Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-25T02:14:14.493Z Has data issue: false hasContentIssue false
  • English
  • Français

Multiple Births and Congenital Anomalies in Tokyo Metropolitan Hospitals, 1979-1990

Published online by Cambridge University Press:  01 August 2014

K. Kato  and
K. Fujiki
K. Kato
Affiliation:
Department of Neurology, Tokyo Metropolitan Institute for Neuroscience
K. Fujiki*
Affiliation:
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
*
Department of Ophthalmology, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113, Japan

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The rate of multiple births and the incidence of congenital anomalies in Tokyo Metropolitan Hospitals were studied during the period 1979-1990. The number of twins was 968 pairs (8.23 per 1,000 deliveries) and of triplets 18 sets (15.3 per 100,000 deliveries) among 117,672 deliveries including 1,587 stillbirths after 16 weeks gestation. Multiple birth rates increased yearly. Stillbirth rates in twins and triplets were 5.5% and 16.7% respectively, which were both significantly higher than that in singletons (1.3%). The number of congenital anomalies was 42 in 1,936 twins (2.17%), 2 in 54 triplets (3.7%) and 1721 in 116,686 singletons (1.47%). The most common defects in twins were those of the cardiovascular system (0.72% in twins vs 0.52% in singletons) and of the musculoskeletal system (0.72% in twins vs 0.50% in singletons), followed by upper respiratory tract and/or mouth conditions (0.67% in twins vs 0.35% in singletons), all of which had no significant difference in frequency between twins and singletons. Though some anomalies had a significantly higher frequency in twins than in singletons, the concordance rate in the like-sexed twins was very low.

Keywords

Multiple birthCongenital anomalyBirth defect monitoringHospital base
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 41 , Issue 4 , October 1992 , pp. 253 - 259
Copyright
Copyright © The International Society for Twin Studies 1992

References

REFERENCES

1. Hay, S, Wehrung, DA (1970): Congenital malformations in twins. Am J Hum Genet 22:662–678.Google Scholar
2. Imaizumi, Y (1987): The recent trends in multiple births and stillbirth rates in Japan. Acta Genet Med Gemellol 36:325–334.Google Scholar
3. Imaizumi, Y (1992a): The rising number of multiple pregnancies in Japan and other nations. Fertility, Sterility and Contraception. Vol. 1. Lancs: Parphenon Publishing.Google Scholar
4. Imaizumi, Y (1992b): Twinning rates in Japan, 1951-1990. Acta Genet Med Gemellol 41: 165–175.Google Scholar
5. Kato, K, Yokochi, M, Yoshimura, K, Fujiki, K, Kurosu, T, Shimomura, M (1990): Birth defects monitoring in Tokyo Metropolitan Hospitals, 10 years report, 1979-1988 (in Japanese) pp 1–149.Google Scholar
6. Layde, PM, Erickson, JD, Falek, A, McCarthy, BJ (1980): 4 Congenital malformations in twins. Am J Hum Genet 32:69–78.Google Scholar
7. Myrianthopoulos, NC (1978): Congenital malformations. Birth Defects XIV, No 6A, National Foundation pp 151–165.Google ScholarPubMed