Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-25T01:18:54.307Z Has data issue: false hasContentIssue false
  • English
  • Français

Monozygotic Twins with Concordance for Down's Syndrome and Congenital Heart Disease

Published online by Cambridge University Press:  01 August 2014

Z. Papp
Z. Papp*
Affiliation:
Human Genetics Laboratory, Department of Obstetrics and Gynecology, University Medical School, Debrecen, Hungary
*
Human Genetics Laboratory, Department of Obstetrics and Gynecology, University Medical School, H-4012 Debrecen, Hungary

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Cytogenetic, clinical, and other findings are presented on a pair of same-sex, monochorial MZ twins concordant for both trisomy 21 and congenital heart disease.

The literature on Down's syndrome in twins and on congenital heart disease in twins is reviewed and the exceptional occurrence of concordant congenital heart disease in MZ twins is stressed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 24 , Issue 1-2 , January 1975 , pp. 41 - 46
Copyright
Copyright © The International Society for Twin Studies 1975

References

REFERENCES

Allen, G., Baroff, G.S. 1955 Mongoloid twins and their siblings. Acta Genet., 5: 294.Google Scholar
Berg, J.M., Kirman, B.H. 1960. The mentally defective twin. Br. Med. J., 1: 1911.Google Scholar
Campbell, M. 1961. Twins and congenital heart disease. Acta Genet. Med. Gemellol. (Roma), 10: 443.Google Scholar
Citterio, C. 1964. Idiozia mongoloide in uno solo di due gemelli monozigoti. Riv. Neurobiol., 10: 383.Google Scholar
Dekaban, A. 1965. Twins, probably monozygotic: one mongoloid with 48 chromosomes, the other normal. Cytogenetics, 4: 227.CrossRefGoogle ScholarPubMed
Forsyth, C.C., Uchida, J. 1951. Auricular septal defect in one of monozygotic twins. Arch. Dis. Child., 26: 582.Google Scholar
Friedman, A. 1955. Mongolism in twins. Am. J. Dis. Child., 90: 43.Google Scholar
Gordon, R.G., Roberts, J.A.F. 1938. Paraplegia and mongolism in twins. Arch. Dis Child., 13: 79.Google Scholar
Hay, S., Wehrung, D.A. 1970. Congenital malformations in twins. Am. J. Hum. Genet., 22: 662.Google Scholar
Hustinx, T.W.J., Eberle, P., Geerts, S.J., Ten Brink, J., Woltring, L.M. 1961. Mongoloid twins with 48 chromosomes (AA + A21XXY). Ann. Hum. Genet., 25: 111.CrossRefGoogle ScholarPubMed
Jervis, G.A. 1943. Mongolism in twins. Am. J. Ment. Defic., 47: 364.Google Scholar
Keay, A.J. 1958. The significance of twins in mongolism in the light of new evidence. J. Ment. Defic. Res., 2: 1.Google Scholar
Kiossoglou, K.A., Rosenbaum, E., Mitus, W.J., Dameshek, W. 1963. Multiple chromosome aberrations in Down's syndrome associated with twinning and acute granulocytic leukaemia. Lancet, 2: 944.CrossRefGoogle ScholarPubMed
Lamy, M., De Grouchy, J., Schweisguth, O. 1957. Genetic and nongenetic factors in the etiology of congenital heart disease: a study of 1188 cases. Am. J. Hum Genet., 9: 17.Google Scholar
Lejeune, J., Lafourcade, J., Schrärer, K., De Wolff, E., Salmon, C., Haines, M.M., Turpin, R. 1962. Monozygotisme heterocaryote, jumeau normal et jumeau trisomique 21. Compt. Rend. 254: 4404.Google Scholar
Lipovetskaia, N.G. 1964. A case of Down's disease in both uniovular twins. Pediatrics, 43: 102.Google ScholarPubMed
Massimo, L., Gemme, G., Vianello, M.G., Verri, E. 1966. Studio di una coppia di gemelli dizigotici di cui una mongoloide con trisomia 21, e l'altro normale con chimerismo transitorio di cellule con trisomia 21. Acta Genet. Med. Gemellol. (Roma), 15: 208.Google Scholar
MacKaye, L. 1936. Mongolism in nonidentical twins. Am. J. Dis. Child., 52: 141.Google Scholar
McDonald, A.D. 1964. Mongolism in twins. J. Med. Genet., 1: 39.Google Scholar
Morison, J.E. 1959. Congenital malformations in one of monozygotic twins. Arch. Dis Child., 24: 214.Google Scholar
Nicholson, D.N., Keay, A.J. 1959. Mongolism in both twins of opposite sex. Arch. Dis. Child., 32: 325.Google Scholar
Nielsen, J. 1967. Inheritance in monozygotic twins. Lancet, 2: 717.Google Scholar
Nora, J.J., Gilliland, J.C., Sommerville, R.J., McNamara, D.G. 1967. Congenital heart disease in twins. N. Engl. J. Med., 277: 568.Google Scholar
Oster, J. 1953. Mongolism. Copenhagen: Danish Science Press.Google Scholar
Papp, Z., Gardó, S. 1970. Cytogenetic analysis of cord-blood lymphocytes. Lancet, 1: 1401.Google Scholar
Price, B. 1950. Primary biases in twin studies. Am. J. Hum. Genet., 2: 293.Google Scholar
Rasore-Quartino, A. 1967. Gemelli MZ con mongolismo concordante. Acta Genet. Med. Gemellol. (Roma), 16: 395.Google Scholar
Richards, B.W. 1969. Mosaic mongolism. J. Ment. Defic. Res., 13: 66.Google ScholarPubMed
Richards, B.W. 1971. The incidence of mongol twins. J. Ment. Defic. Res., 15: 121.Google Scholar
Rowe, R.D., Uchida, J.A. 1961. Cardiac malformation in mongolism: a prospective study of 184 mongoloid children. Am. J. Med., 31: 726.Google Scholar
Shapiro, L.R., Farnsworth, P.G. 1972. Down's syndrome in twins. Clin. Genet., 3: 364.Google Scholar
Shiono, H., Kasahara, S. Toyoguchi, A., Watanabe, N., Fugita, S., Yamaguchi, M, 1971. Genetic studies on twins of Down's syndrome with 47-chromosomes. Tohoku J. Exp. Med., 105: 309.Google Scholar
Smith, A. 1955. A note on mongolism in twins. Br. J. Prev. Soc. Med., 9: 212.Google ScholarPubMed
Telfer, M.A., Baker, D., Bergman, M. 1972. Twins, probably monozygotic, displaying Down's syndrome, physical and functional mirror-imaging and disordance for congenital heart disease, Am. J. Ment. Defic., 76: 391.Google Scholar
Turpin, R., Thoyer-Rozat, J., Lafourcade, J., Lejeune, J., Caille, B., Kesseler, A. 1964. Coincidence de mongolisme et de syndrome de Klinefelter chez l'un et l'autre jumlaux d'une paire monozygote. Pediatrie, 19: 43.Google Scholar
Turpin, R. 1964. Gémellités monozygotes et aberrations chromosomiques (monozygotisme hétérocaryote). Arch. Biol. (Liège), 75: 329.Google Scholar
Turpin, R. 1970. Monozygotisme hétérocaryote. Acta Genet. Med. Gemellol. (Roma), 19: 188.Google Scholar
Uchida, I.A., Rowe, R.D. 1957. Discordant heart anomalies in twins. Am. J. Hum. Genet., 9: 133.Google Scholar
Uchida, J.A., Soltan, H.C. 1963. Evaluation of dermatoglyphics in medical genetics. Pediatr. Clin. North Am., 10: 409.CrossRefGoogle Scholar
Weitz, W. 1936. Die Vererbung innerer Krankheiten. Stuttgart.Google Scholar
Wolff, de E., Schrärer, K., Lejeune, J. 1962. Contribution a l'étude des jumeaux mongoliens. Un cas de monozygotisme hétérocaryote. Helv. Paediatr. Acta 17: 301.Google Scholar
Wright, S.W., Day, R.W., Mosier, H.D., Koons, A., Mueller, H. 1963. Klinefelter's syndrome, Down's syndrome (mongolism), and twinning in the same sibship. Chromosomal studies in two families. J. Pediatr., 62: 217.Google Scholar
Zellweger, H. 1968. Familial aggregates of the 21-trisomy syndrome. Ann. N.Y. Acad. Sci., 155: 784.Google Scholar
Young, R.J. 1954. Mongolism in both of monozygotic twins. Arch. Dis. Child., 29: 55.Google Scholar