Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-25T02:43:20.028Z Has data issue: false hasContentIssue false
  • English
  • Français

G-6-PD Deficiency and Abnormal Hemoglobins in a Brazilian Population

Published online by Cambridge University Press:  01 August 2014

F. M. Salzano ,
F. Lewgoy ,
C. V. Tondo  and
F. J. da Rocha
F. M. Salzano*
Affiliation:
Departamento de Genética, Instituto de Ciências Naturais, Universidade Federal do Rio Grande do Sul, Pôrto Alegre (Brazil)
F. Lewgoy*
Affiliation:
Departamento de Genética, Instituto de Ciências Naturais, Universidade Federal do Rio Grande do Sul, Pôrto Alegre (Brazil)
C. V. Tondo*
Affiliation:
Departamento de Genética, Instituto de Ciências Naturais, Universidade Federal do Rio Grande do Sul, Pôrto Alegre (Brazil)
F. J. da Rocha*
Affiliation:
Departamento de Genética, Instituto de Ciências Naturais, Universidade Federal do Rio Grande do Sul, Pôrto Alegre (Brazil)
*
Departamento de Genética, Instituto de Ciências Naturais, Universidade Federal do Rio Grande do Sul, Pôrto Alegre, Brazil
Departamento de Genética, Instituto de Ciências Naturais, Universidade Federal do Rio Grande do Sul, Pôrto Alegre, Brazil
Departamento de Genética, Instituto de Ciências Naturais, Universidade Federal do Rio Grande do Sul, Pôrto Alegre, Brazil
Departamento de Genética, Instituto de Ciências Naturais, Universidade Federal do Rio Grande do Sul, Pôrto Alegre, Brazil

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Data are reported about the occurrence of glucose-6-phosphate dehydrogenase deficiency (G-6-PDD) and abnormal hemoglobins in a sample (316 males and 679 females) of the Negroid population of Porto Alegre, Brazil. The prevalence of double carriers (AS/G-6-PDD) was that expected from the isolated incidence of both anomalies. A review of the literature shows similar results for 3491 males and 289 females from African and American Negroid groups both from areas with and without malaria. Therefore there seem to exist no grounds for postulating an adaptive interaction between these two polymorphisms.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 4 , October 1968 , pp. 607 - 612
Copyright
Copyright © The International Society for Twin Studies 1968

References

Gilles, H. M., Hendrickse, R. G., Lindner, R., Reddy, S., Allan, N. (1967). G-6-PD deficiency, sickling, and malaria in African children in South Western Nigeria. Lancet, 1: 138–140.CrossRefGoogle Scholar
Kraus, A. P., Neely, C. L., Carey, F. T., Kraus, L. M. (1962). Detection of deficient erythrocyte regeneration of reduced triphosphopyridine nucleotide from glucose-6-phosphate. Evaluation of a rapid screening test. Ann. Intern. Med., 56: 765–773.Google Scholar
Lewgoy, F., Salzano, F. M. (1967). G-6-PD deficiency gene dynamics in a Brazilian population. A.Ge.Me.Ge. (In press).Google Scholar
Lewis, R. A., Hathorn, M. (1965). Correlation of S hemoglobin with G-6-PD deficiency and its significance. Blood, 26: 176–180.CrossRefGoogle Scholar
Lewis, R. A., Kay, R. W., Hathorn, M. (1966). Sickle cell disease and G-6-PD. Acta Haemat., 36: 399–411.CrossRefGoogle Scholar
Livingstone, F. B. (1964). Aspects of the population dynamics of the abnormal hemoglobin and G-6-PD deficiency genes. Amer. J. Hum. Genet., 16: 435–450.Google Scholar
Marti, H. R., Schoepf, K., Gsell, O. R. (1965). Frequency of haemoglobin S and G-6-PD deficiency in Southern Tanzania. Brit. Med. J., 1: 1476–1477.CrossRefGoogle Scholar
Motulsky, A. G. (1964). Hereditary red cell traits and malaria. Amer. J. Trop. Med. Hyg., 13: 147–158.CrossRefGoogle ScholarPubMed
Motulsky, A. G. Vandepitte, J., Fraser, G. R. (1966). Population genetics studies in Congo. I. G-6-PD deficiency, hemoglobin S, and malaria. Amer. J. Hum. Genet., 18: 514–537.Google Scholar
Naylor, J., Rosenthal, I., Grossman, A., Schulman, I., Hsia, D. Y. (1960). Activity of G-6-PD in erythrocytes of patients with various abnormal hemoglobins. Pediatrics, 26: 285–292.CrossRefGoogle Scholar
Pik, C., Loos, J., Jonxis, J. H. P., Prins, H. K. (1965). Hereditary and acquired blood factors in the Negroid population of Surinam. II. The incidence of haemoglobin anomalies and the deficiency of G-6-PD. Trop. Geogr. Med., 1: 61–68.Google Scholar
Tondo, C. V., Salzano, F. M. (1960). Hemoglobin types of the Caingang Indians of Brazil. Science, 132: 1893–1894.CrossRefGoogle ScholarPubMed
Tondo, C. V., Salzano, F. M. (1962). Abnormal hemoglobins in a Brazilian Negro population. Amer. J. Hum. Genet., 14: 401–409.Google Scholar
Van der Sar, A., Schouten, H., Struyker Boudier, A. M. (1964). G-6-PD deficiency in red cells. Incidence in the Curaçao population, its clinical and genetic aspects. Enzymologia, 27: 289–310.Google Scholar