Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-19T08:38:14.623Z Has data issue: false hasContentIssue false
  • English
  • Français

Human Placental Lactogen and dU-Estrogen Levels in Normal Twin Pregnancies

Published online by Cambridge University Press:  01 August 2014

B. Kappel ,
K. Hansen ,
J. Moller  and
J. Faaborg-Andersen
B. Kappel*
Affiliation:
Department of Obstetrics and Gynecology, Kommunehospital, Aarhus, Denmark
K. Hansen
Affiliation:
Department of Obstetrics and Gynecology, Kommunehospital, Aarhus, Denmark
J. Moller
Affiliation:
Department of Obstetrics and Gynecology, Kommunehospital, Aarhus, Denmark
J. Faaborg-Andersen
Affiliation:
Department of Obstetrics and Gynecology, Kommunehospital, Aarhus, Denmark
*
Cytogenetic Laboratory, Aarhus Psychiatric Hospital, DK-8240 Risskov, Denmark

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Reference intervals for human placental lactogen (hPL) and dU-estrogens (dU-E) in uncomplicated twin pregnancies are found to be higher than singleton pregnancies and considerably wider. Significantly more monozygotic than dizygotic pregnancies, and significantly more monoplacental than diplacental pregnancies showed hPL values below the median on the normal range curve. The same was not found for dU-E. Significantly more growth-retarded fetuses were found in monoplacental than diplacental pregnancies. The benefit of measuring the two parameters in order to identify the intrauterine growth retarded fetuses were evaluated in terms of sensitivity and specificity. Both parameters were found less suitable for the purpose.

Keywords

Twin pregnancyHormone reference intervalsHuman placental lactogendU-estrogensIntrauterine growth retardation
Type
Review Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 34 , Issue 1-2 , April 1985 , pp. 59 - 65
Copyright
Copyright © The International Society for Twin Studies 1985

References

REFERENCES

1. Batra, S, Sjöberg, NO, Aaberg, A (1978): Human placental lactogen, estradiol-17β, and progesterone levels in the third trimester and their respective values for detecting twin pregnancy. Am J Obstet Gynecol 131:69–72.Google Scholar
2. Braunstein, GD, Karow, WG, Gentry, WC, Rasor, J, Wade, ME (1978): Third trimester chorionic gonadotropin measurements as an aid in the diagnosis of early pregnancy disorders. Am J Obstet Gynecol 131:25–32.Google Scholar
3. Briët, JW, Horn, RKJ (1982): The use of human placental lactogen, oxytocinase and estriol in twin pregnancies with intrauterine growth retardation. Eur J Obstet Gynecol Reprod Biol 13:7–14.CrossRefGoogle ScholarPubMed
4. Crane, JP, Kopta, MM (1979): Prediction of intrauterine growth retardation with ultrasonically measured head/abdominal circumference ratios. Obstet Gynecol 54:597,603.Google Scholar
5. Daw, E (1977): Human placental lactogen and twin pregnancy. Lancet 2:299–300.CrossRefGoogle ScholarPubMed
6. Divers, WA, Hamsell, DL (1979): The use of ultrasound in multiple gestations. Obstet Gynecol 53:500–504.Google Scholar
7. Duff, GB, Brown, JB (1977): Urinary oestriol excretion in twin pregnancies. J Obstet Gynecol Br Commonw 81:695–700.Google Scholar
8. Gennser, G, Grennert, L, Kullander, S, Persson, PH, Wingerup, L (1975): Human placental lactogen in screening ofr multiple pregnancies. Lancet 1:274.CrossRefGoogle Scholar
9. Gerhard, I, Runnebaum, B (1980): Hormonbestimmungen bei Mehrlingsschwangerschaften. Geburtsh Frauenheilk 40:101–115.CrossRefGoogle Scholar
10. Grennert, L, Gennser, G, Persson, PH, Kullander, S (1976): Ultrasound and human-placental lactogen screening for early detection of twin pregnancies. Lancet 1:4–6.Google Scholar
11. Kappel, B, Brogaard Hansen, K, Møller, J, Faaborg-Andersen, J (1984): Gemelligraviditet. Obstetriske og neonatale problemer. Ugerskr Laeg 146:3448–3452.Google Scholar
12. Lever, H, Powell, JC, Peace, SM (1973): Improved estriol determination on a continous flow system. Biochem Med 8:188–191.Google Scholar
13. Reed, AH, Henry, RJ, Mason, WB (1971): Influence of Statistical method used on the resulting estimate of the normal range. Clin Chem 17:275–284.CrossRefGoogle Scholar
14. Svenstrup, B (1976): Radioimmunologisk bestemmelse as frit ϕstriol i serum under graviditet. Ugeskr Laeg 183:1075–1077.Google Scholar
15. Ylikorkala, O (1973): Maternal serum hPL levels in normal and complicated pregnancy as an index of placental function. Acta Obstet Gynecol Scand (Suppl) 26:1–52.Google Scholar