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Identical Twins Discordant for Congenital Spinal Anomalies

Published online by Cambridge University Press:  01 August 2014

J. François ,
M. Th. Matton-Van Leuven ,
M. Vercauteren ,
D. Vandenbulcke-Donck  and
S. De Bie
J. François*
Affiliation:
Genetics Laboratory, Departments of Ophthalmology and Orthopedics, University of Ghent, Belgium
M. Th. Matton-Van Leuven
Affiliation:
Genetics Laboratory, Departments of Ophthalmology and Orthopedics, University of Ghent, Belgium
M. Vercauteren
Affiliation:
Genetics Laboratory, Departments of Ophthalmology and Orthopedics, University of Ghent, Belgium
D. Vandenbulcke-Donck
Affiliation:
Genetics Laboratory, Departments of Ophthalmology and Orthopedics, University of Ghent, Belgium
S. De Bie
Affiliation:
Genetics Laboratory, Departments of Ophthalmology and Orthopedics, University of Ghent, Belgium
*
Ophthalmological Clinic, University Hospital, De Pintelaan 135, 9000 Ghent, Belgium

Summary

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A twin pair, discordant for congenital spinal cervical anomalies, is described. Zygosity chances are calculated on the basis of initial dizygosity chance, sex likeness, red cell antigens, serum types, red cell enzymes, and dermatoglyphic data. The chance for monozygosity adds up to 0.9992. Literature data on cervical anomalies in twins are reviewed.

It is concluded that, although the inheritance of spinal anomalies, such as hemivertebra, is still an open question, this twin pair supports the present trend of ideas that most of these anomalies are caused by peripheral, nongenetic factors.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 21 , Issue 1-2 , April 1972 , pp. 107 - 115
Copyright
Copyright © The International Society for Twin Studies 1972

References

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