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Published online by Cambridge University Press: 01 August 2014
Chemotherapy of murine Rauscher virus-induced leukemia using Trenimon, 6-Mercaptopurine, 5-Fluorouracil and Melphalan is described. Therapy is based on nucleated cell counts in peripheral blood and body weight of the animals. Remarkable remissions of the number of nucleated cells — not occurring in untreated animals — are induced by Trenimon and 6-Mercaptopurine. Prolongation of survival times exceeds 100% in the groups treated with Trenimon, 6-Mercaptopurine, and 5-Fluorouracil.