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Down's Syndrome and Maternal Inbreeding*

Published online by Cambridge University Press:  01 August 2014

Ei Matsunaga
Ei Matsunaga*
Affiliation:
Dept. of Human Genetics, National Institute of Genetics, Mishima (Nippon)

Summary

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In order to test the possible effect of maternal inbreeding upon non-disjunction, ancestors of 104 children with Down's syndrome born to younger mothers were identified on the basis of official records. Among them, 6 had related parents, while 10 of the fathers and 12 of the mothers had also such parents. The relationship comprises first-cousins, first-cousins once removed, and second cousins. It was concluded that recessive genes are unlikely to be involved in the aetiology of non-disjunction of the 21st autosome, at least in younger mothers.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 15 , Issue 3 , July 1966 , pp. 224 - 230
Copyright
Copyright © The International Society for Twin Studies 1966

Footnotes

*

This paper is dedicated to Professor Dr. O. Frhr. von Verschuer in honour of his seventieth birthday. Contribution no. 618 from the National Institute of Genetics, Japan.

References

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