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The Ergon/Chronon System in Schizophrenia A Twin Study

Published online by Cambridge University Press:  01 August 2014

L. Braconi
L. Braconi*
Affiliation:
The Gregor Mendel Institute of Medical Genetics and Twin Studies, Rome
*
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Piazza Galeno 5, 00161 Roma, Italy

Summary

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Ten (eight MM and two FF) MZ twin pairs, with one or both schizophrenic members, have been examined. The disease was concordant in four pairs, discordant in one pair, and partly concordant in five pairs.

The time of onset was simultaneous in five pairs, but showed differences of three years in two pairs, and of one-two years in two more pairs. Concordance in the time of onset was not related to severity of the disease.

Riassunto

Riassunto

Sono state esaminate dieci coppie di gemelli MZ, di cui otto MM e due FF, con almeno un cogemello affetto da schizofrenia. La malattia è risultata concordante in quattro coppie, discordante in una e parzialmente concordante nelle altre cinque.

Il tempo d'insorgenza della malattia è risultato lo stesso in cinque coppie, mentre ha presentato una differenza di tre anni in due coppie e di uno-due anni in altre due. La concordanza nel tempo d'insorgenza non è apparsa in relazione alla gravità della forma.

Résumé

RÉSUMÉ

Dix couples de jumeaux MZ (huit MM et deux FF), avec au moins un membre atteint de schizophrénie, ont été examinés. La maladie s'est démontrée concordante chez quatre couples, discordante chez une, et partiellement concordante chez les autres cinq.

Le temps de début de la maladie a été le même chez cinq couples, mais a différé de trois ans chez deux couples et de un-deux ans chez deux autres. La concordance dans le temps de début n'est pas en rapport à la gravité de la forme.

Zusammenfassung

Zusammenfassung

Es wurden zehn EZ-Paare (acht ♂ u. zwei ♀) untersucht, bei denen wenigstens ein Paarling an Schizophrenie litt. Das Leiden erwies sich bei acht Paaren konkordant, bei einem Paar diskordant und bei den übrigen fünf Paaren teilweise konkordant.

Bei fünf Paaren war die Krankheit gleichzeitig aufgetreten; bei zwei Paaren betrug der Unterschied drei Jahre und bei den anderen beiden Paaren ein bis zwei Jahre. Es zeigte sich kein Zusammenhang zwischen der Konkordanz der Auftrittszeit und der Schwere des Leidens.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 20 , Issue 4 , October 1971 , pp. 373 - 379
Copyright
Copyright © The International Society for Twin Studies 1971

References

Bini, L., Bazzi, T. (1967). Trattato di Psichiatria. Ed. Vallardi, Milano.Google Scholar
Birch, H.G., Hertzig, M.E. (1967). Etiology of Schizophrenia. In J. Romano: Origins of Schizophrenia.Google Scholar
Böök, J.A. (1960). A genetic and neuropsychiatrie investigation of a North-Swedish population. Acta Genet. (Basel), 4: 1–133.Google Scholar
Gedda, L. (1951). Lo Studio dei Gemelli. Ed. Orizzonte Medico, Roma.Google Scholar
Gedda, L., Braconi, L. (1966). The twin method in the study of psychoses and psychoneuroses. Proc. 4th Mon. Cong. Psychiat., Madrid.Google Scholar
Gedda, L., Brenoi, G. (1969). Biology of the gene: the ergon/chronon system. Acta Genet. Med. Gemellol., 18: 329–379.Google Scholar
Gottesmann, I.I., Shields, J. (1966). Schizophrenia in twins. Br. J. Psychol., 112: 809.CrossRefGoogle Scholar
Gottesmann, I.I., Shields, J. (1967). A poligenic theory of schizophrenia. Proc. Nat. Acad. Sci. USA, 581: 199.CrossRefGoogle Scholar
Hanhart, E. (1965). Die Genetischen Problem der Schizophrenien. Acta Genet. Med. Gemellol., 14: 13–40.CrossRefGoogle Scholar
Kallmann, F.J. (1946). The genetic theory of schizophrenia. Am. J. Psychol., 103: 309.CrossRefGoogle ScholarPubMed
Kringlen, E. (1967). Heredity and Social Factors in Schizophrenic Twins. In Romano, J.: Origins of Schiz-ophrenia.Google Scholar
Johanson, E. (1958). A study of schizophrenia in the male. Acta Psychiatr. Scand. (Suppl. 125), 33.Google Scholar
Luxenburger, H. (1934). Die Manifestationswahrscheinlichtkeit der Schizophrenie in Lichte der Zwillings-forschung. Z. Psych. Hyg., 7: 174.Google Scholar
Mitsuda, H. (1967). Clinical Genetics in Psychiatry. Osaka.Google Scholar
Pollin, W., Stabenau, J.R., Mosher, L., Tupin, J. (1966). Life history differences in identical twins discord-ant for schizophrenia. Am. J. Orthopsychiatry, 36: 3.Google Scholar
Romano, J. (1967). The Origins of Schizophrenia. Excerpta Medica Foundation, Amsterdam.Google Scholar
Rosenthal, D. (1960). Confusion of identity and frequency of schizophrenia in twins. Acta Gener. Psych., 3: 297.Google Scholar
Rosenthal, D. (1967). An Hystorical and Methodological Review of Genetic Studies in Schizophrenia. In Romano, J.: Origins of Schizophrenia.Google Scholar
Slater, E. (1953). Psychotic and Neurotic Illnesses in Twins. Her Maj. Stat. Off., London.Google Scholar
Slater, E. (1958). A monogenic theory of schizophrenia. Acta Genet. (Basel), 1: 50.Google Scholar
Shultz, B. (1956). Zur Frage der Erblichkeit der Schizophrenie. Acta Genet. (Basel), 5: 51.Google Scholar
Tienari, P. (1963). Psychiatric illnesses in identical twins. Acta Psychiatr. Scand. (Suppl. 171), 39.Google Scholar
Zazzo, A. (1960). Les Jumeaux: le Couple et la Personne. Press Univ. France, Paris.Google Scholar