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Heritability of Systolic Blood Pressure. Analysis of Variance in MZ Twin Parents and Their Children

Published online by Cambridge University Press:  01 August 2014

R. J. Rose ,
D. W. Fulker ,
J. Z. Miller ,
C. E. Grim  and
J. C. Christian
R. J. Rose*
Affiliation:
Department of Psychology, Indiana University, Bloomington
D. W. Fulker*
Affiliation:
Institute of Psychiatry, University of London
J. Z. Miller
Affiliation:
Department of Psychology, Indiana University, Bloomington
C. E. Grim
Affiliation:
Department of Medicine
J. C. Christian
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis
*
Department of Psychology, Indiana University, Bloomington IN 47405
Institute of Psychiatry, Bethlem Royal Hospital, Beckenham BR 3 3BX, UK

Abstract

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Systolic blood pressure, standardized for age and sex, was measured in 76 MZ twin pairs and their 341 children. Maximum likelihood estimation of genetical and environmental parameters from the independent parental and offspring ANOVAs indicated a complete absence of both maternal and shared environmental effects, together with a heritability of 63%. These results are shown to be reasonably consistent with those from previous studies.

Keywords

Systolic blood pressureMaximum likelihood genetic analysisTwin model
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 29 , Issue 2 , April 1980 , pp. 143 - 149
Copyright
Copyright © The International Society for Twin Studies 1980

References

REFERENCES

1.Biron, P, Mongeau, J-G, Bertrand, D (1976. Familial aggregation of blood pressure in 558 adopted children. Can Med Assoc J 115:773–774.Google Scholar
2.Borhani, NO, Feinleib, M, Garrison, RJet al (1976. Genetic variance in blood pressure. Acta Genet Med Gemellol 25:137–144.Google Scholar
3.Feinleib, M (1977): Genetics and Familial Aggregation of Blood Pressure. Presented at Fifth Hahneman International Symposium on Hypertension. San Juan, Puerto Rico.Google Scholar
4.Feinleib, M, Garrison, RJ, Fabsitz, R, Christian, JCet al (1977. The NHLBI Twin Study of Cardiovascular Disease Risk Factors: Methodology and summary of results. Am J Epidemiol 106:284–295.CrossRefGoogle ScholarPubMed
5.Fulker, DW (1978): Multivariate extensions of a biometrical model of twin data. In Nance, WE, Allen, G, Parisi, P (eds): “Twin Research: Psychology and Methodology.” New York: Alan R. Liss, pp 217–236.Google Scholar
6.Havlik, RJ, Garrison, RJ, Katz, SH, Elison, RCet al (1979. Detection of genetic variance in blood pressure of seven-year old twins. Am J Epidemiol 109:512–516.CrossRefGoogle ScholarPubMed
7.Higgins, M, Cole, P, Gam, S, Keller, J (1977): Familial resemblance in blood pressure. “CVD Epidemiology Newsletter” (Council on Epidemiology, American Heart Association). No. 22.Google Scholar
8.Jinks, J, Fulker, DW (1970): Comparison of the biometrical genetical, MAVA, and classical approaches to the analysis of human behavior. Psychol Bull, 73:311–349.Google Scholar
9.Mcllhany, ML, Shaffer, JW, Hines, EA Jr (1975. The heritability of blood pressure: An investigation of 200 pairs of twins using the cold pressor test. Johns Hopkins Med J 136:57–64.Google Scholar
10.Miall, WE, Heneage, P, Khosla, T, Lovell, HG, Moore, F (1967. Factors influencing the degree of resemblance in arterial pressure of close relatives. Clin Sci 33:271–283.Google ScholarPubMed
11.Nance, WE, Corey, LA (1976): Genetic models for the analysis of data from the families of identical twins. Genetics 83:811–826.CrossRefGoogle ScholarPubMed
12.Rao, DC, Morton, NE, Yee, S (1974. Analysis of family resemblance. II. A linear model for familial correlation. Am J Hum Genet 26:331–359.Google Scholar
13.Rose, RJ, Miller, JZ, Grim, CE, Christian, JC (1979. Aggregation of blood pressure in the families of identical twins. Am J Epidemiol 109:503–511.Google Scholar
14.Sackett, DL (1975): Studies of blood pressure in spouses. In Paul, O (ed): “Epidemiology and Control of Hypertension.” New York: Stratton Intercontidental Medical Book Corp, pp 21–38.Google Scholar
15.Sokal, RR, Rohlf, FJ (1969): “Biometry.” San Francisco: Freeman.Google Scholar
16.Zinner, SH, Martin, LF, Sackes, Fet al (1974. A longitudinal study of blood pressure in childhood. Am J Epidemiol 100:437–442.Google Scholar