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Lower Frequency of Diabetes Among Hospitalized Negro than White Children: Theoretical Implications*

Published online by Cambridge University Press:  01 August 2014

Michael J. Mac Donald
Michael J. Mac Donald*
Affiliation:
Department of Medical Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
*
The Elliot P. Joslin Research Laboratory, Harvard Medical School, Boston, Massachusetts, USA

Abstract

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A review of the case histories of 471 diabetic children admitted to a children's hospital during the decade 1960 to 1970 showed that the proportion of diabetics among hospitalized Negro children was significantly lower than that among white children (3.8 Negro vs. 10.7 white per 1000 admissions same ethnic group, P < 0.005). However, the proportion of mild diabetes, characterized by absence of ketosis and no insulin requirement, was higher among Negro (18%) than among white diabetic children (0.5%). These differences could not be explained by differences in environmental factors considered. It is suggested that genetic factors may account for a substantial part of this Negro-white difference.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 24 , Issue 1-2 , January 1975 , pp. 119 - 126
Copyright
Copyright © The International Society for Twin Studies 1975

Footnotes

*

This work was supported in part by the Ranken-Jorden Foundation for the Crippling Diseases of Childhood and by USPHS Training Grant GM 1151. First submitted in November 1973.

References

REFERENCES

Dodu, S.R. 1958. The incidence of diabetes in Accra (Ghana). A study of 4,000 patients. West Afr. Med. J., 7: 129.Google Scholar
Dodu, S.R., de Heer, N. 1964. A diabetes case-finding survey in Ho, Ghana. Ghana Med. J., 3: 75.Google Scholar
Dodu, S.R., Harthorn, M.H. 1966. Diabetes in Accra. Ghana Med. J., 5: 2.Google Scholar
Garn, S.M., Sandusky, S.T., Nagy, J.M., McGann, M.B. 1972. Advanced skeletal development in low-income Negro children. J. Pediatr., 80: 965.Google Scholar
Glass, B., Li, C.C. 1953. The dynamics of racial intermixture: an analysis based on the American Negro. Am. J. Hum. Genet., 5: 1.Google Scholar
Goldberg, M.D., Marine, N., Ribeiro, F., Campbell, G.D., Vinik, A.I., Jackson, W.P.U. 1969. Prevalence of glycosuria and diabetes among Indians and Bantu. South Afr. Med. J., 43: 733.Google Scholar
Harvold, B. 1967. Genetic perspectives in diabetes mellitus. Acta Med. Scand. (Suppl.), 476: 17.Google Scholar
Jackson, W.P.U. 1970. In Camerini-Davalos, R.A. and Cole, H.S. (eds.): Early Diabetes. Advances in Metabolic Disorders, Supplement 1, p. 330.Google Scholar
Jackson, W.P.U., Huskisson, J.M. 1965. Diabetes: inter-racial comparisons 1. South Afr. Med. J., 39: 526.Google Scholar
Marine, N., Vinik, A.I., Edelstein, I., Jackson, W.P.U. 1969. Diabetes, hyperglycemia, and glycosuria among Indians, Malays and Africans (Bantu) in Cape Town, South Africa. Diabetes, 18: 840.Google Scholar
Michelson, N. 1944. Studies in the physical development of Negroes. IV: Onset of puberty. Am. J. Phys. Anthropol., 2: 151.Google Scholar
Osuntokun, B.O., Akinkugbe, F.M., Francis, T.I., Reddy, S., Osuntokun, O., Taylor, G.O.L. 1971. Diabetes mellitus in Nigerians: a study of 832 patients. West Afr. Med. J., 20: 295.Google Scholar
Reed, T.E. 1969. Caucasian genes in American Negroes. Science, 165: 762.Google Scholar
Rosenbaum, P. 1967. Juvenile diabetes at Charity Hospital. J. La. State Med. Soc., 119: 389.Google Scholar
Sankale, M., Wade, F. 1966. Le diabète Sucré en milieu hospitalier dakarois (à propos de 260 cas). Bull. Soc. Med. Afr. Noire Lang. Fr., 11: 730.Google Scholar
Seftel, H.C. 1964. Diabetes in the Johannesburg African. Leech, 34: 82.Google Scholar
U.S. Bureau of the census 1971. Census of the Population: 1970. General Population Characteristics, Final Report PC(1)-B34, New York, Table 34. Washington, D.C.: U.S. Government Printing Office.Google Scholar
U.S. Public Health Service 1967. Characteristics of persons with diabetes. In: Vital and Health Statistics, p. 15. Washington, D.C.: U.S. Government Printing Office (PHS Publication No. 1000, Series 10, No. 40).Google Scholar
U.S. Public Health Service 1969. Diabetes Source Book, pp. 10–11. Washington, D.C.: U.S. Government Printing Office (PHS Publication No. 1168).Google Scholar
Verghese, K.P., Scott, R.B., Teixeira, G., Ferguson, A.D. 1969. Studies in growth and development. XII. Physical growth of North American Negro children. Pediatrics, 44: 243.Google Scholar
Ziegra, S.R. 1969. Personal communication.Google Scholar