Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-25T01:28:51.706Z Has data issue: false hasContentIssue false
  • English
  • Français

A Genetic Study of Rheumatic Fever Clustering in Families1

Published online by Cambridge University Press:  01 August 2014

Merton S. Honeyman  and
Eli Davis
Merton S. Honeyman*
Affiliation:
Connecticut State Department of Health, Hartford, Connecticut
Eli Davis
Affiliation:
Hadassah Medical Organization, Jerusalem
*
Connecticut Twin Registry, State Department of Health, 79 Elm Street, Hartford, Connecticut 06115, USA

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The first-degree relations of 433 rheumatic propositi were examined for evidence of rheumatic fever (RF) or rheumatic heart disease (RHD). The families of 470 control propositi were examined in identical fashion. Of the total propositi, 378 propositi were matched with 378 control propositi for sex, age group, and ethnic community (European or Afro-Asian origin). Of 738 sibs of rheumatic propositi, 19.6% had RF or RHD and of 586 sibs of controls, 3.1% had RF or RHD (P<0.001).

In the matched families 2,985 first-degree relations of the propositi were examined: 142 had RF and 141 had RHD, a total of 9.5%. In the members of the families of the rheumatic propositi 232 rheumatics were found in 1,486 first-degree relations (15.6%), while in the control families 51 rheumatics were found among 1,499 (3.4%).

Comparisons and analyses were made of expected and observed numbers according to sibship size using the method of truncated analyses (Lenz-Hogben method). This analysis supported the hypothesis of a simple mendelian recessive inheritance. Unbiased estimates of P, the population frequency of affected individuals, were consistent with the value P = 0.25, expected for a mendelian recessive character. The rheumatic fever clustering in families in this study was compatible with a simple recessive mendelian inheritance.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 20 , Issue 2 , April 1971 , pp. 189 - 198
Copyright
Copyright © The International Society for Twin Studies 1970

Footnotes

1

This study was supported by research grant no. BSS CD IS3 from the U.S. Public Health Service.

References

American Heart Association (1965). Ad Hoc Committee to Revise the Jones' Criteria (modified) of the Council on Rheumatic Fever and Congenital Heart Disease. Jones criteria (revised) for guidance in the diagnosis of rheumatic fever. Circulation, 32: 664.Google Scholar
Davies, A.M., Lazarov, E. (1960). Heredity, infection and chemoprophylaxis in rheumatic carditis: an epidemiological study of a communal settlement. J. Hyg. (Camb.), 58: 263.CrossRefGoogle ScholarPubMed
Davis, E. (1969). Rheumatic Fever. Clinical, Ecological and Familial Aspects. Charles C. Thomas, Springfield.Google Scholar
Diamond, E.F. (1957). Hereditary and environmental factors in the pathogenesis of rheumatic fever. Pediatrics, 19: 908.CrossRefGoogle ScholarPubMed
Diamond, E.F. (1962). Is there a rheumatic constitution? J. Pediat., 54: 341.CrossRefGoogle Scholar
Gart, J.J. (1967). A simple nearly efficient alternative to the simple sib method in the complete ascertainment case. Ann. Hum. Genet., 31: 283.CrossRefGoogle Scholar
Gray, F.G., Quinn, W., Quinn, J.P. (1952). A long term survey of rheumatic and non-rheumatic families with particular reference to environment and heredity. Amer. J. Med., 13: 400.CrossRefGoogle ScholarPubMed
Harvald, B., Hauge, M. (1965). Hereditary factors elucidated by twin studies. In: Neel, J. V., Shaw, M. W., Schull, W.J.: Genetics and the Epidemiology of Chronic Diseases. Public Health Service Publication No.1163.Google Scholar
Honeyman, M.S. (1968). Unpublished data. Lecture Hebrew University, Hadassah Medical School.Google Scholar
Li, C.C. (1961). Human Genetics. McGraw-Hill Book Co., New York.Google Scholar
O'Brien, W.M. (1968). Twin studies in rheumatic diseases. Arthritis Rheum., 11: 81.CrossRefGoogle ScholarPubMed
Reed, S. (1964). Parenthood and Heredity. John Wiley & Sons, Inc., New York.Google Scholar
Stevenson, A. C., Cheeseman, E.A. (1953). Heredity and rheumatic fever. A study of 462 families ascertained by an affected child and 51 families ascertained by an affected mother. Ann. Eugen., 17: 177.CrossRefGoogle ScholarPubMed
Stevenson, A.C., Cheeseman, E.A. (1956). Heredity and rheumatic fever. Some later information about data collected in 1950-55. Ann. Hum. Genet., 21: 139.CrossRefGoogle Scholar
Taranta, A., Torosdag, S., Metrakos, J.D., Jegier, W., Uchida, I.A. (1959). Rheumatic fever in monozygotic and dizygotic twins. Circulation, 20: 778.Google Scholar
Taranta, A., Torosdag, S,, Metrakos, J.D., Jegier, W., Uchida, I.A. (1961). Rheumatic fever in monozygotic and dizygotic twins. Proc. Int. Congr. Rheumatic Diseases, Rome. Minerva Med., 2: 1–4.Google Scholar
Uchida, I.A. (1953). Possible genetic factors in etiology of rheumatic fever. Amer. J. Hum. Genet., 5: 61.Google ScholarPubMed
Wilson, M.G. (1940). Rheumatic Fever. The Commonwealth Fund, New York.Google Scholar
Wilson, M.G., Schweitzer, M. (1954). Pattern of hereditary susceptibility in rheumatic fever. Circulation, 10: 699.CrossRefGoogle ScholarPubMed
Wilson, M.G. (1962). Advances in Rheumatic Fever 1940-1961. Hoeber Med. Div., Harper & Row, New York.Google Scholar