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On the Distribution of Nonrighthandedness Among Twins and Their Families

Published online by Cambridge University Press:  01 August 2014

Charles E. Boklage
Charles E. Boklage*
Affiliation:
East Carolina University School of Medicine, Greenville, North Carolina
*
Department of Microbiology, East Carolina University School of Medicine, Greenville, NC 27834, USA

Abstract

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In 773 three-generation families of twins, individual probability of nonrighthandedness (NRH) depends significantly on the handedness of that individual's parents. The parents of twins are much more often NRH than are their nontwinbearing siblings. The twins and their siblings apparently inherit the excess liability for NRH shown by their parents. Monozygotic (MZ) pairs are significantly about twice as often concordant (casewise) for handedness as dizygotic (DZ) pairs. Overall, the best-fitting mode of transmission is autosomal, NRH dominant to RH with penetrance of about 50% in the heterozygote, or multifactorial, with heritability of 60–70%. Under the major-gene approach, heterogeneity seems likely, with about one-third of the families showing no NRH outside of the twin sibships. MZ/DZ concordance ratio is about four in those families, suggestive of recessive inheritance. A 1.16-fold excess of NRH in twins compared to their siblings, and a 1.8-fold excess in the second-born members of same-sex discordant pairs, leaves open the possibility that a minor portion of NRH in twins may be secondary to transient hypoxia and/or acidosis.

Keywords

HandednessLateralityCerebral dominanceCell differentiationEmbryogenesisBehaviorTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 30 , Issue 3 , July 1981 , pp. 167 - 187
Copyright
Copyright © The International Society for Twin Studies 1981

References

REFERENCES

1.Annett, M (1972): The distribution of manual asymmetry. Br J Psychol 63(3):343–358.CrossRefGoogle ScholarPubMed
2.Annett, M (1978): “A Single Gene Explanation of Left and Right Handedness and Brainedness.” Coventry: Lanchester Polytechnic.Google Scholar
3.Annett, M (1979): Family handedness in three generations predicted by the right shift theory. Ann Hum Genet 42:479–491.CrossRefGoogle ScholarPubMed
4.Austin, CR (1961): “The Mammalian Egg.” Oxford: Blackwell Scientific Publications (Fig. 63; pg 74).CrossRefGoogle Scholar
5.Bakan, P (1971): Handedness and birth order. Nature 229:195. Bakan P, Dibb, G, Reed, P (1973): Handedness and birth stress. Neuropsychologia 11:363-366.CrossRefGoogle ScholarPubMed
6.Boklage, CE (1977): Schizophrenia, brain asymmetry development, and twinning: Cellular relationships with etiological and possibly prognostic implications. Biol Psychiatry 12(1):19–35.Google ScholarPubMed
7.Boklage, CE (1977): Discussion paper: Embryonic determination of brain programming asymmetry – A caution concerning the use of data on twins in genetic inferences about mental development. In Dimond, SJ, Blizard, DA (eds): “Evolution and Lateralization of the Brain.” Ann NY Acad Sci 299:306–308.CrossRefGoogle ScholarPubMed
8.Boklage, CE (1978): On cellular mechanisms for heritably transmitting structural information. Behav Brain Sci 2:282–286.CrossRefGoogle Scholar
9.Boklage, CE (1980): The sinistral blastocyst: An embryonic perspective on the development of brain-function asymmetries. In Herron, J (ed): “Neuropsychology of Left-Handedness.” New York: Academic Press, pp 115–137.Google Scholar
10.Boklage, CE (1981): On the timing of monozygotic twinning events. In Gedda, L, Parisi, P, and Nance, WE (eds): “Twin Research 3, Part A – Twin Biology and Multiple Pregnancy.” New York: Alan R. Liss, Inc., pp 155–165.Google Scholar
11.Boklage, CE, Elston, RC, Potter, RH (1979): Cellular origins of functional asymmetries: Evidence from schizophrenia, handedness, fetal membranes and teeth in twins. In Gruzelier, JH, FlorHenry, P (eds): “Hemisphere Asymmetries of Function in Psychopathology.” London: Elsevier-North Holland, pp 79–104.Google Scholar
12.Boklage, CE, Elston, RC, Potter, RH (1980): Zygosity-related differences in developmental integration. Third International Congress on Twin Studies, Jerusalem.Google Scholar
13.Carter-Salzman, L, Scarr-Salapatek, S, Barker, WB, Katz, S (1976): Left-handedness in twins: Incidence and patterns of performance in an adolescent sample. Behav Genet 6(2): 189–203.CrossRefGoogle Scholar
14.Christian, JC, Hunter, DS, Evans, MM, Standeford, SM (1980): Association of handedness and birth order in monozygotic twins. Acta Genet Med Gemellol 28:67–68.Google Scholar
15.Cohen, DJ, Dibble, ED, Grawe, JM, Pollin, W (1975): Reliably separating identical from fraternal twins. Arch Gen Psych 32:1371–1375.Google Scholar
16.Collins, RL (1977): Origins of the sense of asymmetry: Mendelian and non-Mendelian models of inheritance. In Diamond, SJ, Blizard, DA (eds): “Evolution and Lateralization of the Brain.” Ann NY Acad Sci 299:283–305.Google Scholar
17.Corballis, MC, Morgan, MJ (1978): On the biological basis of human laterality: I. Evidence for a maturational left-right gradient. II. The mechanisms of inheritance. (Open peer commentary follows). Behav Brain Sci 1(2):261–336.Google Scholar
18.Derom, R, Thiery, M (1974): Intrauterine hypoxia – A phenomenon proper to the second twin. Acta Genet Med Gemellol 23:54 (absract).CrossRefGoogle Scholar
19.Elston, RC, Boklage, CE (1978): An examination of fundamental assumptions of the twin method. In Nance, WE, Allen, G, Parisi, P (eds): “Twin Research, Part A – Psychology and Methodology,” vol 24A. Progress in Clinical and Biological Research. New York: Alan R. Liss, Inc.Google Scholar
20.Emery, AEH (1976): “Methodology in Medical Genetics.” Edinburgh: Churchill Livingstone.Google Scholar
21.Eriksson, AW (1973): “Human Twinning in and Around the Aland Islands. Commenationes Biologicae. Helsinki: Societas Scientiarum Fennica.Google Scholar
22.Eriksson, AW, Fellman, J (1976): Twinning in relation to the marital status of the mother. Acta Genet Statist Med 17:385–398.Google Scholar
23.Falek, A (1959): Handedness: A family study. Am J Hum Genet 11:52–62.Google Scholar
24.Fleiss, JL (1973): “Statistical Methods for Rates and Proportions.” New York: John Wiley and Sons, pp 109–113.Google Scholar
25.Gruzelier, JH, Flor-Henry, P (eds): “Hemisphere Asymmetries of Function in Psychopathology.” Developments in Psychiatry, Vol 3. Amsterdam: Elsevier/North Holland.Google Scholar
26.Harlap, S (1980): Twin pregnancies following conceptions on different days of the menstrual cycle. Paper given at Third International Congress on Twin Studies, Jerusalem.Google Scholar
27.Harnad, S, Doty, RW, Goldstein, L, Jaynes, J, Krauthamer, G (1977): “Lateralization in the Nervous System.” New York: Academic Press.Google Scholar
28.Hay, S, Wehrung, DA (1970): Congenital malformations in twins. Am J Hum Genet 22:662–678.Google Scholar
29.Herron, J (ed): “Neuropsychology of Lefthandedness.” New York: Academic Press, 1980.Google Scholar
30.Layde, PM, Erickson, JD, Falek, A, McCarthy, BJ (1980): Congenital malformations in twins. Am J Hum Genet 32:69–78.Google ScholarPubMed
31.Levy, J, Nagylaki, T (1972): A model for the genetics of handedness. Genetics 72:117–128. Nagylaki T, Levy, J (1973): “The sound of one paw clapping” isn't sound. Behav Genet 3:298-303.Google Scholar
32.Levy, J (1977): The origins of lateral asymmetry. In Harnad, S, Doty, RW, Jaynes, J, Goldstein, L, Kranthamer, G (eds): “Lateralization in the Nervous System.” New York: Academic Press, pp 195–209.CrossRefGoogle Scholar
33.McManus, JC (1980): Handedness in twins: A critical review. Neuropsychologia 18:347–355.CrossRefGoogle ScholarPubMed
34.Myrianthopoulos, NC (1970): An epidemiologic survey of twins in a large, prospectively studied population. Am J Hum Genet 22:611–629.Google Scholar
35.Myrianthopoulos, NC (1976): Congenital malformations in twins. Acta Genet Med Gemellol 25:331–335.Google Scholar
36.Oldfield, RC (1971): The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 9:97–113.Google Scholar
37.Prohovnik, D, Hakansson, K, Risberg, J (1980): Observations on the functional significance of regional cerebral blood flow in “resting” normal subjects. Neuropsychologia 18:203–217.CrossRefGoogle ScholarPubMed
38.Rife, DC (1940): Handedness, with special reference to twins. Genetics 25:178.CrossRefGoogle ScholarPubMed
39.Satz, P, Achenbach, K, Fennell, E (1967): Correlations between assessed manual laterality and predicted speech laterality in a normal population. Neuropsychologia 5:295–310.Google Scholar
40.Satz, P (1973): Lefthandedness and early brain insult: An explanation. Neuropsychologia 11:115–117.Google Scholar
41.Satz, P (1979): A test of some models of hemispheric speech organization in the left- and right-handed. Science 203:1131–1133.Google Scholar
42.Satz, P (1980): Incidence of aphasia in left-handers: A test of some hypothetical models of cerebral speech organization. In Herron, J (ed): “Neuropsychology of Lefthandedness.” New York: Academic press, pp 189–198.Google Scholar
43.Smith, C (1970): Heritability of liability and concordance in monozygous twins. Ann Hum Genet 34:85–91. (1972): Correlation in liability among relatives and concordance in twins. Hum Hered 22:97-101.Google Scholar
44.Smith, C (1974): Concordance in twins: Methods and interpretation. Am J Hum Genet 26:454–466.Google Scholar
45.Springer, S, Searleman, A (1980): Left-handedness in twins: Implications for the mechanisms underlying cerebral asymmetry of function. In Herron, J (ed): “Neuropsychology of Lefthandedness.” New York: Academic Press. (There are some minor inconsistencies in their Table 4.1).Google Scholar
46.Stern, C (1973): “Principles of Human Genetics.” San Francisco: W. H. Freeman, pp 408–410.Google Scholar