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Erythrocytary Glucose-6-Phosphate Dehydrogenase Deficiency – Study on its distribution in the province of Ferrara and its relation to malaria and thalassemia

Published online by Cambridge University Press:  01 August 2014

E. Gandini ,
C. Menini ,
A. De Filippis  and
G. Dell'Acqua
E. Gandini*
Affiliation:
Istituto di Genetica Medica dell'Università, Ferrara
C. Menini*
Affiliation:
Istituto di Genetica Medica dell'Università, Ferrara
A. De Filippis*
Affiliation:
Istituto di Genetica Medica dell'Università, Ferrara
G. Dell'Acqua*
Affiliation:
Istituto di Genetica Medica dell'Università, Ferrara
*
Istituto di Genetica Medica dell'Università, Ferrara, Italia
Arcispedale S. Anna, Centro Trasfusionale, Ferrara, Italia
Arcispedale S. Anna, Divisione Pediatrica Ospedaliera e Centro Studi della Microcitemia, Ferrara, Italia
Istituto di Genetica Medica dell'Università, Ferrara, Italia

Summary

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The distribution of G6PD-D in the Ferrara country has been studied by means of the Brilliant Cresyl Blue discoloration test: 2437 males have been tested in 11 localities.

The highest gene frequency of G6PD-D observed is consistent with the one expected after 25-30 generations of malaria selection, assuming an increased fitness of the heterozygotes, as it has been shown in computer simulated evolutionary trends for sex-linked genes. The thalassemia trait has also been shown to be very frequent in the same localities; its frequency is correlated with G6PD-D gene frequency and with the incidence of malaria in the past (1900).

G6PD-D frequency is not significantly correlated with malaria. Such a result is due to the significantly lower gene frequency of G6PD-D observed in the localities where the percentage of population affected by malaria was higher (40-60%). On the other hand, G6PD-D is frequently significantly correlated with malaria in the remaining localities where the incidence of the latter ranged from 0 to 35% of the affected population.

The mechanisms possibly involved in the determination of this distribution of G6PD-D are discussed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 18 , Issue 3 , July 1969 , pp. 271 - 284
Copyright
Copyright © The International Society for Twin Studies 1969

References

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