, Koskenvuo, M, Artimo, M, Sarna, S, Rantasalo, I (1979): The Finnish Twin Registry: Baseline Characteristics. Section I. Materials, Methods, Representativeness and Results for Variables Special to Twin Studies. Kansanterveystieteen julkaisuja M47.Google Scholar
16. Karlsson, JL (1976): Genetic factors in myopia. Acta Genet Med Gemellol 25:292–294.Google Scholar
17. Knobloch, WH, Leavenworth, NM, Bouchard, TJ (1985): Eye findings in twins reared apart. Ophthal Pediatr Genet 5:59–66.Google ScholarPubMed
18. Leske, CM (1983): The epidemiology of open-angle glaucoma: a review. Am J Epidemiol 118: 166–191.Google Scholar
19. Nakajima, A, Kimura, T, Kitamura, K, Uesugi, M, Handa, Y (1968): Studies on the heritability of some metric traits of the eye and the body. Jap J Hum Genet 13:20–39.Google Scholar
20. Phels, CD, Podos, SM (1974): Glaucoma. In Goldberg, MF (ed): Genetic and Metabolic Eye Disease. Boston: Little Brown, pp 237–259.Google Scholar
21. Poikolainen, K (1983): Accuracy of hospital discharge data: five alcohol-related diseases. Drug and Alcohol Dependence 12:315–322.Google Scholar
22. Ren-Yuan, C, Ping-Kuan, K, Yong-Fang, W, Guo-Ming, W (1982): Myopia incidence among twins and its genetic law. In Henkind, P, Shimizu, K, Biodi, FC, Polack, FM, Veroneau-Troutman, S (eds): Acta: XXIV International Congress of Ophthalmology. JB Lippincott Co, pp 84–86.Google Scholar
23. Richter, S (1967): Untersuchungen über die Heredität des Strabismus concomitans. Abhandlungen aus dem Gebiete der Augenheilkunde. Sammlung von Monographies. Leipzig: Georg Thieme, p. 35.Google Scholar
24. Saari, M, Miettinen, R, Tiilikainen, A, Herva, E, Lahti, R (1985): Acute anterior uveitis and HLA-B27 in families. Can J Ophthalmol 12:4–11.Google Scholar
25. Sarna, S (1977): Zygosity Diagnosis in Epidemiological Twin Studies by Blood Marker and by Questionnaire. Academic Dissertation, Helsinki.Google Scholar
26. Sarna, S, Koskenvuo, M, Kaprio, J Rantasalo, I (1976): The Dataprocessing Procedures of the Finnish Twin Register: Compilation and Mailing. Publications of the Department of Public Health Science M19, Helsinki.Google Scholar
27. Sarna, S, Kaprio, J, Sistonen, P, Koskenvuo, M (1978): Diagnosis of twin zygosity by mailed questionnaire. Hum Hered 28:241–254.Google Scholar
28. Schwartz, JT (1976): A monozygotic cotwin control study of treatment for myopia. Acta Genet Med Gemellol 25:133–136.Google Scholar
29. Schwartz, JT, Reuling, FH, Feinleib, M, Garrison, RJ, Collie, DJ (1973): Twin study on ocular pressure after topical dexamethasone. Am J Ophthalmol 76:126–136.Google Scholar
30. Schwartz, JT, Reuling, FH, Garrison, RJ (1975): Acquired cupping of the optic nerve head in normotensive eyes. Br J Ophthalmol 59:216–222.Google Scholar
31. Segal, P, Skierzynska, J (1967): Mass screening of adults for glaucoma. Ophthalmol 153:336–348.Google Scholar
32. Smith, C (1974): Concordance in twins: methods and interpretation. Am J Hum Genet 26:454–466.Google Scholar
33. Sorsby, A, Sheridan, M, Leary, GA (1962): Refraction and its Components in Twins. Special Report Series N 303. London: Medical Research Council, Her Majesty's Stationery Office.Google Scholar
34. Strömberg, U (1962): Ocular hyperthension. Acta Ophthalmol Supp 69:7–75.Google Scholar
35. Teikari, JM, Raivio, I (1987): Validity of hospital discharge registry in acute glaucoma. Acta Ophthalmol 65:589–590.CrossRefGoogle ScholarPubMed
36. National Center for Health Statistics (1980): The Status of Hospital Discharge Data in Six Countries. Data Evaluation and Methods Research, Series 2, N 80. DHEW publication N (PHS) 80–1354.Google Scholar
37. Waardenburg, PJ (1954): Squint and heredity. Doc Ophthalmol 7-8:422–494.Google Scholar