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Published online by Cambridge University Press: 01 August 2014
Antimitotic drugs essentially induce a direct inhibition on the malignant cellular proliferation. Secondary mechanisms should even be considered: i.e. neoplastic clonal disadvantage, indirect antivitaminic mechanism for the intestinal atrophy caused by antimitotic drugs, endocrine failance due to the antimitotic drugs damages in the endocrine glands (pharmacological « hypophysectomy » and « castraction ») etc.