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Holzinger's HC Revised

Published online by Cambridge University Press:  01 August 2014

Gordon Allen
Gordon Allen*
Affiliation:
Division of Biometry and Epidemiology, National Institute of Mental Health, US Department of Health, Education and Welfare, Rockville, Maryland
*
NIMH, 5600 Fishers Lane, Rockville, MD 20857, USA

Abstract

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The formula H′C = 1 − CDZ/CMZ is suggested as a better summary of twin concordance data than the familiar Holzinger concordance formula, HC = (CMZ − CDZ)/ (1 − CDZ). The new formula better estimates degree of genetic determination, G, as calculated from a threshold model, but never exceeds unity, as G sometimes does. For high concordance rates, if CMZ + CDZ > 1, HC, may be more useful than either G or H′C.

Keywords

Heritability estimatesTwin concordance
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 28 , Issue 2 , April 1979 , pp. 161 - 164
Copyright
Copyright © The International Society for Twin Studies 1979

References

REFERENCES

1.Holzinger, KJ (1929): The relative effect of nature and nurture on twin differences. J Educ Psychol 20:241–248.CrossRefGoogle Scholar
2.Smith, C (1974): Concordance in twins: Methods and interpretation. Am J Hum Genet 26:454–466.Google Scholar