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NOR Variability in Twins

Published online by Cambridge University Press:  01 August 2014

R. Weltens ,
M. Kirsch-Volders ,
L. Hens ,
E. Defrise-Gussenhoven  and
C. Susanne
R. Weltens
Affiliation:
Laboratory of Anthropogenetics, Free University of Brussels
M. Kirsch-Volders*
Affiliation:
Laboratory of Anthropogenetics, Free University of Brussels
L. Hens
Affiliation:
Laboratory of Anthropogenetics, Free University of Brussels
E. Defrise-Gussenhoven
Affiliation:
Center of Biomathematics, Free University of Brussels
C. Susanne
Affiliation:
Laboratory of Anthropogenetics, Free University of Brussels Center of Biomathematics, Free University of Brussels
*
Lab, Antropogenetika, Vrije Universiteit, Pleinlaan 2, 1050 Brussels, Belgium

Abstract

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The number of AgNOR (NOR+) and the amount of AgNOR (NORM+) were analysed by means of two multilevel analyses of variance in a total of 12 twin pairs: 3 female and 4 male MZ and 5 male DZ pairs. In the first analysis, only zygosity was controlled; in the second, chromosome types D and G were controlled as well as the interaction between chromosome type and zygosity. For NOR+ and NORM+, when chromosome types D and G are not distinguished, the within-pair variance is greater, though not significantly, in DZ than in MZ pairs; but it is highly significantly greater when chromosome type (D or G type) is under control. This confirms an important genetic determination of NOR+ and NORM+ when in the ANOVA model the D and G types are controlled. However, nongenetic factors also influence the Ag-NOR patterns, but not enough to conceal the genetically defined rDNA pattern. Indeed, about 50% of the cells transcribe their rDNA in a way not closely dependent on the rDNA background and significant intrapair differences of NOR+ pattern exist in MZ twins.

Keywords

TwinsNOR stainingAnalysis of varianceD and G group chromosomes
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 34 , Issue 3-4 , October 1985 , pp. 141 - 151
Copyright
Copyright © The International Society for Twin Studies 1985

References

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