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Clinical Studies on the Effect of Imuran and Vincristine in the Treatment of Leukaemia

Published online by Cambridge University Press:  01 August 2014

E. Storti ,
A. Traldi  and
D. Quaglino
E. Storti
Affiliation:
Istituto di Patologia Medica dell'Università, Modena
A. Traldi
Affiliation:
Istituto di Patologia Medica dell'Università, Modena
D. Quaglino
Affiliation:
Istituto di Patologia Medica dell'Università, Modena

Summary

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The Authors describe the therapeutic effects obtained with Vincristine and Imuran in patients with acute leukaemia.

The results obtained with Vincristine indicate that the drug may be usefully employed in some cases of lymphoblastic leukaemia, both in the untreated phase or when the disease has become resistant to other antimetabolites. The remissions are of shorter duration compared with those obtained with other available compounds and are substantially confined to the lymphoblastic variety of acute leukaemia.

The preliminary clinical trial with Imuran has shown that the drug is better tolerated than 6-mercaptopurine and is able to produce good and satisfactory remissions in lymphoblastic and myeloblastic leukaemia, as well as in the blastic crisis of chronic granulocytic leukaemia, provided the dosage employed reaches 7-8 mg/Kg body weight daily.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 1 , January 1968 , pp. 220 - 231
Copyright
Copyright © The International Society for Twin Studies 1968

References

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