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Immunohistochemical Analysis of c-Fos and c-Jun in Retinoblastoma

Published online by Cambridge University Press:  01 August 2014

F. Faraldi ,
A. Calzolari ,
M. Forni ,
F.L. Chiarelli Mincione  and
G. Alfieri
F. Faraldi*
Affiliation:
Istituto di Clinica Oculistica e
A. Calzolari
Affiliation:
Istituto di Anatomia e Istologia Patologica dell'Università degli Studi di Firenze, Firenze, Italy
M. Forni
Affiliation:
Divisione di Anatomia Patologica - Ospedale Regina Margherita, Torino, Italy
F.L. Chiarelli Mincione
Affiliation:
Istituto di Clinica Oculistica e
G. Alfieri
Affiliation:
Istituto di Clinica Oculistica e
*
Clinica Oculistica II, Viale Morgagni 85, I-50141 Firenze, Italy

Abstract

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The c-fos promoter is negatively regulated by the retinoblastoma (Rb)-suceptibility-gene- encoded protein as well as by other genes involved in the control of transcription, cell cycle regulation and neoplastic transformation. We have examined by immunohistochemistry the c-Fos and c-Jun proteins in five cases of retinoblastoma in order to evaluate eventual alterations in their expression in vivo, possibly related to a gene mutation or to loss of Rb negative control.

Keywords

RetinoblastomaHumanImmunohistochemistryC-FosC-Jun
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 45 , Issue 1-2 , April 1996 , pp. 289 - 291
Copyright
Copyright © The International Society for Twin Studies 1996

References

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