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Excessive Follicular Recruitment and Growth in Mothers of Spontaneous Dizygotic Twins

Published online by Cambridge University Press:  01 August 2014

N.G. Martin ,
S. Shanley ,
K. Butt ,
J. Osborne  and
G. O'Brien
N.G. Martin*
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
S. Shanley
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
K. Butt
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
J. Osborne
Affiliation:
Department of Radiology, Royal Women's Hospital, Brisbane, Australia
G. O'Brien
Affiliation:
Department of Radiology, Royal Women's Hospital, Brisbane, Australia
*
Queensland Institute of Medical Research, Brisbane, Qld 4029, Australia.

Abstract

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We wished to establish the frequency, regularity and laterality of multiple ovulation in mothers of dizygotic (DZ) twins and controls. Subjects had regular menses and were not using oral contraceptives. Ovarian ultrasound scans were taken over a number of cycles in 21 mothers of DZ twins and 18 controls (including 13 mothers of monozygotic [MZ] twins). Multiple large follicles (≥ 12 mm diameter) were seen significantly more frequently in mothers of DZ twins (13/21 mothers, 24/77 cycles, average ± SE follicles/cycle 1.34 ± 0.11) than controls (2/18 mothers, 3/31 cycles, average 1.10±0.08). Both ipsilateral and contralateral multiple follicles were observed. In one case a mother of DZ twins showed multiple large follicles in 7 out of 10 cycles in which she was scanned, including both ipsi-and contralateral patterns of occurrence.

Keywords

Dizygotic twinningMultiple ovulationFollicular developmentOvarian ultrasound
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 40 , Issue 3-4 , October 1991 , pp. 291 - 301
Copyright
Copyright © The International Society for Twin Studies 1991

References

REFERENCES

1. Bomsel-Helmreich, O (1985): Ultrasound and the preovulatory human follicle. In Clarke, J.R. (ed): Oxford Reviews of Reproductive Biology. London: Clarendon Press, pp. 1–72.Google Scholar
2. Bulmer, MG (1970): The Biology of Twinning in Man. Oxford: Oxford University Press.Google Scholar
3. Check, JH, Dietterich, C, Houck, MA (1991): Ipsilateral versus contralateral ovary selection of dominant follicle in succeeding cycle. Obstet Gynecol 77: 247 CrossRefGoogle ScholarPubMed
4. Chen, P, Hayward, NK, Kidson, C, Ellem, KAO (1990): Conditions for generating well- resolved human DNA fingerprints using M13 phage DNA. Nucleic Acids Res 18:1065.CrossRefGoogle ScholarPubMed
5. Corney, G, Seedburgh, D, Thompson, B, Campbell, DM, MacGillivray, I, Timlin, D (1981): Multiple and singleton pregnancy: differences between mothers as well as offspring. In Gedda, L, Parisi, P, Nance, W: Twin Research 3: Twin Biology and Multiple Pregnancy. New York: AR Liss Inc, pp 107–114.Google Scholar
6. Gougeon, A, Lefevre, B (1983): Evolution of the diameters of the largest healthy and atretic follicles during the human menstrual cycle. J Reprod Fert 69:497–502.CrossRefGoogle ScholarPubMed
7. Gougeon, A, Lefevre, B (1984): Histological evidence of alternating ovulation in women. J Reprod Fert 70:7–13.CrossRefGoogle ScholarPubMed
8. Haukioja, E, Lemmetyinen, R, Pikkola, M (1989): Why are twins so rare in Homo sapiens? Amer Nat 133:572–577.CrossRefGoogle Scholar
9. Hodgen, GD (1986): Ovarian function for multiple follicle maturation. Clin Obstet Gynaecol 29:127–140.CrossRefGoogle ScholarPubMed
10. Khoury, MJ, Erickson, JD (1983): Maternal factors in dizygotic twinning: Evidence from interracial crosses. Ann Hum Biol 10:409–416.CrossRefGoogle ScholarPubMed
11. Marinho, AO, Sallam, HN, Goessens, L, Collins, WP, Campbell, S (1982): Ovulation side and occurrence of mittelschmerz in spontaneous and induced ovarian cycles. Br Med J 284:632.Google Scholar
12. Martin, NG, Martin, PG (1975): The inheritance of scholastic abilities in a sample of twins I. Ascertainment of the sample and diagnosis of zygosity. Ann Hum Genet 39:213–218.CrossRefGoogle Scholar
13. Martin, NG, Robertson, DM, Chenevix-Trench, G, de Kretser, DM, Osborne, J, Burger, HG (1991): Elevation of follicular phase inhibin and luteinizing hormone levels in mothers of dizygotic twins suggests non-ovarian control of human multiple ovulation. Fertil Steril 56:469–474.CrossRefGoogle Scholar
14. Martin, NG, Olsen, ME, Thiele, H, El Beaini, JL, Handelsman, D, Bhatnagar, AS (1984): Pituitary-ovarian function in mothers who have had two sets of DZ twins. Fertil Steril 41:878–880.CrossRefGoogle Scholar
15. Mather, K (1973): The Genetical Structure of Populations. London: Chapman and Hall.Google Scholar
16. Nilsson, L, Wikland, M, Hamberger, L (1982): Recruitment of an ovulatory follicle in the human following follicle-ectomy and luteectomy. Fertil Steril 37:30–34.CrossRefGoogle ScholarPubMed
17. O'Herlihy, C, de Crespigny, LJ, Robertson, HP (1980): Monitoring ovarian follicular development with real-time ultrasound. Br J Obstet Gynaecol 87:613–618.CrossRefGoogle ScholarPubMed
18. Parisi, P, Gatti, M, Prinzi, G, Caperna, G (1983): Familial incidence of twinning. Nature 304:626–8.CrossRefGoogle ScholarPubMed
19. Philippe, P (1985): Genetic epidemiology of twinning: A population-based study. Am J Med Genet 20:97–105.CrossRefGoogle ScholarPubMed
20. Philippe, P, Roy, R (1989): Conceptive delays of twin-prone mothers: A demographic epidemiologic approach. Hum Biol 61:599–614.Google ScholarPubMed
21. Potashnik, G, Insler, V, Meizner, I, Sternberg, M (1987): Frequency, sequence and side of ovulation in women menstruating normally. Br Med J 294:219.CrossRefGoogle ScholarPubMed
22. Queenan, JT, O'Brien, GD, Bains, LM, Simpson, J, Collins, WP, Campbell, S (1980): Ultrasound scanning of ovaries to detect ovulation in women. Fertil Steril 34:99–105.CrossRefGoogle ScholarPubMed
23. Tonetta, SA, di Zerega, GS (1986): Paracrine regulation of follicular maturation in primates. Clin Endocrinol Metab 15:135–156.CrossRefGoogle ScholarPubMed
24. Wallach, EE, Virutamasen, P, Wright, KH (1973): Menstrual cycle characteristics and side of ovulation in the rhesus monkey. Fertil Steril 24:715–721.CrossRefGoogle ScholarPubMed