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Estimates of Genetic and Environmental Components of Serum Isocitrate Dehydrogenase (ICDH) in Normal Twins

Published online by Cambridge University Press:  01 August 2014

D. Rapaport ,
G.M.D.D. Colletto ,
M. Vainzof  and
M. Zatz
D. Rapaport
Affiliation:
Department of Biology, Bioscience Institute, University of Sao Paulo, Brazil
G.M.D.D. Colletto
Affiliation:
Informatics and Data Analysis Division, Biomedical Science Institute, University of Sao Paulo, Brazil
M. Vainzof
Affiliation:
Department of Biology, Bioscience Institute, University of Sao Paulo, Brazil
M. Zatz*
Affiliation:
Department of Biology, Bioscience Institute, University of Sao Paulo, Brazil
*
Departamento de Biologia, Universidade de São Paulo, Caixa Postal 11461, São Paulo, SP, Brazil

Abstract

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Environmental (b2) and genetic heritability (h2) of serum isocitrate dehydrogenase (ICDH) were estimated in 96 pairs of healthy twins according to a path analysis model. The results showed significant heritability (0.42) and a very low environmental component (based on obesity and level of habitual physical activity), suggesting that these factors do not influence ICDH serum activity.

Keywords

Isocitrate dehydrogenaseObesityHeritabilityTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 40 , Issue 1 , January 1991 , pp. 77 - 82
Copyright
Copyright © The International Society for Twin Studies 1991

References

REFERENCES

1.Bowers, GN (1959): Measurement of isocitric dehydrogenease activity in body fluids. Clin Chim 5:509–509.CrossRefGoogle Scholar
2.Christian, JC, Norton, JA Jr (1977): A proposed test of the difference between the means of monozygotic and dizygotic twins. Acta Genet Med Gemellol 26:49–53.CrossRefGoogle ScholarPubMed
3.Colletto, GMDD, Kolya, M, Zimberknopf, S (1987): Diagnosis of twin zygosity by dermatoglyphic index. Rev Brasil Genet 2:289–299.Google Scholar
4.Colletto, GMDD, Krieger, H. Magalhaes, JR (1981): Estimates of the genetical and environmental determinants of serum lipid and lipoprotein concentration in Brazilian twins. Hum Hered 31:232–237.CrossRefGoogle Scholar
5.Colletto, GMDD, Krieger, H, Magalhaes, JR (1983): Genetic and environmental determinants of 17 serum biochemical traits in Brazilian twins. Acta Genet Med Gemellol 32:23–29.Google Scholar
6.Garn, SM, Baily, SM and Higgens, ITT (1980): Effects of socio-economic status, family line and living together on fatness and obesity. In Lauer, RM and Shekelle, RB (eds): Childhood Prevention of Atherosclerosis and Hypertension. New York: Raven Press.Google Scholar
7.Heller, R, Garrison, RJ, Havlik, RJ, Feinleib, M, Padgett, S (1984): Family resemblances in height and relative weight in the Framingham Heart Study. Int J Obesity 8:399–405.Google ScholarPubMed
8.King, J (1974): Thesis, Institute of Medical Laboratory Technology, London, 1967. In Bergmey, (ed): Methods of Enzymatic Analysis, vol. 2, 2nd English Ed. New York: Academic Press.Google Scholar
9.Nicholson, GA, Morgan, GJ, Merrkin, M, Strauss, ER, MacLeod, JG (1986): The effect of aerobic exercise on seven creatine kinase activities. Muscle & Nerve 9:820–824.Google Scholar
10.O'Conell, DL, Heller, RF, Roberts, DCK, Allen, JR, Knapp, JC, Steele, PL, Silove, D (1988): Twin study of genetic and environmental effects on lipid levels. Genet Epidemiol 5:323–341.Google Scholar
11.Passos-Bueno, MR, Otto, PA and Zatz, M (1989): Estimates of conditional heterozygosity risks for young females in Duchenne muscular dystrophy. Hum Hered 39:202–211.Google Scholar
12.Passos-Bueno, MR, Rabbi-Bortolini, E, Azevedo, E, Zatz, M (1989): Racial effect on serum creatine-kinase: implication for estimation of heterozygosity risks for females at-risk for Duchenne dystrophy. Clin Chim Acta 179:163–168.Google Scholar
13.Percy, ME, Andrews, DF, Thompson, MW (1982): Serum creatine kinase in the Duchenne muscular dystrophy carriers: effects of season and multiple testing. Muscle & Nerve 5:58–64.Google Scholar
14.Rao, DC, Morton, NE, Yee, S (1976): Analysis of family resemblance II. A model for familial correlation. Am J Hum Genet 28:228–242.Google Scholar
15.Rao, DC, Morton, NE, Gulbrandsen, CL, Rhoads, GG, Kajan, A, Yee, S (1979): Cultural and biological determinants of lipoprotein concentration. Ann Hum Genet 42:467–477.Google Scholar
16.Rao, DC, Laskarzewshi, PM, Morrison, JA (1982): The Cincinnati Lipid Research Clinic Family Study: Cultural and biological determinants of lipids and lipoprotein concentrations. Am J Hum Genet 34:888–903.Google ScholarPubMed
17.Rapaport, D, Colletto, GMDD, Zatz, M (1988): Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: Implication for genetic risks estimates in Duchenne muscular dystrophy carriers. Am J Med Genet 31:291–298.Google Scholar
18.Sigma Technical Bulletin (1978): Isocitrate Dehydrogenase (ICDH). Catalog 176.Google Scholar
19.Sterkel, RL, Spencer, JA, Wolfon, SK Jr, Willians-Ashman, HG (1958): Serum isocitric dehydrogenase activity with particular reference to liver disease. J Lab Clin Med 52:176–184.Google Scholar
20.Stunkard, AJ, Foch, TT, Hrubec, Z (1986): A twin study of human obesity. JAMA 256:51–54.Google Scholar
21.Wong, ET, Colob, C, Umehara, MK, Wolff, GA, Haywood, J, Theodore, G, Shaw, ST (1983): Heterogeneity of serum creatine kinase activity among racial and gender groups of the population. Am J Pathol 79:582–586.Google Scholar
22.Zatz, M, Passos, MR, Bortolini, ER (1983): Serum pyruvate-kinase (PK) activity during pregnancy in potential carriers for Duchenne muscular dystrophy. Am J Med Genet 15:149–151.Google Scholar