Article contents
Genetic Models of Affective Disorder: Application to Twin Data
Published online by Cambridge University Press: 01 August 2014
Abstract
Twin data on bipolar and unipolar affective disorders are analyzed by multiple threshold models of inheritance. The two illness types are represented in the models on a continuum of genetic–environmental liability in which bipolar illness has a higher liability threshold than unipolar disorder. Autosomal single major locus model provides an acceptable fit to observed concordance rates in monozygotic twins. The multifactorial-polygenic model is rejected.
- Type
- Research Article
- Information
- Acta geneticae medicae et gemellologiae: twin research , Volume 29 , Issue 4 , October 1980 , pp. 289 - 294
- Copyright
- Copyright © The International Society for Twin Studies 1980
References
REFERENCES
- 4
- Cited by