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A Genetic Analysis of Taste Threshold for Phenylthiocarbamide

Published online by Cambridge University Press:  01 August 2014

C. C. Morton ,
R. M. Cantor ,
L. A. Corey  and
W. E. Nance
C. C. Morton
Affiliation:
Department of Human Genetics, Medical College of Virginia, Richmond
R. M. Cantor
Affiliation:
Department of Human Genetics, Medical College of Virginia, Richmond
L. A. Corey*
Affiliation:
Department of Human Genetics, Medical College of Virginia, Richmond
W. E. Nance
Affiliation:
Department of Human Genetics, Medical College of Virginia, Richmond
*
Department of Human Genetics, MCV Station, Box 33, Richmond, VA 23298, USA

Abstract

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Taste threshold for phenylthiocarbamide (PTC) was measured in 393 offspring from the families of 85 monozygotic (MZ) twin pairs. PTC scores were bimodally distributed with modes at one and eight and the antimode at five. Because of the non-normality of the distribution, a jackknife procedure was used to obtain 95% confidence intervals for the estimates of genetic, maternal, and environmental parameters. Analyses which assumed no epistasis and which included additive genetic effects revealed that 37.9% of the observed variation in PTC threshold was due to additive genetic effects, 16.6% was due to dominance effects, 14.2% was due to maternal effects, 13.7% was due to a common sibship environment, and 17.6% was due to random environmental effects, yielding a broad sense heritability of 0.55 for the threshold ability to taste PTC. Analyses which did not include additive genetic effects revealed 26.6% of the observed variance was due to dominance effects, 23.6% to maternal effects, and 49.8% to environmental effects at the 0.67 confidence levels, but that environmental factors accounted for 72.4% and dominance effects for 23.6% of the observed variation at the 95% level.

Keywords

Phenylthiocarbamide (PTC)Twin modelJackknife procedurePolygenic trait
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 30 , Issue 1 , January 1981 , pp. 51 - 57
Copyright
Copyright © The International Society for Twin Studies 1981

References

REFERENCES

1.Arvensen, JN, Schmitz, TH (1970): Robust procedures for variance component problems using the jackknife. Biometrics 26:677–686.CrossRefGoogle Scholar
2.Blakeslee, AF (1932): Genetics of sensory thresholds: Taste for phenylthiocarbamide. Proc Natl Acad Sci USA 18:120–130.CrossRefGoogle Scholar
3.Blakeslee, AF, Salmon, MR (1931): Odor and taste blindness. Eugen News 16:105–108.Google Scholar
4.Fox, AL (1931): Six in ten “tasteblind” to bitter chemical. Sci News Lett, Wash 19:249.Google Scholar
5.Harris, H, Kalmus, H (1949): The measurement of taste sensitivity to phenylthiourea (P.T.C.). Ann Eugen 15:24–31.CrossRefGoogle Scholar
6.Levine, P, Anderson, AS (1932): Observations on taste blindness. Science 75:497–498.Google Scholar
7.Merton, BB (1958): Taste sensitivity to PTC in 60 Norwegian families with 176 children. Confirmation of the hypothesis of single gene inheritance. Acta Genet 8:114–128.Google Scholar
8.Mochizuki, Y (1939): Papilla foliata of Japanese. Folia Anat Japon 18:337–369.Google Scholar
9.Mohr, J (1951): Taste deficiency to phenylthiourea in Denmark. Ann Eugen, Lond 16:282–286.Google Scholar
10.Nance, WE, Corey, LA (1976): Genetic models for the analysis of data from the families of identical twins. Genetics 83:811–826.Google Scholar
11.Parr, LW (1934): Taste blindness and race. J Hered 25:187–190.Google Scholar
12.Snyder, LH (1931): Inherited taste deficiency. Science 14:151.Google Scholar
13.Snyder, LH (1932): The inheritance of taste deficiency in man. Ohio J Sci 32:436–440.Google Scholar
14.Wallace, DC, Blanc, H, Giles, RE, Case, JT, Cann, HM (1980): Maternal inheritance of human mitochondrial DNA restriction endonuclease polymorphisms. Am J Hum Genet 32:10A.Google Scholar