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Neurofibromatosis in Monozygotic Twins: A Case Report

Published online by Cambridge University Press:  01 August 2014

Hans Olof Åkesson ,
Rolf Axelsson  and
Birgitta Samuelsson
Hans Olof Åkesson*
Affiliation:
University of Göteborg, Sweden
Rolf Axelsson
Affiliation:
University of Göteborg, Sweden
Birgitta Samuelsson
Affiliation:
University of Göteborg, Sweden
*
Psychiatric Department III, Lillhagen Hospital, 422 03 Hisings Backa, Sweden

Abstract

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A case report is given of a pair of monozygotic twin girls with neurofibromatosis caused by a new mutation. The symptomatology was dominated by a neurofibrosarcoma on the leg of one twin and by a large plexiform neurofibroma on the neck of the other twin. Otherwise, the disease showed similar, although not identical or mirror-image distribution of subcutaneous neurofibromas and café-au-lait spots. The twins had identical HLA and blood group antigens and the same chromosome aberration. These case reports indicate that nonhereditary factors may influence the manifestations of neurofibromatosis. A review of the literature on monozygotic twins with neurofibromatosis is given.

Keywords

Neurofibromatosisv. Recklinghausen diseaseMonozygotic twins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 32 , Issue 3-4 , July 1983 , pp. 245 - 249
Copyright
Copyright © The International Society for Twin Studies 1983

References

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