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Does the Respiratory Distress Syndrome in Twins and Singletons Run Different Risks of Persistent Ductus Arteriosus?

Published online by Cambridge University Press:  01 August 2014

V. Zanardo ,
P. Foti ,
D. Trevisanuto ,
P. Zambon ,
G. Stellin  and
O. Milanesi
V. Zanardo*
Affiliation:
Department of Pediatrics, University of Padua, Italy
P. Foti
Affiliation:
Department of Pediatrics, University of Padua, Italy
D. Trevisanuto
Affiliation:
Department of Pediatrics, University of Padua, Italy
P. Zambon
Affiliation:
Department of Pediatrics, University of Padua, Italy
G. Stellin
Affiliation:
Institute of Cardiovascular Surgery, University of Padua, Italy
O. Milanesi
Affiliation:
Department of Pediatrics, University of Padua, Italy
*
Dipartimento di Pediatria, Università di Padova, Via Giustiniani 3, 35128 Padova, Italy

Abstract

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The incidence and evolution of patent ductus arteriosus (PDA) was evaluated in twins and preterm singletons with birth weight ≤ 1750 g admitted to our Department in 1987 for respiratory distress syndrome (RDS). Screening by echocardiography and Doppler-flow studies (AT MK 600) was performed on the third day of life. Out of 91 neonates who needed intubation and ventilation during this 12-month period (23.8% of admissions), 40 weighed less than 1750 g and of these 40, 14 were twins (35%). Hemodynamically significant PDA was documented in 13 patients; of these, only 5 were preterm singletons and 8 were twins. Two twins weighing < 1000 g received no therapy for ductus closure; one ductus closed spontaneously, the other had an early demise. Three twins and 2 preterm singletons received indomethacin; one of the twins needed a second cycle for definitive ductus closure. Three twins and three preterm singletons underwent surgery, while one twin died on the 10th postoperative day. Screening and early therapy of PDA during RDS could be of great clinical importance. Twinning seems to play a role in the incidence and evolution of PDA and this needs to be evaluated in further studies.

Keywords

Respiratory distress syndromePatent ductus arteriosusPremature twins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 38 , Issue 3-4 , October 1989 , pp. 315 - 318
Copyright
Copyright © The International Society for Twin Studies 1989

References

REFERENCES

1. Bleker, OP, Brever, W, Huidekoper, BL (1979): A study of birth weight placental weight and mortality of twins as to singletons. Brit J Obstet Gynaecol 86:111–118.CrossRefGoogle ScholarPubMed
2. Burn, J, Corney, G (1984): Congenital heart defects and twinning. Acta Genet Med Gemellol 33:61–69.Google ScholarPubMed
3. Dudell, GG, Gersony, WM (1984): Patent ductus arteriosus in neonates with severe respiratory disease. J Pediatr 104:915–918.CrossRefGoogle ScholarPubMed
4. Ellison, RC, Peckham, GJ, Lang, P, Talner, NS, Lerer, TJ, Lin, L, Dooley, KJ, Nadas, AS (1983): Evaluation of the preterm infant for patent ductus arterious. J Pediatr 71:3–6.CrossRefGoogle Scholar
5. Gersony, WM, Peckham, GJ, Ellison, RC, Miettinen, OS, Nadas, AS (1983): Effects of indomethacin in infants with patent ductus arteriosus. Results of a national collaborative study. J Pediatr 102:895–906.CrossRefGoogle ScholarPubMed
6. Källen, B (1986): Congenital malformations in twins: A population study. Acta Genet Med Gemellol 35:167–178.Google ScholarPubMed
7. Medearis, AJ, Jonas, HS, Stockbauer, JW, Domke, HR (1979): Perinatal deaths in twin pregnancy. A five year analysis of statewide statistics in Missouri. Am J Obstet Gynecol 15:413–421.CrossRefGoogle Scholar
8. Ment, LR, Duncan, CC, Ehrenkranz, AR (1985): Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants. J Pediatr 107:937–943.CrossRefGoogle ScholarPubMed
9. Nylander, PPS (1979): Perinatal mortality in twins. Acta Genet Med Gemellol 28:363–368.Google ScholarPubMed
10. Pavone, L, Laurence, KM, Mattina, T, Nuciforo, G, Mollica, F (1986): Twins with acardia and anencephaly. Acta Genet Med Gemellol 34:89–93.Google Scholar
11. Persson, PH, Grennert, L, Gennser, G, Kullander, S (1979): On improved outcome of twin pregnancies. Acta Obtset Gynecol Scand 58:3–7.CrossRefGoogle ScholarPubMed