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Embryologic Development and Monozygotic Twinning

Published online by Cambridge University Press:  01 August 2014

J.G. Hall  and
E. Lopez-Rangel
J.G. Hall*
Affiliation:
Department of Pediatrics, University of British Columbia and Children's Hospital, Vancouver, Canada
E. Lopez-Rangel
Affiliation:
Department of Pediatrics, University of British Columbia and Children's Hospital, Vancouver, Canada
*
Department of Pediatrics, University of British Columbia and Children's Hospital, 4480 Oak Street Room 2D15, Vancouver, V6H 4V4, Canada

Extract

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In 1875, Sir Francis Galton was the first to propose that by comparing the concordance of a specific trait or disorder in monozygotic (MZ) twins (assumed to be genetically identical) and dizygotic (DZ) twins (which were assumed to be as similar or as different as any other pair of sibs), it would be possible to distinguish between environmental and heritable effects. DZ twins are derived from the fertilization of two eggs by two sperm. MZ twins are the result of the fertilization of one egg by one sperm that then divides to form two embryos.

Genetic research has made amazing progress since 1875. Advances in molecular DNA techniques and developmental genetics have made it possible to differentiate unequivocally between MZ and DZ twins [1, 14]. It is in this new light that this manuscript will review the recent knowledge about twins and the twinning process.

The incidence of DZ twins differs between population [11, 18]. A DZ twin birth in North America is estimated to occur 9–11 times in every 1000 live births or 1 in 100 births; i.e. 1 in every 50 people is a DZ twin.

The DZ twinning rate is closely related to maternal age, parity, height, weight and gonadotropin levels. An increased DZ twinning rate is seen with increasing maternal age and peaks around 35–39 years; higher parity is also associated with a higher DZ twinning rate [19]. Tall heavy women are more likely to give birth to DZ twins than short thin women. A higher incidence of DZ twins has also been reported with the use of new reproductive techniques.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 45 , Issue 1-2 , April 1996 , pp. 53 - 57
Copyright
Copyright © The International Society for Twin Studies 1996

References

REFERENCES

1. Akane, A, Matsubara, K, Shiono, H, Yamada, M, Nakagome, Y: Diagnosis of twins zygosity by hypervariable RFLP markers. Am J Med Genet 1991; 41: 96–98.Google Scholar
2. Bressers, WMA, Eriksson, AW, Kostense, PJ: Increasing trend in monozygotic twinning rate. Acta Genet Med Gemellol (Roma) 1987; 36: 397–399.Google Scholar
3. Boklage, CE: The organization of the oocyte and embryogenesis in twinning and fusion malformations. Acta Genet Med Gemellol (Roma) 1987; 36: 421–431.Google Scholar
4. Burn, J, Povey, S, Boyd, Y, Munro, EA, West, L, Harper, K, Thomas, D: Duchenne muscular dystrophy in one of monozygotic twin girls. J Med Genet 1986; 23: 494–500.Google Scholar
5. Czeizel, A, Metneki, J, Dudas, I: Higher rate of multiple births after periconceptual vitamin supplementation. Lancet 1994; 330: 23–24.Google Scholar
6. Doyle, PE, Beral, V, Botting, B, Wale, CJ: Congenital malformations in twins in England and Wales. J Epidemiol Community Health 1990; 45: 43–48.Google Scholar
7. Edwards, RG, Mettler, L, Walters, DE: Identical twins and in vitro fertilization. J In Vitro Fertil Embryo Transfer 1986; 3: 114–117.Google Scholar
8. Goodship, J, Carter, J, Speer, A, Burn, J: X-inactivation patterns in monozygotic and dizygotic female twins. Am J Med Genet, in press.Google Scholar
9. Harvey, MAS, Huntley, RMC, Smith, DW: Familial monozygotic twinning. J Pediatr 1977; 90: 246–250.Google Scholar
10. Hill, AVS, Jeffreys, AJ: Use of minisatellite DNA probes for determination of twin zygosity at birth. Lancet 1985; ii: 1394.Google Scholar
11. Imaizumi, Y: Triplets and higher order multiple births in Japan. Acta Genet Med Gemellol (Roma) 1990; 39: 295–306.Google Scholar
12. Jauniaux, E, Elkazen, N, Leroy, F: Clinical and morphologic aspects of the vanishing twin phenomenon. Obstet Gynecol 1986; 68: 577–581.Google Scholar
13. Jeanty, P, Rodesch, F, Verhoogen, C: The vanishing twin. Ultrasonics 1981; 2: 25–30.Google Scholar
14. Jeffreys, AJ, Wilson, V, Thein, SL: Individual specific “fingerprints” of human DNA. Nature 1985; 316: 76–77.Google Scholar
15. Kallen, B: Congenital malformations in twins: A population study. Acta Genet Med Gemellol (Roma) 1986; 33: 61–69.Google Scholar
16. Landy, HJ, Weiner, S, Corson, SL: The “vanishing twin”: Ultrasonographic assessment of fetal disappearance in the first trimester. Am J Obstet Gynecol 1986; 155: 14–20.Google Scholar
17. Machin, G, Still, K, Tasneem, L: Correlations of placental vascular anatomy and clinical outcomes in sixty-nine monochorionic twin pregnancies. Am J Med Genet, in press.Google Scholar
18. Nylander, PPS: Frequency of multiple births; in MacGillivray, I, Nylandert, PPS, Corney, G, (eds): Human Multiple Reproduction. London, Saunders, 1975, p 87.Google Scholar
19. Nylander, PPS: The factors that influence twinning rates. Acta Genet Med Gemellol (Roma) 1981; 30:189–202.Google Scholar
20. Parisi, P, Gatti, M, Prinzi, G, Caperna, G: Familial incidence of twinning. Nature 1983; 304: 626–628.CrossRefGoogle ScholarPubMed
21. Schinzel, AGL, Smith, DW, Miller, JR: Monozygotic twinning and structural defects. J Pediatr 1979; 95: 921–930.Google Scholar
22. Shapiro, LR, Zemek, L, Shulman, MJ: Familial monozygotic twinning: An autosomal dominant form of monozygotic twinning with variable penetrance; in: Twin Research: Biology and Epidemiology. New York, Liss, 1978; pp 61–98.Google Scholar
23. Stockard, CR: Developmental rate and structural expression: An experimental study of twins, double monsters and single deformities and the interaction among embryonic organs during their origin and development. Am J Anat 1921; 13: 115–277.Google Scholar
24. van Dijk, BA, Boomsma, DI, de Man, AJM: Blood group chimaerism in human multiples is not rare. Am J Med Genet, in press. Twin symposium. Am J Med Genet (in press).Google Scholar