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Guidelines for the Prevention of Multiple Pregnancy in Treatment by in Vitro Fertilization

Published online by Cambridge University Press:  01 August 2014

F. Leroy ,
F. Puissant ,
P. Barlow  and
G. de Maertelaer
F. Leroy*
Affiliation:
IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Belgium
F. Puissant
Affiliation:
IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Belgium
P. Barlow
Affiliation:
IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Belgium
G. de Maertelaer
Affiliation:
IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Belgium
*
Department of Obstetrics and Gynecology, Saint Pierre Hospital, Rue Haute 322, B-1000 Brussels, Belgium

Abstract

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Within the same in vitro fertilization (IVF) program, treatment trials leading to single and multiple ongoing gestation were compared. Rates of cesarean delivery, prematurity and perinatal mortality were found much higher among twin and multiple IVF pregnancies. Our work thus attempts at defining characteristics of proneness to multiple gestation in IVF treatment, in order to try and avoid its occurrence. The mean vitality score of embryos replaced is the most reliable criterion for this purpose, enabling one to replace no more than two embryos when the average score is high. Age of the patient and cause of infertility are almost nondiscriminant in this respect. Ovarian stimulation parameters such as total dosage of gonadotropin treatment and level of estrogenic response, as well as numbers of oocytes and embryos obtained, may serve as secondary criteria for assessing the twinning risk.

Keywords

In vitro fertilizationOvarian stimulationEmbryosTwinning risk
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 3 , July 1990 , pp. 371 - 378
Copyright
Copyright © The International Society for Twin Studies 1990

References

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