Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-25T02:18:14.299Z Has data issue: false hasContentIssue false

Effects of Melphalan on a Sensitive and a Resistant Yoshida Ascites Tumour

Published online by Cambridge University Press:  01 August 2014

E. H. Cooper
Affiliation:
Chester Beatty Res. Inst., Institute of Cancer Research, Royal Cancer Hospital, London
Norma E. Topping
Affiliation:
Chester Beatty Res. Inst., Institute of Cancer Research, Royal Cancer Hospital, London

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The mode of action of the alkylating agent Melphalan on Yoshida ascites tumours resistant and sensitive to alkylating agents in rats has been studied. A combination of autoradiography and analytical histochemistry has been used to measure changes in the cell kinetics. The sensitive strain showed a marked fall in mitotic index, build up in G2 and finally interphase death occurring 24-72 hours after treatment. The resistant form showed only slight mitotic inhibition and a possible recovery phase 24-30 hours after treatment, without evidence of cytological damage.

Type
Research Article
Copyright
Copyright © The International Society for Twin Studies 1967

References

Balfour, B. M. et al. (1965). DNA metabolism of the immunoglobulin containing cells in the lymph nodes of rats. J. Reticuloendothel. Soc., 2: 379.Google Scholar
Ball, C. R. et al. (1966). Comparison of nitrogen mustard sensitive and resistant Yoshida sarcomas. Int. J. Cancer, 1: 319.CrossRefGoogle ScholarPubMed
Deeley, E. M. (1955). An integrating microdensitometer for biological cells. J. Sci. Instrum., 32: 263.CrossRefGoogle Scholar
Hale, A. J. (1963). The leucocyte as a possible exception to the theory of DNA constancy. J. Path. Bad., 85: 311.Google Scholar
Halpern, B. N. et al. (1953). Quantitative study of granulopectic activity of reticuloendothelial system. I-The effect of the ingredients present in India ink and of substances affecting blood clotting in vivo on fate of carbon particles administered intravenously in rats, mice and rabbits. Brit. J. Exp. Path., 34: 426.Google Scholar
Quastler, H., Sherman, F. G. (1959). Cell population kinetics in intestinal epithelium of the mouse. Exp. Cell Res., 17: 420.CrossRefGoogle ScholarPubMed
Wimber, D. E. (1960). Duration of the nuclear cycle in Tradescantia paludosa root tips as measured with H3 -thymidine. Amer. J. Bot., 47: 828.Google Scholar