Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-24T08:07:05.175Z Has data issue: false hasContentIssue false
  • English
  • Français

Intrapair Differences of Physical Aging and Longevity in Identical Twins

Published online by Cambridge University Press:  01 August 2014

K. Hayakawa ,
T. Shimizu ,
Y. Ohba ,
S. Tomioka ,
S. Takahasi ,
K. Amano ,
A. Yura ,
Y. Yokoyama  and
Y. Hayakata
K. Hayakawa*
Affiliation:
Departments of Public Health, Osaka, Japan
T. Shimizu
Affiliation:
Departments of Public Health, Osaka, Japan
Y. Ohba
Affiliation:
Departments of Clinical Pathology, Osaka, Japan
S. Tomioka
Affiliation:
Departments of Central Clinical Laboratory, Kinki University School of Medicine, Osaka, Japan
S. Takahasi
Affiliation:
Department of First Internal Medicine, Fukushima Medical College, Fukushima, Japan
K. Amano
Affiliation:
Fukushima Biomedical Institute of Environmental and Neoplastic disease, Fukushima, Japan
A. Yura
Affiliation:
Departments of Public Health, Osaka, Japan
Y. Yokoyama
Affiliation:
College of Medical Technology, Osaka University, Osaka, Japan
Y. Hayakata
Affiliation:
Departments of Public Health, Osaka, Japan
*
Department of Public Health, Kinki University, School of Medicine, 377-Ohno-Higashi, Osaka-Sayama, Osaka 589, Japan

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The genetic and environmental contributions to physical aging (hair graying, balding, presbyopia) and longevity (age at death) were examined by within-pair comparison in monozygotic (MZ) and dizygotic (DZ) twins in later adulthood. Physical aging was investigated on 135 pairs of adult twins aged over 50. Hair graying and hair loss (baldness) showed significantly higher rates of concordance in the MZ twins than in the DZ twins. The intrapair difference of the degree of hair graying was negligible in 79%, slight in 15% and striking in 5% among the MZ pairs; while negligible in 40%, slight in 50% and striking in 10% among the DZ pairs. The intrapair difference of the degree of hair loss was negligible in 92%, slight in 8% (and striking in none) among the MZ pairs; while negligible in 69%, slight in 25% and striking in 6% among the DZ pairs. The age at onset of presbyopia showed a slightly higher rate of concordance in the MZ than in the DZ pairs. Longevity (age at death) was surveyed on 184 pairs of twins who died at over 40 years of age. The intrapair difference of longevity was 6.65 ± 5.6 years (maximum 18.0; minimum 0.04) in the MZ pairs, and 8.66 ± 7.2 years (maximum 18.6; minimum 2.9) in the DZ pairs. The MZ pairs showed a slightly smaller within-pair difference of longevity than the DZ pairs.

Keywords

Physical agingLongevityTwinsEnvironmentGenetic factors
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 41 , Issue 2-3 , July 1992 , pp. 177 - 185
Copyright
Copyright © The International Society for Twin Studies 1992

References

REFERENCES

1. Cederlof, R et al (1966): Respiratory symptoms and “Angina Pectoris” in twins with reference to smoking habits. Arch Environ Health 13:727–748.Google Scholar
2. Cederlof, R et al (1967): Hereditary factors and angina pectoris. Arch Environ Health 14:397–400.Google ScholarPubMed
3. Faire, UD et al (1975): Concordance for mortality with special reference to ischaemic heart disease and cerebrovascular disease. Prev Med 4:509–517.Google Scholar
4. Feinleib, M et al (1977): The NHLBI twin study of cardiovascular disease risk factors; methodology and summary of results. Am J Epidem 106:284–295.Google Scholar
5. Fisher, quoted by Ishikawa, E (1979): New Statistics. Tokyo: Maki Publishing.Google Scholar
6. Harvald, B et al (1963): Heredity of cancer elucidated by a study of unselected twins. JAMA 186:749–753.Google Scholar
7. Harvald, B et al (1970); Coronary occlusion in twins. Acta Genet Med Gemellol 19:248–250.Google Scholar
8. Hayakawa, K et al (1982): Health survey on aging twins. Jpn J Public Health 39:279–285.Google Scholar
9. Hayakawa, K, Shimizu, T, Ohba, Y, Tomioka, S (1987): Lifestyle factors affecting intrapair differences of serum apoproteins and cholesterol concentrations in adult twins. Athersclerosis 66:1–9.Google Scholar
10. Hayakawa, K, Shimizu, T (1987): Blood pressure discordance and lifestyle: Japanese identical twins reared apart and together. Acta Genet Med Gemellol 36:485–491.Google ScholarPubMed
11. Hayakawa, K (1987): Smoking and drinking discordance and health conditions: Japanese identical twins reared apart and together. Acta Genet Med Gemellol 36:493–501.Google ScholarPubMed
12. Hayakawa, K (1988): Gemellological study on genetic and environmental factors affecting serum concentrations of lipids and electrolytes in adult twins. Jpn J Hygien 43:763–777.Google Scholar
13. Hayflick, L et al (1961): The serial cultivation of human diploid cell strains. Exp Cell Res 25:585–621.CrossRefGoogle ScholarPubMed
14. Hayflick, L (1965): The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37:614–636.Google Scholar
15. Jablon, S et al (1967); The NAS-NRC twin panel. Am J Hum Genet 19:133–161.Google ScholarPubMed
16. Jarvik, LF et al (1960): Survival trends in senescent twin population. Am J Hum Genet 12:170–179.Google Scholar
17. Jarvik, LF et al (1971): Organic brain syndrome and chromosome loss in aged twins. Dis Nerv Syst 32:159–170.Google Scholar
18. Kallmann, FJ et al (1948): Twin studies on aging and longevity. J Hered 39:349–357.Google Scholar
19. Kallmann, FJ, Sounder, G (1949): Twin studies on senescence. Am J Psychiatry 106:29–36.Google Scholar
20. Kallmann, FJ (1950): The genetics of psychoses: an analysis of 1,232 twin index families. VI Congress International de Psychiatrie, Genetique et Eugenique: Hermann & Cie, pp. 1–27.Google Scholar
21. Kallmann, FJ, Feingold, L, Bondy, E (1951): Comparative adaptational social and psychometric data and the life histories of senescent twin pairs. Am J Human Genet 3:69–73.Google Scholar
22. Nielsen, A et al (1957): Twin studies in the Danish cancer registry 1942-55. Br J Cancer 11:327–336.Google Scholar
23. Shimizu, S (1959): Twin study on aging phenomenon (I). Jpn J Anat 34:729–771.Google Scholar
24. Shimizu, S (1960): Twin study on aging phenomenon (II). Jpn J Anat 35:12–14.Google Scholar
25. Snedecor, GW and Cochran, W (1967); Statistical Methods (6th ed). Iowa State Univ Press.Google Scholar
26. Stern, C (1973): Principles of human genetics (3rd ed). San Francisco: WH Freeman and Co, pp. 635–684.Google Scholar
27. Sugawara, O et al (1990): Induction of cellular senescence in immortalized cells by human chromosome 1, Science 247:707–710.Google Scholar